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  • 1 Juárez University of Durango State, Avenida Universidad S/N, 34000 Durango, Dgo, Mexico
  • | 2 Juárez University of Durango State, Avenida Universidad S/N, 34000 Durango, Durango, Mexico
  • | 3 Juárez University of Durango State, Cuauhtémoc 223 norte, 34000 Durango, Mexico
  • | 4 Servicios de Salud de Durango, Durango, Mexico, Talpa S/N, 34170 Durango, Mexico
  • | 5 General Hospital, Secretary of Health, Avenida 5 de febrero 220, 34000 Durango, Mexico
  • | 6 Charité Medical School, Hindenburgdamm 27, D-12203 Berlin, Germany
Open access

Some symptoms of menopause have also been described in patients with toxoplasmosis. Whether Toxoplasma gondii (T. gondii) infection has any influence on clinical manifestations of menopause is yet unknown. We sought to determine whether T. gondii exposure is associated with symptoms and signs of menopause. We performed a cross-sectional study of women attending a public health center in Durango City, Mexico. Participants were examined for the presence of anti-Toxoplasma IgG and IgM antibodies using enzyme-linked immunoassays. A questionnaire including 47 symptoms and signs potentially associated with menopause was applied. Association of seroprevalence for T. gondii with clinical characteristics of women was assessed by bivariate and multivariate analyses. Bivariate analysis showed that bouts of rapid heartbeat, breast pain, electric shock sensation, dizziness, digestive problems, low back pain, and migraine were associated with seropositivity to either IgG anti-T. gondii alone or both IgG and IgM anti-T. gondii. Breast pain was the only variable that was found to be associated with IgG seropositivity to T. gondii by multivariate analysis: (OR = 2.84; 95% CI: 1.35–5.90; P = 0.005). Our results suggest that T. gondii exposure may influence on the clinical manifestations of menopause. Results deserve further research.

  • 1.

    Tenter AM , Heckeroth AR, Weiss LM: Toxoplasma gondii: from animals to humans. Int J Parasitol 30, 12171258 (2000)

  • 2.

    Montoya JG , Liesenfeld O: Toxoplasmosis. Lancet 363, 19651976 (2004)

  • 3.

    Jones JL , Parise ME, Fiore AE: Neglected parasitic infections in the United States: toxoplasmosis. Am J Trop Med Hyg 90, 794799 (2014)

    • Search Google Scholar
    • Export Citation
  • 4.

    Maenz M , Schlüter D, Liesenfeld O, Schares G, Gross U, Pleyer U: Ocular toxoplasmosis past, present and new aspects of an old disease. Prog Retin Eye Res 39, 77106 (2014)

    • Search Google Scholar
    • Export Citation
  • 5.

    Machala L , Kodym P, Malý M, Geleneky M, Beran O, Jilich D: Toxoplasmosis in immunocompromised patients. Epidemiol Mikrobiol Imunol 64, 5965 (2015)

    • Search Google Scholar
    • Export Citation
  • 6.

    Duffy AR , Beckie TM, Brenner LA, Beckstead JW, Seyfang A, Postolache TT, Groer MW: Relationship between Toxoplasma gondii and mood disturbance in women veterans. Mil Med 180, 621625 (2015)

    • Search Google Scholar
    • Export Citation
  • 7.

    Groër MW , Yolken RH, Xiao JC, Beckstead JW, Fuchs D, Mohapatra SS, Seyfang A, Postolache TT: Prenatal depression and anxiety in Toxoplasma gondii-positive women. Am J Obstet Gynecol 204, e17 (2011)

    • Search Google Scholar
    • Export Citation
  • 8.

    Sutterland AL , Fond G, Kuin A, Koeter MW, Lutter R, van G ool T, Yolken R, Szoke A, Leboyer M, de Haan L: Beyond the association. Toxoplasma gondii in schizophrenia, bipolar disorder, and addiction: systematic review and metaanalysis. Acta Psychiatr Scand 132, 161179 (2015)

    • Search Google Scholar
    • Export Citation
  • 9.

