View More View Less
  • 1 Semmelweis Egyetem, Általános Orvostudományi Kar Genetikai-Sejt és Immunbiológiai Intézet Budapest
  • 2 Semmelweis Egyetem, Általános Orvostudományi Kar Radiológiai és Onkoterápiás Klinika, Onkológiai Gondozó Budapest
  • 3 Semmelweis Egyetem, Általános Orvostudományi Kar Magatartástudományi Intézet Budapest
  • 4 Quintess Egészség Központ Budapest Páfrány u 22. 1026
  • 5 Debreceni Egyetem, Általános Orvostudományi Kar Biokémiai és Molekuláris Biológiai Intézet Debrecen
Open access

A 2009. évi orvosi Nobel-díjat a telomerák és a telomeráz enzim felfedezéséért és az ezekkel kapcsolatos úttörő kutatásokért három, Amerikában dolgozó tudós kapta megosztva. Nem régóta az is ismert, hogy bizonyos életmód- és táplálkozásbeli változások (Ornish-féle életmódváltozás), magatartásbeli, pszichológiai tényezők, valamint a telomerarövidülés között bizonyított kapcsolat létezik. Az összefoglalóban ezen összefüggések molekuláris, sejtbiológiai, életmódbeli és magatartási vonatkozásait, valamint ezek lehetséges összefüggéseit mutatják be.

If the inline PDF is not rendering correctly, you can download the PDF file here.

  • Vogel, G., Pennisi, E.: Physiology Nobel. U.S. Researchers recognized for work on telomeres. Science, 2009, 326 , 212–213.

    Pennisi E. , 'Physiology Nobel. U.S. Researchers recognized for work on telomeres ' (2009 ) 326 Science : 212 -213.

    • Search Google Scholar
  • Makovets, S., Blackburn, E. H.: DNA damage signalling prevents deleterious telomere addition at DNA breaks. Nat. Cell Biol., 2009, 11 , 1383–1386.

    Blackburn E. H. , 'DNA damage signalling prevents deleterious telomere addition at DNA breaks ' (2009 ) 11 Nat. Cell Biol. : 1383 -1386.

    • Search Google Scholar
  • Codd, V., Mangino, M., van der Harst, P. és mtsai: Common variants near TERC are associated with mean telomere length. Nat. Genet., 2010, 42 , 197–199.

    Harst P. , 'Common variants near TERC are associated with mean telomere length ' (2010 ) 42 Nat. Genet. : 197 -199.

    • Search Google Scholar
  • Ornish, D., Lin, J., Daubenmier J. és mtsai: Increased telomerase activity and comprehensive lifestyle changes: a pilot study. Lancet Oncol., 2008, 9 , 1048–1057.

    Daubenmier J. , 'Increased telomerase activity and comprehensive lifestyle changes: a pilot study ' (2008 ) 9 Lancet Oncol. : 1048 -1057.

    • Search Google Scholar
  • Ornish, D., Brown S. E., Scherwitz, L. W. és mtsai: Can lifestyle changes reverse coronary atherosclerosis? The Lifestyle Heart Trial. Lancet, 1990, 336 , 129–133.

    Scherwitz L. W. , 'Can lifestyle changes reverse coronary atherosclerosis? The Lifestyle Heart Trial ' (1990 ) 336 Lancet : 129 -133.

    • Search Google Scholar
  • Gould, K. L, Ornish, D., Kirkeeide, R. és mtsai: Improved stenosis geometry by quantitative coronary arteriography after vigorous risk factor modification. Am. J. Cardiol., 1992, 69 , 845–853.

    Kirkeeide R. , 'Improved stenosis geometry by quantitative coronary arteriography after vigorous risk factor modification ' (1992 ) 69 Am. J. Cardiol. : 845 -853.

    • Search Google Scholar
  • Gould, K. L., Ornish, D., Scherwitz, L. és mtsai: Changes in myocardial perfusion abnormalities by positron emission tomography after long-term, intense risk factor modification. JAMA, 1995, 274 , 894–901.

    Scherwitz L. , 'Changes in myocardial perfusion abnormalities by positron emission tomography after long-term, intense risk factor modification ' (1995 ) 274 JAMA : 894 -901.

    • Search Google Scholar
  • Ornish, D., Scherwitz, L. W., Billings, J. H. és mtsai: Intensive lifestyle changes for reversal of coronary heart disease. JAMA, 1998, 280 , 2001–2007.

    Billings J. H. , 'Intensive lifestyle changes for reversal of coronary heart disease ' (1998 ) 280 JAMA : 2001 -2007.

    • Search Google Scholar
  • Ornish, D.: Avoiding revascularization with lifestyle changes: The Multicenter Lifestyle Demonstration Project. Am. J. Cardiol., 1998, 82 , 72T–76T.

    Ornish D. , 'Avoiding revascularization with lifestyle changes: The Multicenter Lifestyle Demonstration Project ' (1998 ) 82 Am. J. Cardiol. : 72T -76T.

    • Search Google Scholar
  • Frattaroli, J., Weidner, G., Merritt-Worden, T. A. és mtsai: Angina pectoris and atherosclerotic risk factors in the multisite cardiac lifestyle intervention program. Am. J. Cardiol., 2008, 101 , 911–918.

    Merritt-Worden T. A. , 'Angina pectoris and atherosclerotic risk factors in the multisite cardiac lifestyle intervention program ' (2008 ) 101 Am. J. Cardiol. : 911 -918.

