Authors:
Thomas Mclaughlin Center for Psychiatric Medicine, North Andover, Massachusetts, USA

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Marlene Oscar-Berman Department of Psychiatry, Anatomy & Neurobiology, Boston VA and Boston University School of Medicine, Boston, Massachusetts, USA

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Thomas Simpatico Department of Psychiatry, Global Integrated Services Unit of Vermont Center for Clinical & Translational Science, University of Vermont College of Medicine, Burlington, Vermont, USA

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John Giordano Department of Holistic Medicine, G & G Health Care Services LLC, North Miami Beach, Florida, USA

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Scot Jones Department of Holistic Medicine, G & G Health Care Services LLC, North Miami Beach, Florida, USA

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Debmayla Barh Center for Genomics and Applied Gene Technology, Institute of Integrative Omics and Applied Biotechnology (IIOAB), Nonakuri, Purba Medinipur, West Bengal, India

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William B. Downs Department of Nutrigenomics, LifeGen, Inc., Austin, Texas, USA

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Roger L. Waite Department of Nutrigenomics, LifeGen, Inc., Austin, Texas, USA

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Margaret Madigan Department of Nutrigenomics, LifeGen, Inc., Austin, Texas, USA

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Kristina Dushaj Department of Clinical Neurology, PATH Foundation NY, New York, New York, USA

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Raquel Lohmann Department of Clinical Neurology, PATH Foundation NY, New York, New York, USA

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Eric R. Braverman Department of Clinical Neurology, PATH Foundation NY, New York, New York, USA

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David Han Department of Management Science and Statistics, the University of Texas at San Antonio, San Antonio, Texas, USA

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Kenneth Blum Department of Psychiatry, Global Integrated Services Unit of Vermont Center for Clinical & Translational Science, University of Vermont College of Medicine, Burlington, Vermont, USA
Department of Holistic Medicine, G & G Health Care Services LLC, North Miami Beach, Florida, USA
Center for Genomics and Applied Gene Technology, Institute of Integrative Omics and Applied Biotechnology (IIOAB), Nonakuri, Purba Medinipur, West Bengal, India
Department of Nutrigenomics, LifeGen, Inc., Austin, Texas, USA
Department of Psychiatry and McKnight Brain Institute, University of Florida, College of Medicine, Gainesville, Florida, USA
Department of Clinical Neurology, PATH Foundation NY, New York, New York, USA
Dominion Diagnostics, LLC, North Kingstown, Rhode Island, USA
Department of Addiction Research & Therapy, Malibu Beach Recovery Center, Malibu Beach, California, USA
Department of Psychiatry, College of Medicine, University of Florida, and McKnight Brain Institute, Gainesville, Florida, USA

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Abstract

Background and aims

Many patients presenting multiple behaviors including drug and food abuse as well as other pathological repetitive unwanted activities such as gambling, self-mutilation and paraphilias may not be appropriately diagnosed. Here we present a case of a male presenting many of these seemingly diverse behaviors and finally diagnosed with reward deficiency syndrome (RDS) by his attending physician.

Methods

The use of the dopamine agonist, ropinirole after two weeks showed improvement in terms of sexual behavior but tolerance set in and was discontinued especially when an infraction occurred with the patient's insurance. In this article, we carefully explore the potential of ropinirole to downregulate dopamine receptors causing adenylate cyclase receptor supersensitivity and tolerance a feature of neurotransmitter cross-talk. Based on previous scientific evidence showing KB220Znutrigenomic amino-acid therapy (NAAT) to rapidly (post one-hour) activate dopaminergic pathways in both the pre-frontal cortex cingulate gyrus (relapse loci) and ventral tegmental area-caudate-accumbens-putamen (craving and emotion loci) the patient was prescribed NAAT.

Results and discussion

Within one week of utilization the repetitive paraphilia was eliminated. There were also a number of other positive effects such as enhanced focus that persisted even after the patient stopped using KB220Z suggesting neuroplasticity (e.g. altruistic thoughts). However, these observed profound benefits require more in-depth study, especially in a large cohort against a placebo. While this report focused on a rapid response rather than long-term benefits previously associated with NAAT, it is somewhat encouraging and longer term required follow-up and larger placebo controlled studies are warranted before any definitive conclusions could be gleaned from this case report.

