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  • 1 Semmelweis Egyetem, Gyógyszerésztudományi Kar Farmakognóziai Intézet Budapest Üllői út 26. 1085
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A kannabidiol kannabinoid- és szerotoninreceptor-antagonista, de a rimonabantra jellemző depresszív, illetve csökkent inzulinérzékenység mellékhatásoktól mentesen mérsékelheti a hiperfágiát. Emellett, mint a peroxiszómaproliferátor-aktivált receptor-gamma-agonisták, segítheti az adipocyták differenciálódását. A kannabidiol immunmoduláns hatása miatt mérsékelheti a magas glükózszint indukálta atherosclerosis progresszióját. A metabolikus szindróma legveszélyesebb szövődményével, az elzáródásos kórképekkel szemben is hatásos. A kannabidiol gyenge receptorkötődése révén csak az adjuváns terápia része lehet. A citokróm P450 enzimrendszert gátló hatása szintén óvatosságra int, azonban a kannabidiol kiegészítő alkalmazása gyenge mellékhatásprofilja miatt hasznossá válhat. Orv. Hetil., 2012, 153, 499–504.

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