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Cosme Alvarado-Esquivel Juárez University of Durango State, Avenida Universidad S/N, 34000 Durango, Dgo, Mexico

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Luis Francisco Sánchez-Anguiano Juárez University of Durango State, Avenida Universidad S/N, 34000 Durango, Durango, Mexico

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Jesús Hernández-Tinoco Juárez University of Durango State, Avenida Universidad S/N, 34000 Durango, Durango, Mexico

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Alma Rosa Pérez-Álamos Juárez University of Durango State, Avenida Universidad S/N, 34000 Durango, Durango, Mexico

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Yazmin del Rosario Rico-Almochantaf Juárez University of Durango State, Avenida Universidad S/N, 34000 Durango, Dgo, Mexico

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Sergio Estrada-Martínez Juárez University of Durango State, Avenida Universidad S/N, 34000 Durango, Durango, Mexico

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Raquel Vaquera-Enriquez Health Center No. 2 “Dr. Carlos Santamaría”, Servicios de Salud de Durango, Durango, Mexico, Talpa S/N, 34170 Durango, Mexico

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Arturo Díaz-Herrera Health Center No. 2 “Dr. Carlos Santamaría”, Servicios de Salud de Durango, Durango, Mexico, Talpa S/N, 34170 Durango, Mexico

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Agar Ramos-Nevarez Clínica de Medicina Familiar, Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, Predio Canoas S/N, 34079 Durango, Mexico

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Ada Agustina Sandoval-Carrillo Juárez University of Durango State, Avenida Universidad S/N, 34000 Durango, Durango, Mexico

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José Manuel Salas-Pacheco Juárez University of Durango State, Avenida Universidad S/N, 34000 Durango, Durango, Mexico

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Sandra Margarita Cerrillo-Soto Clínica de Medicina Familiar, Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, Predio Canoas S/N, 34079 Durango, Mexico

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Elizabeth Irasema Antuna-Salcido Juárez University of Durango State, Avenida Universidad S/N, 34000 Durango, Durango, Mexico

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Oliver Liesenfeld Charité Medical School, Hindenburgdamm 27, D-12203 Berlin, Germany

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Carlos Alberto Guido-Arreola Clínica de Medicina Familiar, Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, Predio Canoas S/N, 34079 Durango, Mexico

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Infection with Toxoplasma gondii in brain may cause some symptoms that resemble those in women with premenstrual syndrome. To determine the association of T. gondii infection with symptoms and signs of premenstrual syndrome, we examined 489 women aged 30–40 years old. Sera of participants were analyzed for the presence of anti-Toxoplasma IgG and IgM antibodies using enzyme-linked immunoassays (EIA) and T. gondii DNA by polymerase chain reaction (PCR).

Anti-T. gondii IgG antibodies were found in 38 (7.8%) of the women studied. Anti-T. gondii IgM antibodies were found in 13 (34.2%) of the 38 IgG seropositive women. Logistic regression showed two variables associated with seropositivity to T. gondii: presence of diarrhea (odds ratio [OR] = 6.10; 95% confidence interval [CI]: 1.37–27.85; P = 0.01) and weight gain (OR = 2.89; 95% CI: 1.37–6.07; P = 0.005), and two variables associated with high (>150 IU/ml) levels of IgG against T. gondii: presence of diarrhea (OR = 7.40; 95% CI: 1.79–30.46; P = 0.006) and abdominal inflammation (OR = 3.38; 95% CI: 1.13–10.10; P = 0.02). Positivity to EIA IgG and PCR was positively associated with obesity and negatively associated with joint pain by bivariate analysis.

Our study for the first time reveals a potential association of T. gondii infection with clinical manifestations of premenstrual syndrome.

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Senior editors

Editor(s)-in-Chief: Dunay, Ildiko Rita, Prof. Dr. Pharm, Dr. rer. nat., University of Magdeburg, Germany

Editor(s)-in-Chief: Heimesaat, Markus M., Prof. Dr. med., Charité - University Medicine Berlin, Germany

Editorial Board

  • Berit Bangoura, Dr. DVM. PhD,  University of Wyoming, USA
  • Stefan Bereswill, Prof. Dr. rer. nat., Charité - University Medicine Berlin, Germany
  • Dunja Bruder, Prof. Dr. rer. nat., University of Magdeburg, Germany
  • Jan Buer, Prof. Dr. med., University of Duisburg, Germany
  • Edit Buzas, Prof. Dr. med., Semmelweis University, Hungary
  • Renato Damatta, Prof. PhD, UENF, Brazil
  • Maria Deli, MD, PhD, DSc, Biological Research Center, HAS, Hungary
  • Olgica Djurković-Djaković, Prof. Phd, University of Belgrade, Serbia
  • Jean-Dennis Docquier, Prof. Dr. med., University of Siena, Italy
  • Zsuzsanna Fabry, Prof. Phd, University of Washington, USA
  • Ralf Ignatius, Prof. Dr. med., Charité - University Medicine Berlin, Germany
  • Achim Kaasch, Prof. Dr. med., Otto von Guericke University Magdeburg, Germany
  • Oliver Liesenfeld, Prof. Dr. med., Inflammatix, USA
  • Matyas Sandor, Prof. PhD, University of Wisconsin, USA
  • Ulrich Steinhoff, Prof. PhD, University of Marburg, Germany
  • Michal Toborek, Prof. PhD, University of Miami, USA
  • Susanne A. Wolf, PhD, MDC-Berlin, Germany

 

Dr. Dunay, Ildiko Rita
Magdeburg, Germany
E-mail: ildiko.dunay@med.ovgu.de

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European Journal of Microbiology and Immunology
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