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  • 1 Semmelweis Egyetem, Gyógyszertudományi Kar Egyetemi Gyógyszertár Gyógyszerügyi Szervezési Intézet Budapest

A gyógyszeres kezelés hiányos compliance-e, valamint perzisztenciája jelentős problémát jelent a krónikus obstruktív tüdőbetegek optimális terápiájának kialakításában – derül ki a szerzők szisztematikus irodalomelemzéséből. A túlzott gyógyszerhasználat ugyanúgy, mint a csökkent gyógyszerbevitel inadekvát terápiát meghatározó fontos tényező. A beteg-együttműködés hiánya jelentősen növeli az exacerbatiók előfordulását, a kórházi kezelések számát, a mortalitási rátát, valamint csökkenti a betegek életminőségét. Célszerű a betegjellemzőket, a várható compliance-t, illetve perzisztenciát már a gyógyszer kiválasztásakor figyelembe venni. Hatékonyabb orvos–beteg kapcsolattal, megfelelő betegtájékoztatással ugyancsak javítható a kezelések hatékonysága.

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  • Jónás J.: A pulmonológiai intézmények 2007. évi epidemiológiai és működési adatai. Országos Korányi Tbc és Pulmonológiai Intézet, 2008.

    Jónás J. , '', in A pulmonológiai intézmények 2007. évi epidemiológiai és működési adatai , (2008 ) -.

  • Holguin, F., Folch, E., Redd, S. C. és mtsa: Comorbidity and mortality in COPD-related hospitalizations in the United States, 1979 to 2001. Chest, 2005, 128 , 2005–2011.

    Redd S. C. , 'Comorbidity and mortality in COPD-related hospitalizations in the United States, 1979 to 2001 ' (2005 ) 128 Chest : 2005 -2011.

    • Search Google Scholar
  • Rabe, K. F., Hurd, S., Anzueto, A. és mtsai: Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am. J. Respir. Crit. Care Med., 2007, 176 , 532–555.

    Anzueto A. , 'Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary ' (2007 ) 176 Am. J. Respir. Crit. Care Med. : 532 -555.

    • Search Google Scholar
  • WHO: Adherence to long-term therapies: evidence for action. World Health Organization, 2003, 1–59.

  • Regueiro, C. R., Hamel, M. B., Davis, R. B. és mtsai: A comparison of generalist and pulmonologist care for patients hospitalized with severe chronic obstructive pulmonary disease: Resource intensity, hospital costs, and survival. American Journal of Medicine, 1998, 105 , 366–372.

    Davis R. B. , 'A comparison of generalist and pulmonologist care for patients hospitalized with severe chronic obstructive pulmonary disease: Resource intensity, hospital costs, and survival ' (1998 ) 105 American Journal of Medicine : 366 -372.

    • Search Google Scholar
  • Bourbeau, J., Bartlett, S. J.: Patient adherence in COPD. Thorax, 2008, 63 , 831–838.

    Bartlett S. J. , 'Patient adherence in COPD ' (2008 ) 63 Thorax : 831 -838.

  • Seemungal, T. A. R., Donaldson, G. C., Paul, E. A. és mtsai: Effect of exacerbation on quality of life in patients with chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med., 1998, 157 , 1418–1422.

    Paul E. A. , 'Effect of exacerbation on quality of life in patients with chronic obstructive pulmonary disease ' (1998 ) 157 Am. J. Respir. Crit. Care Med. : 1418 -1422.

    • Search Google Scholar
  • Koncz T.: A beteg együttműködés egészség-gazdaságtani jelentősége. In Egészség-gazdaságtan. Szerk.: Gulácsi L. Medicina Könyvkiadó, 2005, 401–435.

    Koncz T. , '', in Egészség-gazdaságtan , (2005 ) -.

  • Haynes, R. B., Montague, P., Oliver, T. és mtsai: Interventions for helping patients to follow prescriptions for medications. Cochrane Database Syst. Rev., 2000, 2.

