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Katherine E. Gendreau MPH
Katherine E. Gendreau MPH
Yale University School of Medicine, New Haven, CT, USA
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Marc N. Potenza
Marc N. Potenza
Yale University School of Medicine, New Haven, CT, USA
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Abstract
Background/Aims
Studies have reported higher prevalences of four behavioral addictions (binge eating, compulsive shopping, hypersexuality, and pathological gambling) in dopamine agonist-treated Parkinson's disease relative to non-dopamine agonist-treated Parkinson's. However, recent case-control and epidemiological studies suggest that prevalences of behavioral addictions in dopamine agonist-treated Parkinson's may be similar to background population rates. This study tests that hypothesis by examining the FDA Adverse Event Reporting System (FAERS) for evidence of these associations, taking into account the potential impact of publicity on reporting rates.
Methods
FAERS reports in 2004 (pre-publicity for all but pathological gambling) and 2007 (post-publicity for all four behaviors) were analyzed. A threshold consisting of ≥3 cases, proportional reporting ratio ≥2, and χ2 with Yates' correction ≥4 was used to detect signals (drug-associated adverse reactions) involving any of five dopamine agonists and any of four behavioral addictions.
Results
No reports containing compulsive shopping and no signal for binge eating and dopamine agonists were found in either year. A weak signal was found for hypersexuality in 2004, with a stronger signal in 2007. A robust signal was found for pathological gambling in 2004, with a more robust signal in 2007.
Discussion/Conclusions
These results suggest that publicity may increase reporting rates in the FAERS. Findings for binge eating, compulsive shopping, and hypersexuality suggest that prevalences of these behaviors among those treated with dopamine agonists may be similar to background population rates and thus may not reflect an adverse safety signal. Further investigation of the relationship between dopamine agonists and behavioral addictions is warranted.
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Dr. Zsolt Demetrovics
Institute of Psychology, ELTE Eötvös Loránd University
Address: Izabella u. 46. H-1064 Budapest, Hungary
Phone: +36-1-461-2681
E-mail: jba@ppk.elte.hu
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| 2023 | |
|---|---|
| Web of Science | |
| Journal Impact Factor | 6.6 |
| Rank by Impact Factor | Q1 (Psychiatry) |
| Journal Citation Indicator | 1.59 |
| Scopus | |
| CiteScore | 12.3 |
| CiteScore rank | Q1 (Clinical Psychology) |
| SNIP | 1.604 |
| Scimago | |
| SJR index | 2.188 |
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| Journal of Behavioral Addictions | |
|---|---|
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| Subscription Information | Gold Open Access |
| Journal of Behavioral Addictions | |
|---|---|
| Language | English |
| Size | A4 |
| Year of Foundation |
2011 |
| Volumes per Year |
1 |
| Issues per Year |
4 |
| Founder | Eötvös Loránd Tudományegyetem |
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H-1053 Budapest, Hungary Egyetem tér 1-3. |
| Publisher | Akadémiai Kiadó |
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| ISSN | 2062-5871 (Print) |
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Senior editors
Editor(s)-in-Chief: Zsolt DEMETROVICS
Assistant Editor(s):
Csilla ÁGOSTON
Dana KATZ
Associate Editors
- Stephanie ANTONS (Universitat Duisburg-Essen, Germany)
- Joel BILLIEUX (University of Lausanne, Switzerland)
- Beáta BŐTHE (University of Montreal, Canada)
- Matthias BRAND (University of Duisburg-Essen, Germany)
- Daniel KING (Flinders University, Australia)
- Gyöngyi KÖKÖNYEI (ELTE Eötvös Loránd University, Hungary)
- Ludwig KRAUS (IFT Institute for Therapy Research, Germany)