    • Search Google Scholar
  • Aldana, S. G., Greenlaw, R., Salberg, A. és mtsai: The effects of an intensive lifestyle modification program on carotid artery intima-media thickness: a randomized trial. Am. J. Health Promot., 2007, 21 , 510–516.

    Salberg A. , 'The effects of an intensive lifestyle modification program on carotid artery intima-media thickness: a randomized trial ' (2007 ) 21 Am. J. Health Promot. : 510 -516.

    • Search Google Scholar
  • Ornish, D., Weinder, G., Fair, W. R. és mtsai: Intensive lifestyle changes may affect the progression of prostate cancer. J. Urol., 2005, 174 , 1065–1069.

    Fair W. R. , 'Intensive lifestyle changes may affect the progression of prostate cancer ' (2005 ) 174 J. Urol. : 1065 -1069.

    • Search Google Scholar
  • Ornish, D., Magbanua, M. J., Weidner, G. és mtsai: Changes in prostate gene expression in men undergoing an intensive nutrition and lifestyle intervention. Proc. Natl. Acad. Sci. U S A, 2008, 105 , 8369–8374.

    Weidner G. , 'Changes in prostate gene expression in men undergoing an intensive nutrition and lifestyle intervention ' (2008 ) 105 Proc. Natl. Acad. Sci. U S A : 8369 -8374.

    • Search Google Scholar
  • Frattaroli, J., Weidner, G., Dnistrian, A. M. és mtsai: Clinical events in prostate cancer lifestyle trial: results from two years of follow-up. Urology, 2008, 72 , 1319–1323.

    Dnistrian A. M. , 'Clinical events in prostate cancer lifestyle trial: results from two years of follow-up ' (2008 ) 72 Urology : 1319 -1323.

    • Search Google Scholar
  • Liu, S., Stumpfer, M., Hu, F. és mtsai: Whole-grain consumption and risk of coronary heart disease: Results from the Nurses’ Health Study. Am. J. Clin. Nutr., 1999, 70 , 412–419.

    Hu F. , 'Whole-grain consumption and risk of coronary heart disease: Results from the Nurses’ Health Study ' (1999 ) 70 Am. J. Clin. Nutr. : 412 -419.

    • Search Google Scholar
  • Epel, E. S., Blackburn, E. H., Lin, J. és mtsai: Accelerated telomere shortening in response to life stress. PNAS, 2004, 101 , 17312–17315.

    Lin J. , 'Accelerated telomere shortening in response to life stress ' (2004 ) 101 PNAS : 17312 -17315.

    • Search Google Scholar
  • Damjanovic, A. K., Yang, Y., Glaser, R. és mtsai: Accelerated telomere erosion is associated with a declining immune function of caregivers of Alzheimer’s disease patients. J. Immunology, 2007, 179 , 4249–4254.

    Glaser R. , 'Accelerated telomere erosion is associated with a declining immune function of caregivers of Alzheimer’s disease patients ' (2007 ) 179 J. Immunology : 4249 -4254.

    • Search Google Scholar
  • Stauder A.: Közösségi alapú magatartásorvoslási programok. Az esélyerősítés hatékony módszerei. In: Magyar Lelkiállapot 2008. Szerk.: Kopp M. Semmelweis Kiadó, Budapest, 2008, 105–113.

    Stauder A. , '', in Magyar Lelkiállapot 2008 , (2008 ) -.

  • Antoni, M. H., Cruess, D. G., Klimas, N. és mtsai: Stress management and immune system reconstitution in symptomatic HIV-infected gay men over time: Effects on transitional naive T cells (CD4 + CD45RA + CD29 + ). Am. J. Psychiatry, 2002, 159 , 143–145.

    Klimas N. , 'Stress management and immune system reconstitution in symptomatic HIV-infected gay men over time: Effects on transitional naive T cells (CD4+CD45RA+CD29+) ' (2002 ) 159 Am. J. Psychiatry : 143 -145.

    • Search Google Scholar
  • Williams, V. P., Williams, R. B.: LifeSkills: Eight simple ways to build stronger relationships, communicate more clearly and improve your health. New York: Times Books/Random House, 1997.

    Williams R. B. , '', in LifeSkills: Eight simple ways to build stronger relationships, communicate more clearly and improve your health , (1997 ) -.

    • Search Google Scholar
  • Bishop, G. D., Kaur, M. és mtsai: Effects of a psychosocial skills training workshop on psychophysiological and psychosocial risk in patients undergoing coronary artery bypass grafting. American Heart Journal, 2005, 150 , 602–609.

    Kaur M. , 'Effects of a psychosocial skills training workshop on psychophysiological and psychosocial risk in patients undergoing coronary artery bypass grafting ' (2005 ) 150 American Heart Journal : 602 -609.

    • Search Google Scholar
  • Stauder, A., Konkoly Thege, B. és mtsai: Worldwide stress: different problems, similar solutions? Cultural adaptation and evaluation of a standardized stress management program in Hungary. Int. J. Behav. Med., 2010, 17 , 25–32.

    Konkoly Thege B. , 'Worldwide stress: different problems, similar solutions? Cultural adaptation and evaluation of a standardized stress management program in Hungary ' (2010 ) 17 Int. J. Behav. Med. : 25 -32.

    • Search Google Scholar
  • Weidner, G., Kopp, M. S., Kristensen, M. (Eds): Heart disease: envioronment, stress and gender. NATO Science Series, Life and behavioural Sciences. IOS Press, 2000.