View More View Less
  • 1 Semmelweis Egyetem, Általános Orvostudományi Kar I. Szülészeti és Nőgyógyászati Klinika Budapest Baross u. 27. 1088
Restricted access

Purchase article

USD  $25.00

1 year subscription (Individual Only)

USD  $1,070.00

Bevezetés: A neonatális szepszis mortalitása magas, és koraszülöttek esetén a szepszis rizikója emelkedik a születési súly csökkenésével. Anyag és módszer: A szerzők gyorsteszt segítségével 12 érett újszülött és 60 igen kis súlyú (VLBW) koraszülött interleukin-6-vérszintjét határozták meg a C-reaktív protein vizsgálatával egyidejűleg, akiket a Semmelweis Egyetem I. Számú Szülészeti és Nőgyógyászati Klinikájának Neonatális Intenzív Centrumában kezeltek 2005-ben és 2006-ban. A szérum-IL-6 meghatározása gyorsteszt segítségével történt (Milenia Quickline IL-6, PicoScan system). Eredmények: Vizsgálataikban a szérum-interleukin-6- és CRP-meghatározás korrelált. A szérum-IL-6-meghatározás szenzitivitása a CRP-értékkel együtt az általuk vizsgált betegcsoportban 100% volt, álnegatív eset nem fordult elő. A vizsgálat pozitív prediktív értéke 93%. Adataikat Mann–Whitney-teszt segítségével analizálták (SPSS Statistical Software Package, Chicago, IL, USA). Szignifikáns különbség volt az igazolt szepszis és az infekciós betegcsoport IL-6-értékei között ( p = 0,048), valamint az infekciós és nem infekciós csoport interleukin-6-értékei között ( p < 0,005). Következtetések: Az igen kis súlyúak nem specifikus infekciós tünetekhez hasonló reakcióit értékelve, a szeptikus és nem infekciós esetek elkülönítése a neonatális morbiditás és mortalitás csökkentése érdekében is fontos szempont, a költségek csökkentésével egyidejűleg.

  • Romero, R., Yoon, B. H., Major, M. és mtsa: The diagnostic and prognostic value of amniotic fluid white blod cell count, IL-6 and gram stain in patients with preterm labor and intact membranes. Am. J. Obstet. Gynecol., 1993, 169 , 805–816.

    Major M. , 'The diagnostic and prognostic value of amniotic fluid white blod cell count, IL-6 and gram stain in patients with preterm labor and intact membranes ' (1993 ) 169 Am. J. Obstet. Gynecol. : 805 -816.

    • Search Google Scholar
  • Hatzidaki, E., Gourgiotis, D., Manoura, A.: Interleukin-6 in preterm premature rupture of membranes as an indicator of neonatal outcome. Acta Obst. Gyn. Scand., 2005, 84 , 632–638.

    Manoura A. , 'Interleukin-6 in preterm premature rupture of membranes as an indicator of neonatal outcome ' (2005 ) 84 Acta Obst. Gyn. Scand. : 632 -638.

    • Search Google Scholar
  • Krueger, M., Nauck, M. S., Sang, S. és mtsai: Cord blood levels of Interleukin-6 and Interleukin-8 for the immediate diagnosis of early-onset infection in premature infants. Biol. Neonate., 2001, 80 , 118–123.

    Sang S. , 'Cord blood levels of Interleukin-6 and Interleukin-8 for the immediate diagnosis of early-onset infection in premature infants ' (2001 ) 80 Biol. Neonate. : 118 -123.

    • Search Google Scholar
  • Laborada, G., Rego, M., Jain, A. és mtsai: Diagnostic value of cytokines and C-reactive protein in the first 24 hours of neonatal sepsis. Am. J. Perinatol., 2003, 20 , 491–501.

    Jain A. , 'Diagnostic value of cytokines and C-reactive protein in the first 24 hours of neonatal sepsis ' (2003 ) 20 Am. J. Perinatol. : 491 -501.

    • Search Google Scholar
  • Procianoy, R. S., Silveira, R. C.: The role of sample collection timing on interleukin-6 levels in early-onset neonatal sepsis. J. Pediatr., 2004, 80 , 407–410.

    Silveira R. C. , 'The role of sample collection timing on interleukin-6 levels in early-onset neonatal sepsis ' (2004 ) 80 J. Pediatr. : 407 -410.

