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  • 1 Semmelweis Egyetem, Általános Orvostudományi Kar II. Belgyógyászati Klinika Budapest Szentkirályi u. 46. 1088
  • 2 Magyar Tudományos Akadémia–Semmelweis Egyetem Molekuláris Medicina Kutatócsoport Budapest
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A hasnyálmirigyrák ugyan ritka betegség, jelentős halálozási aránya miatt azonban a daganatos eredetű halálozás gyakori oka. Hatékony szűrőmódszer nem áll rendelkezésre. A hasnyálmirigyrák döntően az idős emberek betegsége, előfordulása gyakoribb férfiakban, mint nőkben. A daganat gyakorisága változó a különböző országokban, ami a környezeti tényezők fontosságát sejteti a betegség kialakulásának hátterében. A dohányzás a betegség ismert kockázati tényezője, az étrendi tényezők szerepe kisebb jelentőségű. A rák kialakulásának esélyét fokozza továbbá az idült hasnyálmirigy-gyulladás és az elhízás. A cukorbetegség szerepe nem egyértelmű. Számos öröklött csírasejt-mutációt hoztak összefüggésbe a hasnyálmirigyrák kialakulásával. A legnagyobb kockázatot a herediter pancreatitis fennállása jelenti, míg a BRCA2 gén eltérései a leggyakoribbak. Úgy tűnik, hogy a genetikai polimorfizmus szerepe a betegség kialakulásában igen jelentős. Orv. Hetil., 2010, 44, 1816–1822.

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