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  • 1 Semmelweis Egyetem, Általános Orvostudományi Kar Kardiológiai Központ Budapest Városmajor u. 68. 1122
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A koszorúér-betegség alapját jelentő atheroscleroticus folyamatok gyógyszeres kezelése mellett a percutan intervenciós módszer szerepe az utóbbi évtizedekben egyre jelentősebb. A stentek elterjedésével a percutan koszorúér-intervenció akut sikerrátája jelentős javulást mutatott, azonban a hagyományos fémstentekben keletkezett instentrestenosis újabb kihívást (és anyagi ráfordítást) jelent az intervenciós kardiológia számára. Az instentrestenosis csökkentése hatékonyan kivitelezhető gyógyszerkibocsátó stentek alkalmazásával, ahol a stent fémvázára felvitt polimerhez citosztatikus anyag kapcsolódik. Az intimaproliferáció gátlásával az instentrestenosis gyakorisága 10% alá csökkenthető. A gyógyszerkibocsátó stentekben megjelenő restenosis kezelése azonban jelenleg megoldatlan probléma. Egyes elméletek szerint az érfal reaktivitását kiváltó/fenntartó fém, illetve polimer kiküszöbölése jelenthet megoldást. A kutatások két irányba folytatódnak ezek alapján: 1. biológiailag lebomló polimer, illetve stent; 2. gyógyszerkibocsátó ballon. Jelen dolgozatukban a szerzők egy tanulságos eset kapcsán adnak áttekintést az utóbbi módszerről. Orv. Hetil., 2010, 37, 1509–1514.

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