    Oliver T. , 'Interventions for helping patients to follow prescriptions for medications ' (2000 ) Cochrane Database Syst. Rev. : 2 -.

    • Search Google Scholar
  • Cleemput, I., Kesteloot, K., DeGeest, S.: A review of the literature on the economics of noncompliance. Room for methodological improvement. Health Policy, 2002, 59 , 65–94.

    DeGeest S. , 'A review of the literature on the economics of noncompliance. Room for methodological improvement ' (2002 ) 59 Health Policy : 65 -94.

    • Search Google Scholar
  • Cramer, J. A., Roy, A., Burrell, A. és mtsai: Medication compliance and persistence: Terminology and definitions. Value in Health, 2008, 11 , 44–47.

    Burrell A. , 'Medication compliance and persistence: Terminology and definitions ' (2008 ) 11 Value in Health : 44 -47.

    • Search Google Scholar
  • Peterson, A. M., Nau, D. P., Cramer, J. A. és mtsai: A checklist for medication compliance and persistence studies using retrospective databases. Value in Health, 2007, 10 , 3–12.

    Cramer J. A. , 'A checklist for medication compliance and persistence studies using retrospective databases ' (2007 ) 10 Value in Health : 3 -12.

    • Search Google Scholar
  • Kennedy, J., Tuleu, I., Mackay, K.: Unfilled prescriptions of medicare beneficiaries: Prevalence, reasons, and types of medicines prescribed. Journal of Managed Care Pharmacy, 2008, 14 , 553–560.

    Mackay K. , 'Unfilled prescriptions of medicare beneficiaries: Prevalence, reasons, and types of medicines prescribed ' (2008 ) 14 Journal of Managed Care Pharmacy : 553 -560.

    • Search Google Scholar
  • Breekveldt-Postma, N. S., Gerrits, C. M. J. M., Lammers, J. W. J. és mtsai: Persistence with inhaled corticosteroid therapy in daily practice. Respir. Med., 2004, 98 , 752–759.

    Lammers J. W. J. , 'Persistence with inhaled corticosteroid therapy in daily practice ' (2004 ) 98 Respir. Med. : 752 -759.

    • Search Google Scholar
  • Jung, E., Pickard, A. S., Salmon, J. W. és mtsai: Medication adherence and persistence in the last year of life in COPD patients. Respir. Med., 2009, 103 , 525–534.

    Salmon J. W. , 'Medication adherence and persistence in the last year of life in COPD patients ' (2009 ) 103 Respir. Med. : 525 -534.

    • Search Google Scholar
  • Cramer, J. A., Benedict, A., Muszbek, N. és mtsai: The significance of compliance and persistence in the treatment of diabetes, hypertension and dyslipidaemia: A review. Int. J. Clin. Pract., 2008, 62 , 76–87.

    Muszbek N. , 'The significance of compliance and persistence in the treatment of diabetes, hypertension and dyslipidaemia: A review ' (2008 ) 62 Int. J. Clin. Pract. : 76 -87.

    • Search Google Scholar
  • Breekveldt-Postma, N. S., Koerselman, J., Erkens, J. A. és mtsai: Enhanced persistence with tiotropium compared with other respiratory drugs in COPD. Respir. Med., 2007, 101 , 1398–1405.

    Erkens J. A. , 'Enhanced persistence with tiotropium compared with other respiratory drugs in COPD ' (2007 ) 101 Respir. Med. : 1398 -1405.

    • Search Google Scholar
  • Cramer, J. A., Bradley-Kennedy, C., Scalera, A.: Treatment persistence and compliance with medications for chronic obstructive pulmonary disease. Can. Respir. J., 2007, 14 , 25–29.

    Scalera A. , 'Treatment persistence and compliance with medications for chronic obstructive pulmonary disease ' (2007 ) 14 Can. Respir. J. : 25 -29.

