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  • 1 Semmelweis Egyetem, Általános Orvostudományi Kar Budapest
  • 2 Semmelweis Egyetem, Általános Orvostudományi Kar II. Belgyógyászati Klinika Budapest Szentkirályi u. 46. 1088
Open access

A hepatitis C-vírus-fertőzés világszerte gyakori megbetegedés, amely májzsírosodás, cirrhosis és májrák kialakulásához vezet. Idült hepatitis C-vírus-fertőzöttek mintegy 55%-ában mutatható ki a máj változó mértékű elzsírosodása, amelynek hátterében részben anyagcsere- (metabolikus), részben víruseredetű tényezők állnak. A vírus magfehérjéje számos sejten belüli jelátviteli utat befolyásol. A folyamatok pontos megértése jelenleg is kutatások tárgya. Az elhízás és az inzulinrezisztencia a vírusellenes kezelésre adott választ rontja. A közlemény célja a steatosis hepatis, valamint az inzulinrezisztencia és a kombinált antivirális terápiára adott válasz közötti összefüggés áttekintése idült C-vírus hepatitisben. Orv. Hetil., 2011, 152, 1513–1519.

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