  • G. Aloisi E. Silvano M. Rossi M. J. Millan R. Maggio 2011 Differential induction of adenylyl cyclase supersensitivity by antiparkinson drugs acting as agonists at dopamine D1/D2/D3 receptors vs D2/D3receptors only: Parallel observations from co-transfected human and native cerebral receptors Neuropharmacology 60 439 445.

    • Search Google Scholar
    • Export Citation
  • American Psychiatric Association 2000 Diagnostic and statistical manual of mental disorders-IV (text revision) American Psychiatric Publishing, Inc Arlington, VA.

    • Search Google Scholar
    • Export Citation
  • U. Banerjee 1974 Modification of the isolation-induced abnormal behavior in male Wistar rats by destructive manipulation of the central monoaminergic systems Behavioral Biology 11 573 577.

    • Search Google Scholar
    • Export Citation
  • D. Bhugra D. Popelyuk I. McMullen 2010 Paraphilias across cultures: Contexts and controversies Journal of Sex Research 47 242 256.

  • K. Blum A. L. Chen T. J. Chen E. R. Braverman J. Reinking S. H. Blum K. Cassel B. W. Downs R. L. Waite L. Williams T. J. Prihoda M. M. Kerner T. Palomo D. E. Comings H. Tung P. Rhoades M. Oscar-Berman 2008 Activation instead of blocking mesolimbic dopaminergic reward circuitry is a preferred modality in the long term treatment of reward deficiency syndrome (RDS):Acommentary Theoretical Biology and Medical Modelling 12 24.

    • Search Google Scholar
    • Export Citation
  • K. Blum T. J. Chen B. W. Downs A. Bowirrat R. L. Waite E. R. Braverman M. Madigan M. Oscar-Berman N. DiNubile E. Stice J. Giordano S. Morse M. Gold 2009 Neurogenetics of dopaminergic receptor supersensitivity in activation of brain reward circuitry and relapse: Proposing “deprivation-amplification relapse therapy” (DART) Postgraduate Medicine 121 6 176 196.

    • Search Google Scholar
    • Export Citation
  • K. Blum T. J. Chen S. Morse J. Giordano A. L. Chen J. Thompson C. Allen A. Smolen J. Lubar E. Stice B. W. Downs R. L. Waite M. A. Madigan M. Kerner F. Fornari E. R. Braverman 2010 Overcoming qEEG abnormalities and reward gene deficits during protracted abstinence in male psychostimulant and polydrug abusers utilizing putative dopamine D2 agonist therapy: Part 2 Postgraduate Medicine 122 214 226.

    • Search Google Scholar
    • Export Citation
  • K. Blum E. Gardner M. Oscar-Berman M. Gold 2012 “Liking” and “wanting” linked to reward deficiency syndrome (RDS): Hypothesizing differential responsivity in brain reward circuitry Current Pharmaceutical Design 18 113 118.

    • Search Google Scholar
    • Export Citation
  • K. Blum J. Giordano M. Oscar-Berman A. Bowirrat T. Simpatico D. Barh 2012 Diagnosis and healing in veterans suspected of suffering from post-traumatic stress disorder (PTSD) using reward gene testing and reward circuitry natural dopaminergic activation Journal of Genetic Syndrome and Gene Therapy 3 1000116.

    • Search Google Scholar
    • Export Citation
  • K. Blum M. S. Gold 2011 Neuro-chemical activation of brain reward meso-limbic circuitry is associated with relapse prevention and drug hunger: A hypothesis Medical Hypotheses 76 576 584.

    • Search Google Scholar
    • Export Citation
  • K. Blum Y. Liu R. Shriner M. S. Gold 2011 Reward circuitry dopaminergic activation regulates food and drug craving behavior Current Pharmaceutical Design 17 1158 1167.

    • Search Google Scholar
    • Export Citation
  • K. Blum M. Oscar-Berman J. Giordano B. Downs T. Simpatico D. Han J. Femino 2012 Neurogenetic impairments of brain reward circuitry links to reward deficiency syndrome (RDS): Potential nutrigenomic induced dopaminergic activation Journal of Genetic Syndrome and Gene Therapy 17 4.

    • Search Google Scholar
    • Export Citation
  • K. Blum P. J. Sheridan R. C. Wood E. R. Braverman T. J. Chen J. G. Cull D. E. Comings 1996 The D2 dopamine re-ceptor gene as a determinant of reward deficiency syndrome Journal of the Royal Society of Medicine 89 396 400.

