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  • 1 Semmelweis Egyetem, Általános Orvostudományi Kar II. Belgyógyászati Klinika Budapest Szentkirályi u. 46. 1088
  • 2 Magyar Tudományos Akadémia Molekuláris Medicina Kutatócsoport Budapest
Open access

A DNS-metiláció szerepet játszik a daganatképződés korai szakaszában. Kimutatása szövetből, székletből és perifériás vérből egyaránt lehetséges. A szeptin-9 érzékeny metilációs jelző, amelyet több daganatban, mint emlő- és petefészekrákban, valamint neurológiai és hematológiai betegségekben is vizsgáltak. A szeptinproteinek fontos szerephez jutnak a sejtváz organizációjától az embrionális mintázat kialakulásáig. Napjainkban intenzív kutatások folynak a szeptin-9 fokozott metilációja és a vastagbélrák kialakulása közötti összefüggés felderítéseire.

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