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  • 1 Center for Psychiatric Medicine, North Andover, Massachusetts, USA
  • 2 Department of Psychiatry, Anatomy & Neurobiology, Boston VA and Boston University School of Medicine, Boston, Massachusetts, USA
  • 3 Department of Psychiatry, Global Integrated Services Unit of Vermont Center for Clinical & Translational Science, University of Vermont College of Medicine, Burlington, Vermont, USA
  • 4 Department of Holistic Medicine, G & G Health Care Services LLC, North Miami Beach, Florida, USA
  • 5 Center for Genomics and Applied Gene Technology, Institute of Integrative Omics and Applied Biotechnology (IIOAB), Nonakuri, Purba Medinipur, West Bengal, India
  • 6 Department of Nutrigenomics, LifeGen, Inc., Austin, Texas, USA
  • 7 Department of Psychiatry and McKnight Brain Institute, University of Florida, College of Medicine, Gainesville, Florida, USA
  • 8 Department of Clinical Neurology, PATH Foundation NY, New York, New York, USA
  • 9 Department of Management Science and Statistics, the University of Texas at San Antonio, San Antonio, Texas, USA
  • 10 Dominion Diagnostics, LLC, North Kingstown, Rhode Island, USA
  • 11 Department of Addiction Research & Therapy, Malibu Beach Recovery Center, Malibu Beach, California, USA
  • 12 Department of Psychiatry, College of Medicine, University of Florida, and McKnight Brain Institute, Gainesville, Florida, USA
Open access

Abstract

Background and aims

Many patients presenting multiple behaviors including drug and food abuse as well as other pathological repetitive unwanted activities such as gambling, self-mutilation and paraphilias may not be appropriately diagnosed. Here we present a case of a male presenting many of these seemingly diverse behaviors and finally diagnosed with reward deficiency syndrome (RDS) by his attending physician.

Methods

The use of the dopamine agonist, ropinirole after two weeks showed improvement in terms of sexual behavior but tolerance set in and was discontinued especially when an infraction occurred with the patient's insurance. In this article, we carefully explore the potential of ropinirole to downregulate dopamine receptors causing adenylate cyclase receptor supersensitivity and tolerance a feature of neurotransmitter cross-talk. Based on previous scientific evidence showing KB220Znutrigenomic amino-acid therapy (NAAT) to rapidly (post one-hour) activate dopaminergic pathways in both the pre-frontal cortex cingulate gyrus (relapse loci) and ventral tegmental area-caudate-accumbens-putamen (craving and emotion loci) the patient was prescribed NAAT.

Results and discussion

Within one week of utilization the repetitive paraphilia was eliminated. There were also a number of other positive effects such as enhanced focus that persisted even after the patient stopped using KB220Z suggesting neuroplasticity (e.g. altruistic thoughts). However, these observed profound benefits require more in-depth study, especially in a large cohort against a placebo. While this report focused on a rapid response rather than long-term benefits previously associated with NAAT, it is somewhat encouraging and longer term required follow-up and larger placebo controlled studies are warranted before any definitive conclusions could be gleaned from this case report.

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