    • Search Google Scholar
  • Resch, B., Gusenleitner, W., Muller, W. D.: Procalcitonin and interleukin-6 in the diagnosis of early-onset sepsis of the neonate. Acta Paediatr., 2003, 92 , 243–245.

    Muller W. D. , 'Procalcitonin and interleukin-6 in the diagnosis of early-onset sepsis of the neonate ' (2003 ) 92 Acta Paediatr. : 243 -245.

    • Search Google Scholar
  • Arnon, S., Litmanovitz, I., Regev, R.: Serum amyloid A protein is a useful inflammatory marker during late-onset sepsis in preterm infants. Biol. Neonate., 2005, 87 , 105–110.

    Regev R. , 'Serum amyloid A protein is a useful inflammatory marker during late-onset sepsis in preterm infants ' (2005 ) 87 Biol. Neonate. : 105 -110.

    • Search Google Scholar
  • Verboon-Maciolek, M. A., Thijsen, S. F., Hemels, M. A. C.: Inflammatory mediators for the diagnosis and treatment of sepsis in early infancy. Ped. Research., 2006, 59 , 457–461.

    Hemels M. A. C. , 'Inflammatory mediators for the diagnosis and treatment of sepsis in early infancy ' (2006 ) 59 Ped. Research. : 457 -461.

    • Search Google Scholar
  • Kotecha, S., Wilson, L., Wangoo, A. és mtsai: Increase in interleukin-1 beta and IL-6 in bronchoalveolar lavage fluid obtained from infants with chronic lung disease of prematurity. Ped. Research., 1996, 40 , 50–256.

    Wangoo A. , 'Increase in interleukin-1 beta and IL-6 in bronchoalveolar lavage fluid obtained from infants with chronic lung disease of prematurity ' (1996 ) 40 Ped. Research. : 50 -256.

    • Search Google Scholar
  • Viscardi, R. M., Muhumuza, C. K., Rodriguez, A. és mtsai: Inflammatory markers in inrauterine and fetal blood and cerebrospinal fluid compartments are associated with adverse pulmonary and neurologic outcomes in preterm infants. Ped. Research., 2004, 55 , 1009–1017.

    Rodriguez A. , 'Inflammatory markers in inrauterine and fetal blood and cerebrospinal fluid compartments are associated with adverse pulmonary and neurologic outcomes in preterm infants ' (2004 ) 55 Ped. Research. : 1009 -1017.

    • Search Google Scholar
  • Zanardo, V., Vedovato, S., Trevisanuto, D. és mtsai: Leukemoid reaction an BPD: A primary inflammatory mechanism? Pediatrics, 2005, 116 , 1260–1261.

    Trevisanuto D. , 'Leukemoid reaction an BPD: A primary inflammatory mechanism? ' (2005 ) 116 Pediatrics : 1260 -1261.

    • Search Google Scholar
  • Baier, R. J., Loggins, J., Yanamandra, K.: IL-10, IL-6 and CD14 polymorphisms and sepsis outcome in ventilated very low birth weight infants. B. M. C. Med., 2006, 12 , 4–10.

    Yanamandra K. , 'IL-10, IL-6 and CD14 polymorphisms and sepsis outcome in ventilated very low birth weight infants ' (2006 ) 12 B. M. C. Med. : 4 -10.

    • Search Google Scholar
  • Miralles, R., Hodge, R., Mcparland, P. és mtsai: Relationship between antenatal inflammation and antenatal infection identified by detection of microbial genes by polymerase chain reaction. Ped. Research, 2005, 57 , 570–577.

    Mcparland P. , 'Relationship between antenatal inflammation and antenatal infection identified by detection of microbial genes by polymerase chain reaction ' (2005 ) 57 Ped. Research : 570 -577.

    • Search Google Scholar
  • Sipahi, T., Pocan, H., Akar, N.: Effect of various genetic polymorphisms on the incidence and outcome of severe sepsis. Clin. Appl. Thromb. Hemost., 2006, 12 , 47–54.

    Akar N. , 'Effect of various genetic polymorphisms on the incidence and outcome of severe sepsis ' (2006 ) 12 Clin. Appl. Thromb. Hemost. : 47 -54.

