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  • 1 Orvosi és Gyógyszerészeti Egyetem (UMF Tg. Mures) str. Gh. Marinescu nr. 38 Tg. Mures România
  • 2 DRC Gyógyszervizsgáló Központ Kft. Balatonfüred
  • 3 Semmelweis Orvostudományi Egyetem Kórélettani Intézet Budapest
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Célkitűzés: A FABP2 (intestinal fatty acid–binding protein)-gén a vékonybél hámsejtjeiben található és a zsírsavak metabolizmusában vélhetően fontos szerepet betöltő fehérjét kódol. A gén anyagcserezavarokra hajlamosító A54T-polimorfizmusának kapcsolatát vizsgáltuk az IDF által 2005-ben ajánlott kritériumok alapján diagnosztizált metabolikus szindrómával a marosvásárhelyi populációnál. Anyag és módszer – Eset-kontroll tanulmányt végeztünk 144 metabolikus szindrómás betegnél és 73 hasonló korú és életmódot folytató egészséges személynél. Az inzulinérzékenységet HOMA- és QUICKI-indexek számítása révén ítéltük meg, míg a génpolimorfizmust PCR és ezt követő Hha I restrikciós enzimmel történő hasítás segítségével vizsgáltuk. Eredmények: A T54 gyakrabban fordult elő a metabolikus szindrómás betegeknél, mint az egészséges kontrollcsoportnál (35,71% vs. 28,08%, p < 0,05). A T54-allél jelenlétében tapasztalt megbetegedési kockázat enyhe, de statisztikailag szignifikáns, és kifejezettebb homozigóták esetében (TT vs. AT + OR = 4,31, CI 95% 1,21–5,29, p = 0,015 és TT vs. OR = 4,61, CI95%: 1,24–7,03, p = 0,0195). Nem tapasztaltunk statisztikailag szignifikáns különbséget a követett anyagcsere-paraméterekben a három eltérő genotípusnak megfelelően a két vizsgálati csoportban. Következtetések: Eredményeink alapján a FABP2-gén T54-allélja egy poligénes rendszer keretén belül szerepet játszhat a metabolikus szindrómára való hajlam kialakításában.

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