- Marc N. POTENZA (Yale University, USA)
- Hans-Jurgen RUMPF (University of Lübeck, Germany)
- Ruth J. VAN HOLST (Amsterdam UMC, The Netherlands)
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- Sophia ACHAB (Faculty of Medicine, University of Geneva, Switzerland)
- Alex BALDACCHINO (St Andrews University, United Kingdom)
- Judit BALÁZS (ELTE Eötvös Loránd University, Hungary)
- Maria BELLRINGER (Auckland University of Technology, Auckland, New Zealand)
- Henrietta BOWDEN-JONES (Imperial College, United Kingdom)
- Damien BREVERS (University of Luxembourg, Luxembourg)
- Julius BURKAUSKAS (Lithuanian University of Health Sciences, Lithuania)
- Gerhard BÜHRINGER (Technische Universität Dresden, Germany)
- Silvia CASALE (University of Florence, Florence, Italy)
- Luke CLARK (University of British Columbia, Vancouver, B.C., Canada)
- Jeffrey L. DEREVENSKY (McGill University, Canada)
- Geert DOM (University of Antwerp, Belgium)
- Nicki DOWLING (Deakin University, Geelong, Australia)
- Hamed EKHTIARI (University of Minnesota, United States)
- Jon ELHAI (University of Toledo, Toledo, Ohio, USA)
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- Fernando FERNANDEZ-ARANDA (Bellvitge University Hospital, Barcelona, Spain)
- Naomi FINEBERG (University of Hertfordshire, United Kingdom)
- Sally GAINSBURY (The University of Sydney, Camperdown, NSW, Australia)
- Belle GAVRIEL-FRIED (The Bob Shapell School of Social Work, Tel Aviv University, Israel)
- Biljana GJONESKA (Macedonian Academy of Sciences and Arts, Republic of North Macedonia)
- Marie GRALL-BRONNEC (University Hospital of Nantes, France)
- Jon E. GRANT (University of Minnesota, USA)
- Mark GRIFFITHS (Nottingham Trent University, United Kingdom)
- Joshua GRUBBS (University of New Mexico, Albuquerque, NM, USA)
- Anneke GOUDRIAAN (University of Amsterdam, The Netherlands)
- Susumu HIGUCHI (National Hospital Organization Kurihama Medical and Addiction Center, Japan)
- David HODGINS (University of Calgary, Canada)
- Eric HOLLANDER (Albert Einstein College of Medicine, USA)
- Zsolt HORVÁTH (Eötvös Loránd University, Hungary)
- Susana JIMÉNEZ-MURCIA (Clinical Psychology Unit, Bellvitge University Hospital, Barcelona, Spain)
- Yasser KHAZAAL (Geneva University Hospital, Switzerland)
- Orsolya KIRÁLY (Eötvös Loránd University, Hungary)
- Chih-Hung KO (Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Taiwan)
- Shane KRAUS (University of Nevada, Las Vegas, NV, USA)
- Hae Kook LEE (The Catholic University of Korea, Republic of Korea)
- Bernadette KUN (Eötvös Loránd University, Hungary)
- Katerina LUKAVSKA (Charles University, Prague, Czech Republic)
- Giovanni MARTINOTTI (‘Gabriele d’Annunzio’ University of Chieti-Pescara, Italy)
- Gemma MESTRE-BACH (Universidad Internacional de la Rioja, La Rioja, Spain)
- Astrid MÜLLER (Hannover Medical School, Germany)
- Daniel Thor OLASON (University of Iceland, Iceland)
- Ståle PALLESEN (University of Bergen, Norway)
- Afarin RAHIMI-MOVAGHAR (Teheran University of Medical Sciences, Iran)
- József RÁCZ (Hungarian Academy of Sciences, Hungary)
- Michael SCHAUB (University of Zurich, Switzerland)
- Marcantanio M. SPADA (London South Bank University, United Kingdom)
- Daniel SPRITZER (Study Group on Technological Addictions, Brazil)
- Dan J. STEIN (University of Cape Town, South Africa)
- Sherry H. STEWART (Dalhousie University, Canada)
- Attila SZABÓ (Eötvös Loránd University, Hungary)
- Hermano TAVARES (Instituto de Psiquiatria do Hospital das Clínicas da Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil)
- Wim VAN DEN BRINK (University of Amsterdam, The Netherlands)
- Alexander E. VOISKOUNSKY (Moscow State University, Russia)
- Aviv M. WEINSTEIN (Ariel University, Israel)
- Anise WU (University of Macau, Macao, China)
- Ágnes ZSILA (ELTE Eötvös Loránd University, Hungary)
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