    • Search Google Scholar
    • Export Citation
  • K. Blum E. Stice Y. Liu J. Giordano S. Morse B. W. Downs R. L. Waite M. Madigan E. R. Braverman M. Kerner M. Oscar-Berman D. Miller S. Stokes C. Gant T. Thompson C. Allen A. Smilen A. Bowirrat M. Gold 2011 “Dopamine Resistance” in brain reward circuitry as a function of DRD2 gene receptor polymorphisms in RDS: Synaptamine complex variant (KB220) induced “Dopamine Sensitivity” and enhancement of happiness XIX World Congress of Psychiatric Genetics Washington, D.C..

    • Search Google Scholar
    • Export Citation
  • K. Blum T. Werner S. Carnes P. Carnes A. Bowirrat J. Giordano M. Oscar-Berman M. Gold 2012 Sex, drugs, and rock ‘n’ roll: Hypothesizing common mesolimbic activation as a function of reward gene polymorphisms Journal of Psychoactive Drugs 44 38 55.

    • Search Google Scholar
    • Export Citation
  • B. Chen H. Liu J. Ren A. Guo 2012 Mutation of drosophila dopamine receptor DopR leads to male-male courtship behavior Biochemical and Biophysical Research Communications 423 557 563.

    • Search Google Scholar
    • Export Citation
  • T. J. H. Chen K. Blum L. C. H. Chen A. Bowirrat B. W. Downs M. A. Madigan R. L. Waite J. A. Bailey M. Kerner S. Yelandi J. Giordano S. Morse D. Miller E. R. Braverman 2011 Neurogenetics and clinical evidence for the putative activation of the brain reward circuitry by amino-acid precursor-catabolic enzyme inhibition therapeutic agent (a neuroadaptogen): Proposing an addiction candidate gene panel map Journal of Psychoactive Drugs 43 108 127.

    • Search Google Scholar
    • Export Citation
  • D. E. Comings 1994 Role of genetic factors in human sexual behavior based on studies of Tourette syndrome and ADHD probands and their relatives American Journal of Medical Genetics 54 227 241.

    • Search Google Scholar
    • Export Citation
  • D. E. Comings K. Blum 2000 Reward deficiency syndrome: Genetic aspects of behavioral disorders Progress in Brain Research 126 325 341.

  • Cross-Disorder Group of the Psychiatric Genomics Consortium J. W. Smoller N. Craddock K. Kendler P. H. Lee B. M. Neale J. I. Nurnberger S. Ripke S. Santangelo P. F. Sullivan 2013 Identification of risk loci with shared effects on five major psychiatric disorders: A genome-wide analysis The Lancet 381 1371 1379.

    • Search Google Scholar
    • Export Citation
  • J. Daw G. Guo 2011 The influence of three genes on whether adolescents use contraception, USA 1994–2002 Population Studies (Camb) 65 253 271.

    • Search Google Scholar
    • Export Citation
  • G. Derosa P. Maffioli 2012 Anti-obesity drugs: A review about their effects and their safety Expert Opinion on Drug Safety 11 459 471.

  • R. J. Eden B. Costall A. M. Domeney P. A. Gerrard C. A. Harvey M. E. Kelly R. J. Naylor D. A. A. Owen A. Wright 1991 “Preclinical pharmacology of ropinirole (SK&F 101468-A) a novel dopamine D2 agonist” Pharmacology Biochemistry and Behavior 38 147 154.

    • Search Google Scholar
    • Export Citation
  • E. L. Gardner 2011 Addiction and brain reward and antireward pathways Advances in Psychosomatic Medicine 30 22 60.

  • G. Guo Y. Tong 2006 Age at first sexual intercourse, genes, and social context: Evidence from twins and the dopamine D4 receptor gene Demography 43 747 769.

    • Search Google Scholar
    • Export Citation
  • W. H. James 1995 Sexual expression, genetics, and testosterone in Tourette syndrome American Journal of Medical Genetics 60 593.

  • J. Kerbeshian L. Burd 1991 Tourette syndrome and recurrent paraphilic masturbatory fantasy Canadian Journal of Psychiatry 36 155 157.

  • M. F. Li B. M. Cheung 2011 Rise and fall of anti-obesity drugs World Journal of Diabetes 2 19 23.

  • H. Mack M. A. Fullana A. J. Russell D. Mataix-Cols E. Nakatani I. Heyman 2010 Obsessions and compulsions in children with Asperger's syndrome or high-functioning autism: A case-control study The Australian and New Zealand Journal of Psychiatry 44 1082 1088.