    • Search Google Scholar
  • Restrepo, R. D., Alvarez, M. T., Wittnebel, L. D. és mtsai: Medication adherence issues in patients treated for COPD. Int. J. Chron. Obstruct. Pulmon. Dis., 2008, 3 , 371–384.

    Wittnebel L. D. , 'Medication adherence issues in patients treated for COPD ' (2008 ) 3 Int. J. Chron. Obstruct. Pulmon. Dis. : 371 -384.

    • Search Google Scholar
  • Krigsman, K., Moen, J., Nilsson, J. L. G. és mtsa: Refill adherence by the elderly for asthma/chronic obstructive pulmonary disease drugs dispensed over a 10-year period. Journal of Clinical Pharmacy and Therapeutics, 2007, 32 , 603–611.

    Nilsson J. L. G. , 'Refill adherence by the elderly for asthma/chronic obstructive pulmonary disease drugs dispensed over a 10-year period ' (2007 ) 32 Journal of Clinical Pharmacy and Therapeutics : 603 -611.

    • Search Google Scholar
  • Krigsman, K., Nilsson, J. L. G., Ring, L.: Refill adherence for patients with asthma and COPD: Comparison of a pharmacy record database with manually collected repeat prescriptions. Pharmacoepidemiology and Drug Safety, 2007, 16 , 441–448.

    Ring L. , 'Refill adherence for patients with asthma and COPD: Comparison of a pharmacy record database with manually collected repeat prescriptions ' (2007 ) 16 Pharmacoepidemiology and Drug Safety : 441 -448.

    • Search Google Scholar
  • Yeo, J., Karimova, G., Bansal, S.: Co-morbidity in older patients with COPD – Its impact on health service utilisation and quality of life, a community study. Age and Ageing, 2006, 35 , 33–37.

    Bansal S. , 'Co-morbidity in older patients with COPD – Its impact on health service utilisation and quality of life, a community study ' (2006 ) 35 Age and Ageing : 33 -37.

    • Search Google Scholar
  • Krigsman, K., Nilsson, J. L. G., Ring, L.: Adherence to multiple drug therapies: Refill adherence to concomitant use of diabetes and asthma/COPD medication. Pharmacoepidemiology and Drug Safety, 2007, 16 , 1120–1128.

    Ring L. , 'Adherence to multiple drug therapies: Refill adherence to concomitant use of diabetes and asthma/COPD medication ' (2007 ) 16 Pharmacoepidemiology and Drug Safety : 1120 -1128.

    • Search Google Scholar
  • Corden, Z. M., Bosley, C. M., Rees, P. J. és mtsai: Home nebulized therapy for patients with COPD: Patient compliance with treatment and its relation to quality of life. Chest, 1997, 112 , 1278–1282.

    Rees P. J. , 'Home nebulized therapy for patients with COPD: Patient compliance with treatment and its relation to quality of life ' (1997 ) 112 Chest : 1278 -1282.

    • Search Google Scholar
  • George, J., Kong, D. C. M., Thoman, R. és mtsa: Factors associated with medication nonadherence in patients with COPD. Chest, 2005, 128 , 3198–3204.

    Thoman R. , 'Factors associated with medication nonadherence in patients with COPD ' (2005 ) 128 Chest : 3198 -3204.

    • Search Google Scholar
  • Rand, C. S.: Patient adherence with COPD therapy. European Respiratory Review, 2005, 14 , 97–101.

    Rand C. S. , 'Patient adherence with COPD therapy ' (2005 ) 14 European Respiratory Review : 97 -101.

    • Search Google Scholar
  • Van Manen, J. G., Bindels, P. J. E., Dekker, F. W. és mtsai: Risk of depression in patients with chronic obstructive pulmonary disease and its determinants. Thorax, 2002, 57 , 412–416.

    Dekker F. W. , 'Risk of depression in patients with chronic obstructive pulmonary disease and its determinants ' (2002 ) 57 Thorax : 412 -416.

