Orvosi Hetilap
Volume/Issue:
Volume 150: Issue 9
Effectiveness of new, once-daily 5-aminosalicylic acid in the treatment of ulcerative colitis
Authors: Péter László Lakatos 1 and László Lakatos 2
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  • 1 Semmelweis Egyetem, Általános Orvostudományi Kar I. Belgyógyászati Klinika Budapest Korányi S. 2/A 1083
  • 2 Csolnoky Ferenc Megyei Kórház I. Belgyógyászati Osztály Veszprém
DOI:
https://doi.org/10.1556/oh.2009.28555
Page Count:
397–404
Publication Date:
01 Mar 2009
Online Publication Date:
19 Feb 2009
Article Category:
Research Article
Open access

Az 5-aminoszalicilsav- (5-ASA-) készítmények mind a mai napig a colitis ulcerosa terápiájának alapvető gyógyszereit jelentik. Számos orálisan adható 5-ASA-készítmény van forgalomban, beleértve az azo-kötést tartalmazó prodrugokat (például sulfalazin, olsalazin, balzalazid), valamint a mesalazin elnyújtott és kontrollált hatóanyag-kibocsátású kiszereléseit. Az orális terápia hatékonysága a beteg jó együttműködésén is múlik, amelynek gátat szabhat a naponta többször adott, nagyszámú tabletta bevétele. Ez a tényező a colitis ulcerosában szenvedő betegek terápiájának pontos betartásában jelentős akadályt képezhet. A közelmúltban egy új, naponta egyszer adandó, egyedülálló multimátrix mesalazinkészítmény és a szintén naponta egy alkalommal adható mesalazingranulátum hatékonynak bizonyult az enyhe-közepes súlyosságú colitis ulcerosa indukciós és fenntartó terápiájában. A mellékhatásprofil ugyanakkor nem különbözött a hagyományos mesalazinkészítményektől. A ritka adagolás a betegek jobb hosszú távú compliance-e által hozzájárulhat a betegek hatékonyabb kezeléséhez és várhatóan a colitis ulcerosával kapcsolatos colorectalis carcinoma rizikójának csökkentéséhez. A szerzők az alábbi közleményben összefoglalják az új, naponta egyszer adandó mesalazinkészítmények rövid és közepes távú hatékonyságával és biztonságosságával kapcsolatban elérhető irodalmi adatokat.

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Cover Orvosi Hetilap
Orvosi Hetilap
Print ISSN:
0030-6002
Online ISSN:
1788-6120
Keywords:
colitis ulcerosa; terápia; 5-aminoszalicilsav; mesalazin; Multi Matrix System; naponta egyszer adandó; együttműködés; ulcerative colitis; therapy; 5-aminosalicylate; mesalazine; Multi Matrix System; once-daily; compliance

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