    • Search Google Scholar
    • Export Citation
  • D. K. Miller A. Bowirrat M. Manka M. Miller S. Stokes D. Manka C. Allen C. Gant B. W. Downs A. Smolen E. Stevens S. Yeldandi K. Blum 2010 Acute intravenous synaptamine complex variant KB220™ “normalizes” neurological dysregulation in patients during protracted abstinence from alcohol and opiates as observed using quantitative electroencephalographic and genetic analysis for reward polymorphisms: Part 1, pilot study with 2 case reports Postgraduate Medicine 122 188 213.

    • Search Google Scholar
    • Export Citation
  • W. B. Miller D. J. Pasta J. MacMurray C. Chiu H. Wu D. E. Comings 1999 Dopamine receptor genes are associated with age at first sexual intercourse Journal of Biosocial Science 31 43 54.

    • Search Google Scholar
    • Export Citation
  • J. Money 1990 Gay, straight, and in-between: The sexology of erotic orientation Oxford University Press New York.

  • C. Moser P. J. Kleinplatz 2005 DSM-IV-TR and the paraphilias: An argument for removal Journal of Psychology and Human Sexuality 17 91 109.

    • Search Google Scholar
    • Export Citation
  • R. Sandyk 1988 Naltrexone suppresses abnormal sexual behavior in Tourette's syndrome The International Journal of Neuroscience 43 107 110.

    • Search Google Scholar
    • Export Citation
  • R. L. Spitzer 1981 The diagnostic status of homosexuality in DSM-III: A reformulation of the issues The American Journal of Psychiatry 138 210 215.

    • Search Google Scholar
    • Export Citation
  • W. Stekel 1930 Sexual aberrations: The phenomenon of fetishism in relation to sex disorders of the instincts and emotions the parapathiac disorders Liveright Publishing New York.

    • Search Google Scholar
    • Export Citation
  • Z. Wang B. J. Aragona 2004 Neurochemical regulation of pair bonding in male prairie voles Physiology and Behavior 83 319 328.

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Dr. Zsolt Demetrovics
Institute of Psychology, ELTE Eötvös Loránd University
Address: Izabella u. 46. H-1064 Budapest, Hungary
Phone: +36-1-461-2681
E-mail: jba@ppk.elte.hu

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2023  
Web of Science  
Journal Impact Factor 6.6
Rank by Impact Factor Q1 (Psychiatry)
Journal Citation Indicator 1.59
Scopus  
CiteScore 12.3
CiteScore rank Q1 (Clinical Psychology)
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Journal of Behavioral Addictions
Publication Model Gold Open Access
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Article Processing Charge 990 EUR/article for articles submitted after 30 April 2023 (850 EUR for articles submitted prior to this date)
Regional discounts on country of the funding agency World Bank Lower-middle-income economies: 50%
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Subscription Information Gold Open Access

Journal of Behavioral Addictions
Language English
Size A4
Year of
Foundation
2011
Volumes
per Year
1
Issues
per Year
4
Founder Eötvös Loránd Tudományegyetem
Founder's
Address
H-1053 Budapest, Hungary Egyetem tér 1-3.
Publisher Akadémiai Kiadó
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 2062-5871 (Print)
ISSN 2063-5303 (Online)

Senior editors

Editor(s)-in-Chief: Zsolt DEMETROVICS

Assistant Editor(s): Csilla ÁGOSTON

Associate Editors

  • Stephanie ANTONS (Universitat Duisburg-Essen, Germany)
  • Joel BILLIEUX (University of Lausanne, Switzerland)
  • Beáta BŐTHE (University of Montreal, Canada)
  • Matthias BRAND (University of Duisburg-Essen, Germany)
  • Ruth J. van HOLST (Amsterdam UMC, The Netherlands)
  • Daniel KING (Flinders University, Australia)
  • Gyöngyi KÖKÖNYEI (ELTE Eötvös Loránd University, Hungary)
  • Ludwig KRAUS (IFT Institute for Therapy Research, Germany)
  • Marc N. POTENZA (Yale University, USA)
  • Hans-Jurgen RUMPF (University of Lübeck, Germany)