    • Search Google Scholar
  • Apter, A. J., Reisine, S. T., Affleck, G. és mtsai: Adherence with twice-daily dosing of inhaled steroids: Socioeconomic and health-belief differences. Am. J. Respir. Crit. Care Med., 1998, 157 , 1810–1817.

    Affleck G. , 'Adherence with twice-daily dosing of inhaled steroids: Socioeconomic and health-belief differences ' (1998 ) 157 Am. J. Respir. Crit. Care Med. : 1810 -1817.

    • Search Google Scholar
  • Chambers, C. V., Markson, L., Diamond, J. J. és mtsai: Health beliefs and compliance with inhaled corticosteroids by asthmatic patients in primary care practices. Respiratory Medicine, 1999, 93 , 88–94.

    Diamond J. J. , 'Health beliefs and compliance with inhaled corticosteroids by asthmatic patients in primary care practices ' (1999 ) 93 Respiratory Medicine : 88 -94.

    • Search Google Scholar
  • Dimatteo, M. R.: Psychology of health illness and medical care: An individual perspective. Thomson Brooks/Cole, 1991.

  • Onyirimba, F., Apter, A., Reisine, S. és mtsai: Direct clinician-to-patient feedback discussion of inhaled steroid use: Its effect on adherence. Annals of Allergy, Asthma and Immunology, 2003, 90 , 411–415.

    Reisine S. , 'Direct clinician-to-patient feedback discussion of inhaled steroid use: Its effect on adherence ' (2003 ) 90 Annals of Allergy, Asthma and Immunology : 411 -415.

    • Search Google Scholar
  • Bailey, W. C., Richards, J. M. Jr., Brooks, C. M. és mtsai: A randomized trial to improve self-management practices of adults with asthma. Arch. Intern. Med., 1990, 150 , 1664–1668.

    Brooks C. M. , 'A randomized trial to improve self-management practices of adults with asthma ' (1990 ) 150 Arch. Intern. Med. : 1664 -1668.

    • Search Google Scholar
  • Put, C., Van den Bergh, O., Lemaigre, V. és mtsai: Evaluation of an individualised asthma programme directed at behavioural change. Eur. Respir. J., 2003, 21 , 109–115.

    Lemaigre V. , 'Evaluation of an individualised asthma programme directed at behavioural change ' (2003 ) 21 Eur. Respir. J. : 109 -115.

    • Search Google Scholar
  • Hesselink, A. E., Penninx, B. W. J. H., Van Der Windt, D. A. W. M. és mtsai: Effectiveness of an education programme by a general practice assistant for asthma and COPD patients: Results from a randomised controlled trial. Patient Educ. Couns., 2004, 55 , 121–128.

    Windt D. A. W. M. , 'Effectiveness of an education programme by a general practice assistant for asthma and COPD patients: Results from a randomised controlled trial ' (2004 ) 55 Patient Educ. Couns. : 121 -128.

    • Search Google Scholar
  • Gallefoss, F.: The effects of patient education in COPD in a 1-year follow-up randomised, controlled trial. Patient Education and Counseling, 2004, 52 , 259–266.

    Gallefoss F. , 'The effects of patient education in COPD in a 1-year follow-up randomised, controlled trial ' (2004 ) 52 Patient Education and Counseling : 259 -266.

    • Search Google Scholar
  • Worth, H., Dhein, Y.: Does patient education modify behaviour in the management of COPD? Patient Education and Counseling, 2004, 52 , 267–270.

    Dhein Y. , 'Does patient education modify behaviour in the management of COPD? ' (2004 ) 52 Patient Education and Counseling : 267 -270.

    • Search Google Scholar
  • Petrilla, A. A., Benner, J. S.: Critical evaluation of interventions to enhance patient compliance with chronic medications. Value in Health, 2003, 6 , 200.

    Benner J. S. , 'Critical evaluation of interventions to enhance patient compliance with chronic medications ' (2003 ) 6 Value in Health : 200 -.

    • Search Google Scholar