    • Search Google Scholar
  • Heep, A., Behrendt, D., Nitsch, P.: Increased serum level of IL-6 are associated with severe intraventricular hemorrhagein extremely premature infants. Arch. Dis. Child. Fetal. Neonatal, 2003, 88 , 501–504.

    Nitsch P. , 'Increased serum level of IL-6 are associated with severe intraventricular hemorrhagein extremely premature infants ' (2003 ) 88 Arch. Dis. Child. Fetal. Neonatal : 501 -504.

    • Search Google Scholar
  • Kassal, R., Anwar, M., Kashlan, F. és mtsai: Umbilical vein interleukin-6 levels in very low birth weight infants developing intraventricular hemorrhage. Brain Dev., 2005, 27 , 483–487.

    Kashlan F. , 'Umbilical vein interleukin-6 levels in very low birth weight infants developing intraventricular hemorrhage ' (2005 ) 27 Brain Dev. : 483 -487.

    • Search Google Scholar
  • Kaukola, T., Herva, R., Perhomaa, M. és mtsai: Population cohort associating chorioamnionitis, cord inflammatory cytokines and neurologic outcome in very preterm, extremely low birth weight infants. Pediatr. Res., 2006, 59 , 478–483.

    Perhomaa M. , 'Population cohort associating chorioamnionitis, cord inflammatory cytokines and neurologic outcome in very preterm, extremely low birth weight infants ' (2006 ) 59 Pediatr. Res. : 478 -483.

    • Search Google Scholar
  • Krediet, T. G., Kavelaars, A., Vreman, H. J. és mtsai: Respiratory distress syndrome-associated inflammation is related to early but not late peri/intraventricular hemorrhage in preterm infants. J. Pediatr., 2006, 148 , 740–746.

    Vreman H. J. , 'Respiratory distress syndrome-associated inflammation is related to early but not late peri/intraventricular hemorrhage in preterm infants ' (2006 ) 148 J. Pediatr. : 740 -746.

    • Search Google Scholar
  • Moore, M. R., Schrag, S. J., Schuchat, A.: Effects of intrapartum antimicrobial prophylaxis for prevention of group-B-Streptococcal disease on the incidence and ecology of early-onset neonatal sepsis. Lancet Infect. Dis., 2003, 3 , 201–213.

    Schuchat A. , 'Effects of intrapartum antimicrobial prophylaxis for prevention of group-B-Streptococcal disease on the incidence and ecology of early-onset neonatal sepsis ' (2003 ) 3 Lancet Infect. Dis. : 201 -213.

    • Search Google Scholar
  • Huang, J., Upadhyay, U. M., Tamargo, R. J.: Inflammation in stroke and focal cerebral ischemia. Surg. Neurol., 2006, 66 , 232–245.

    Tamargo R. J. , 'Inflammation in stroke and focal cerebral ischemia ' (2006 ) 66 Surg. Neurol. : 232 -245.

    • Search Google Scholar
  • Zhu, Y., Zhou, Y. H., Wang, M. Y. és mtsai: Blockade of CD86 signaling facilitates a Th2 bias at the maternal-fetal interface and expands peripheral CD4 + CD25 + regulatory T cells to rescue abortion-prone fetuses. Biol. Reprod., 2005, 72 , 338–345.

    Wang M. Y. , 'Blockade of CD86 signaling facilitates a Th2 bias at the maternal-fetal interface and expands peripheral CD4 + CD25 + regulatory T cells to rescue abortion-prone fetuses ' (2005 ) 72 Biol. Reprod. : 338 -345.

    • Search Google Scholar
  • Burns, J. P.: Septic shock in the pediatric patient. Pathogenesis and novel treatments. Ped. Emerg. Care, 2003, 19 , 112–115.

    Burns J. P. , 'Septic shock in the pediatric patient. Pathogenesis and novel treatments ' (2003 ) 19 Ped. Emerg. Care : 112 -115.

    • Search Google Scholar

Monthly Content Usage

Abstract Views Full Text Views PDF Downloads
Nov 2020 24 8 4
Dec 2020 26 0 1
Jan 2021 12 0 2
Feb 2021 20 0 3
Mar 2021 51 1 5
Apr 2021 27 0 0
May 2021 0 0 0