Editorial Board

  • Sophia ACHAB (Faculty of Medicine, University of Geneva, Switzerland)
  • Alex BALDACCHINO (St Andrews University, United Kingdom)
  • Judit BALÁZS (ELTE Eötvös Loránd University, Hungary)
  • Maria BELLRINGER (Auckland University of Technology, Auckland, New Zealand)
  • Henrietta BOWDEN-JONES (Imperial College, United Kingdom)
  • Damien BREVERS (University of Luxembourg, Luxembourg)
  • Wim VAN DEN BRINK (University of Amsterdam, The Netherlands)
  • Julius BURKAUSKAS (Lithuanian University of Health Sciences, Lithuania)
  • Gerhard BÜHRINGER (Technische Universität Dresden, Germany)
  • Silvia CASALE (University of Florence, Florence, Italy)
  • Luke CLARK (University of British Columbia, Vancouver, B.C., Canada)
  • Jeffrey L. DEREVENSKY (McGill University, Canada)
  • Geert DOM (University of Antwerp, Belgium)
  • Nicki DOWLING (Deakin University, Geelong, Australia)
  • Hamed EKHTIARI (University of Minnesota, United States)
  • Jon ELHAI (University of Toledo, Toledo, Ohio, USA)
  • Ana ESTEVEZ (University of Deusto, Spain)
  • Fernando FERNANDEZ-ARANDA (Bellvitge University Hospital, Barcelona, Spain)
  • Naomi FINEBERG (University of Hertfordshire, United Kingdom)
  • Sally GAINSBURY (The University of Sydney, Camperdown, NSW, Australia)
  • Belle GAVRIEL-FRIED (The Bob Shapell School of Social Work, Tel Aviv University, Israel)
  • Biljana GJONESKA (Macedonian Academy of Sciences and Arts, Republic of North Macedonia)
  • Marie GRALL-BRONNEC (University Hospital of Nantes, France)
  • Jon E. GRANT (University of Minnesota, USA)
  • Mark GRIFFITHS (Nottingham Trent University, United Kingdom)
  • Joshua GRUBBS (University of New Mexico, Albuquerque, NM, USA)
  • Anneke GOUDRIAAN (University of Amsterdam, The Netherlands)
  • Susumu HIGUCHI (National Hospital Organization Kurihama Medical and Addiction Center, Japan)
  • David HODGINS (University of Calgary, Canada)
  • Eric HOLLANDER (Albert Einstein College of Medicine, USA)
  • Zsolt HORVÁTH (Eötvös Loránd University, Hungary)
  • Susana JIMÉNEZ-MURCIA (Clinical Psychology Unit, Bellvitge University Hospital, Barcelona, Spain)
  • Yasser KHAZAAL (Geneva University Hospital, Switzerland)
  • Orsolya KIRÁLY (Eötvös Loránd University, Hungary)
  • Chih-Hung KO (Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Taiwan)
  • Shane KRAUS (University of Nevada, Las Vegas, NV, USA)
  • Hae Kook LEE (The Catholic University of Korea, Republic of Korea)
  • Bernadette KUN (Eötvös Loránd University, Hungary)
  • Katerina LUKAVSKA (Charles University, Prague, Czech Republic)
  • Giovanni MARTINOTTI (‘Gabriele d’Annunzio’ University of Chieti-Pescara, Italy)
  • Gemma MESTRE-BACH (Universidad Internacional de la Rioja, La Rioja, Spain)
  • Astrid MÜLLER (Hannover Medical School, Germany)
  • Daniel Thor OLASON (University of Iceland, Iceland)
  • Ståle PALLESEN (University of Bergen, Norway)
  • Afarin RAHIMI-MOVAGHAR (Teheran University of Medical Sciences, Iran)
  • József RÁCZ (Hungarian Academy of Sciences, Hungary)
  • Michael SCHAUB (University of Zurich, Switzerland)
  • Marcantanio M. SPADA (London South Bank University, United Kingdom)
  • Daniel SPRITZER (Study Group on Technological Addictions, Brazil)
  • Dan J. STEIN (University of Cape Town, South Africa)
  • Sherry H. STEWART (Dalhousie University, Canada)
  • Attila SZABÓ (Eötvös Loránd University, Hungary)
  • Hermano TAVARES (Instituto de Psiquiatria do Hospital das Clínicas da Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil)
  • Alexander E. VOISKOUNSKY (Moscow State University, Russia)
  • Aviv M. WEINSTEIN (Ariel University, Israel)
  • Anise WU (University of Macau, Macao, China)

 

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