    Alvarado-Esquivel C , Urbina-Álvarez JD, Estrada-Martínez S, Torres-Castorena A, Molotla-de-León G, Liesenfeld O, Dubey JP: Toxoplasma gondii infection and schizophrenia: a case control study in a low Toxoplasma seroprevalence Mexican population. Parasitol Int 60, 151155 (2011)

    • Search Google Scholar
    • Export Citation
  • 10.

    Gajewski PD , Falkenstein M, Hengstler JG, Golka K: Toxoplasma gondii impairs memory in infected seniors. Brain Behav Immun 36, 193199 (2014)

    • Search Google Scholar
    • Export Citation
  • 11.

    Alvarado-Esquivel C , Liesenfeld O, Márquez-Conde JA, Estrada-Martínez S, Dubey JP: Seroepidemiology of infection with Toxoplasma gondii in workers occupationally exposed to water, sewage, and soil in Durango, Mexico. J Parasitol 96, 847850 (2010)

    • Search Google Scholar
    • Export Citation
  • 12.

    Koseoglu E , Yazar S, Koc I: Is Toxoplasma gondii a causal agent in migraine? Am J Med Sci 338, 120122 (2009)

  • 13.

    Brinton RD , Yao J, Yin F, Mack WJ, Cadenas E: Perimenopause as a neurological transition state. Nat Rev Endocrinol 11, 393405 (2015)

  • 14.

    Ibrahimi K , Couturier EG, MaassenVanDenBrink A: Migraine and perimenopause. Maturitas 78, 277280 (2014)

  • 15.

    MacGregor EA : Perimenopausal migraine in women with vasomotor symptoms. Maturitas 71, 7982 (2012)

  • 16.

    Borrow AP , Cameron NM: Estrogenic mediation of serotonergic and neurotrophic systems: implications for female mood disorders. Prog Neuropsychopharmacol Biol Psychiatry 54, 1325 (2014)

    • Search Google Scholar
    • Export Citation
  • 17.

    Weber MT , Maki PM, McDermott MP: Cognition and mood in perimenopause: a systematic review and metaanalysis. J Steroid Biochem Mol Biol 142, 9098 (2014)

    • Search Google Scholar
    • Export Citation
  • 18.

    Seritan AL , Iosif AM, Park JH, DeatherageHand D, Sweet RL, Gold EB: Self-reported anxiety, depressive, and vasomotor symptoms: a study of perimenopausal women presenting to a specialized midlife assessment center. Menopause 17, 410415 (2010)

    • Search Google Scholar
    • Export Citation
  • 19.

    Rasgon N , Shelton S, Halbreich U: Perimenopausal mental disorders: epidemiology and phenomenology. CNS Spectr 10, 471478 (2005)

  • 20.

    Alvarado-Esquivel C , Estrada-Martínez S, Pizarro-Villalobos H, Arce-Quiñones M, Liesenfeld O, Dubey JP: Seroepidemiology of Toxoplasma gondii infection in general population in a northern Mexican city. J Parasitol 97, 4043 (2011)

    • Search Google Scholar
    • Export Citation
  • 21.

    Harker KS , Ueno N, Lodoen MB: Toxoplasma gondii dissemination: a parasite’s journey through the infected host. Parasite Immunol 37, 141149 (2015)

    • Search Google Scholar
    • Export Citation
  • 22.

    Kirchhoff LV , Weiss LM, Wittner M, Tanowitz HB: Parasitic diseases of the heart. Front Biosci 9, 706723 (2004)

  • 23.

    Olawaiye A , Withiam-Leitch M, Danakas G, Kahn K: Mastalgia: a review of management. J Reprod Med 50, 933939 (2005)

  • 24.

    Gumm R , Cunnick GH, Mokbel K: Evidence for the management of mastalgia. Curr Med Res Opin 20, 681684 (2004)

  • 25.

    Smith RL , Pruthi S, Fitzpatrick LA: Evaluation and management of breast pain. Mayo Clin Proc 79, 353372 (2004)

  • 26.

    Marchettini P , Lacerenza M, Mauri E, Marangoni C: Painful peripheral neuropathies. Curr Neuropharmacol 4, 175181 (2006)

  • 27.

    Alvarado-Esquivel C , Campillo-Ruiz F, Liesenfeld O: Seroepidemiology of infection with Toxoplasma gondii in migrant agricultural workers living in poverty in Durango, Mexico. Parasit Vectors 6, 113 (2013)

    • Search Google Scholar
    • Export Citation
  • 28.

