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  • 1 Juárez University of Durango State, Avenida Universidad S/N, 34000 Durango, Dgo, Mexico
  • 2 Juárez University of Durango State, Avenida Universidad S/N, 34000 Durango, Durango, Mexico
  • 3 Juárez University of Durango State, Cuauhtémoc 223 norte, 34000 Durango, Mexico
  • 4 Servicios de Salud de Durango, Durango, Mexico
  • 5 Secretary of Health, Avenida 5 de febrero 220, 34000 Durango, Mexico
  • 6 Charité Medical School, Hindenburgdamm 27, D-12203 Berlin,, Germany
  • ** Roche Molecular Systems, Pleasanton, CA 94588, USA
Open access

We assessed the association of Toxoplasma gondii infection and depression in a sample of psychiatric patients and control subjects without depression. We performed an age- and gender-matched case—control study of 89 patients suffering from depression attended in a public psychiatric hospital in Durango City, Mexico and 356 control subjects without depression from the general population of the same city. Participants were tested for the presence of anti-Toxoplasma IgG and IgM antibodies using enzymelinked immunoassays. Anti-T. gondii IgG antibodies were found in 11 (12.4%) of the 89 cases and in 22 (6.2%) of the 356 controls (OR = 2.14; 95% CI: 1.00–4.59; P = 0.04). Anti-T. gondii IgM antibodies were found in four (19%) of 21 anti-T. gondii IgG seropositive controls but not in 11 anti-T. gondii IgG seropositive cases (P = 0.27). Patients aged 30 years old and younger had a significantly higher seroprevalence of T. gondii infection than controls of the same age group (P = 0.001). Results of the present study suggest a potential association between T. gondii infection and depression. Furthers studies to confirm our results and to determine the epidemiology of T. gondii in young depressed patients should be conducted.

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