    Alvarado-Esquivel C , Pacheco-Vega SJ, Hernández-Tinoco J, Sánchez-Anguiano LF, Berumen-Segovia LO, Rodríguez-Acevedo FJ, Beristain-García I, Rábago-Sánchez E, Liesenfeld O, Campillo-Ruiz F, Güereca-García OA: Seroprevalence of Toxoplasma gondii infection and associated risk factors in Huicholes in Mexico. Parasit Vectors 7, 301 (2014)

    • Search Google Scholar
    • Export Citation
  • 29.

    Yang M , Perez E: Disseminated toxoplasmosis as a cause of diarrhea. South Med J 88, 860861 (1995)

  • 30.

    Ganji M , Tan A, Maitar MI, Weldon-Linne CM, Weisenberg E, Rhone DP: Gastric toxoplasmosis in a patient with acquired immunodeficiency syndrome. A case report and review of the literature. Arch Pathol Lab Med 127, 732734 (2003)

    • Search Google Scholar
    • Export Citation
  • 31.

    Wanderley FS , Porto WJ, Câmara DR, da C ruz NL, Feitosa BC, Freire RL, de Moraes EP, Mota RA: Experimental vaginal infection of goats with semen contaminated with the “CPG” strain of Toxoplasma gondii. J Parasitol 99, 610613 (2013)

    • Search Google Scholar
    • Export Citation
  • 32.

    Bobic B , Klun I, Nikolic A, Vujanic M, Zivkovic T, Ivovic V, Djurkovic-Djakovic O: Seasonal variations in human Toxoplasma infection in Serbia. Vector Borne Zoonotic Dis 10, 465469 (2010)

    • Search Google Scholar
    • Export Citation
  • 33.

    Gong Z , Luo L, Xiao H: Preliminary study on ToRCH epidemic laws in Wuhan region. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 13, 139141 (1999)

    • Search Google Scholar
    • Export Citation
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Senior editors

Editor(s)-in-Chief: Dunay, Ildiko Rita

Editor(s)-in-Chief: Heimesaat, Markus M.

Vice Editor(s)-in-Chief: Fuchs, Anja

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Chair of the Editorial Board:
Jeffrey S. Buguliskis (Thomas Jefferson University, USA)

  • Jörn Albring (University of Münster, Germany)
  • Stefan Bereswill (Charité - University Medicine Berlin, Germany)
  • Dunja Bruder (University of Megdeburg, Germany)
  • Jan Buer (University of Duisburg, Germany)
  • Jeff Buguliskis (Thomas Jefferson University, USA)
  • Edit Buzas (Semmelweis University, Hungary)
  • Charles Collyer (University of Sydney, Australia)
  • Renato Damatta (UENF, Brazil)
  • Ivelina Damjanova (Semmelweis University, Hungary)
  • Maria Deli (Biological Research Center, HAS, Hungary)
  • Olgica Djurković-Djaković (University of Belgrade, Serbia)
  • Jean-Dennis Docquier (University of Siena, Italy)
  • Anna Erdei (Eötvös Loránd University, Hungary)
  • Zsuzsanna Fabry (University of Washington, USA)
  • Beniam Ghebremedhin (Witten/Herdecke University, Germany)
  • Nancy Guillen (Institute Pasteur, France)
  • Georgina L. Hold (University of Aberdeen, United Kingdom)
  • Ralf Ignatius (Charité - University Medicine Berlin, Germany)
  • Zsuzsanna Izsvak (MDC-Berlin, Germany)
  • Achim Kaasch (University of Cologne, Germany)
  • Tamás Laskay (University of Lübeck, Germany)
  • Oliver Liesenfeld (Roche, USA)
  • Shreemanta Parida (Vaccine Grand Challenge Program, India)
  • Matyas Sandor (University of Wisconsin, USA)
  • Ulrich Steinhoff (University of Marburg, Germany)
  • Michal Toborek (University of Miami, USA)
  • Mary Jo Wick (University of Gothenburg, Sweden)
  • Susanne A. Wolf (MDC-Berlin, Germany)

 

Dr. Dunay, Ildiko Rita
Magdeburg, Germany
E-mail: ildikodunay@gmail.com

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