Orvosi Hetilap
Volume/Issue:
Volume 153: Issue 48
Adenovirus infections in immuncompromised patients
Authors: Balázs Stercz 1 , Károly Nagy 1 , and József Ongrádi 1
View More View Less
  • 1 Semmelweis Egyetem, Általános Orvostudományi Kar Orvosi Mikrobiológiai Intézet Budapest Nagyvárad tér 4. 1089
DOI:
https://doi.org/10.1556/oh.2012.29496
Page Count:
1896–1904
Publication Date:
01 Dec 2012
Online Publication Date:
25 Nov 2012
Article Category:
Research Article
Open access

Az emberi adenovírusok modellként szolgálnak genetikai kutatásokban és génterápiában. Az általuk immunkompetens egyénekben okozott légúti, gyomor-bél rendszeri és szemfertőzések többnyire szövődménymentes lefolyásúak. Lappangó állapotukból azonban reaktiválódhatnak és akár halálos opportunista fertőzéseket okozhatnak immunszuppresszált egyénekben. Az immunszuppresszió okától függően különféle szerotípusú adenovírusok egyedül vagy kombinációkban eltérő szerveket betegíthetnek meg. Súlyos kombinált immundeficientiában szenvedő gyermekekben tüdő- és májgyulladást, vérzéses hólyaghurutot okozhatnak az A- és C-species szerotípusai. A szerzett immunhiányos állapotok közül gyermekkori haemapoeticus őssejt átültetését követő légúti, bélrendszeri és húgyúti gyulladásokban a 31-es típus gyakori. Szervátültetést követően a B-species szerotípusai okozhatják az átültetett szerv pusztulását. AIDS során az F-speciesbe sorolt új szerotípusok, valamint a D-species tagjai okoznak bélgyulladást, a B-species rekombináns szerotípusai pedig húgyúti fertőzéseket. Lymphomák, daganatok, szisztémás lupus erythematosus rosszabbodását adenovírusok okozta immunszuppresszió elősegítheti. Az opportunista adenovírusok diagnosztikájában a szerológiai eljárások nem megbízhatóak, a vírus-DNS, illetve a kópiaszám nyomon követése célszerű. Kezelésre cidofovirszármazékok, ribavirin, ganciclovir, vidarabin, mikro-RNS alkalmas. Orv. Hetil., 2012, 153, 1896–1904.

If the inline PDF is not rendering correctly, you can download the PDF file here.

  • Liu, E. B., Ferreyra, L., Fischer, S. L., et al.: Genetic analysis of a novel human adenovirus with a serologically unique hexon and a recombinant fiber gene. PLoS One, 2011, 6, e24491.

    Fischer S. L. , 'Genetic analysis of a novel human adenovirus with a serologically unique hexon and a recombinant fiber gene ' (2011 ) 6 PLoS One : e24491 -.

    • Search Google Scholar

  • Kojaoghlanian, T., Flomenberg, P., Horwitz, M. S.: The impact of adenovirus infection on the immunocompromised host. Rev. Med. Virol., 2003, 13, 155–171.

    Horwitz M. S. , 'The impact of adenovirus infection on the immunocompromised host ' (2003 ) 13 Rev. Med. Virol. : 155 -171.

    • Search Google Scholar

  • Gregory, S. M., Nazir, S. A., Metcalf, J. P.: Implications of the innate immune response to adenovirus and adenoviral vectors. Future Virol., 2011, 6, 357–374.

    Metcalf J. P. , 'Implications of the innate immune response to adenovirus and adenoviral vectors ' (2011 ) 6 Future Virol. : 357 -374.

    • Search Google Scholar

  • Leen, A. M., Rooney, C. M.: Adenovirus as an emerging pathogen in immunocompromised patients. Br. J. Haematol., 2005, 128, 135–144.

    Rooney C. M. , 'Adenovirus as an emerging pathogen in immunocompromised patients ' (2005 ) 128 Br. J. Haematol. : 135 -144.

    • Search Google Scholar

  • Zhao, H., Dahlö, M., Isaksson, A., et al.: The transcriptome of the adenovirus infected cell. Virology, 2012, 424, 115–128.

    Isaksson A. , 'The transcriptome of the adenovirus infected cell ' (2012 ) 424 Virology : 115 -128.

    • Search Google Scholar

  • Garnett, C. T., Talekar, G., Mahr, J. A., et al.: Latent species C adenoviruses in human tonsil tissues. J. Virol., 2009, 83, 2417–2428.

    Mahr J. A. , 'Latent species C adenoviruses in human tonsil tissues ' (2009 ) 83 J. Virol. : 2417 -2428.

    • Search Google Scholar

  • Ongrádi, J., Telekes, A., Farkas, J., et al.: The effect of prostaglandins on the replication of adenovirus wild types and temperature-sensitive mutants. Acta Microbiol. Immunol. Hung., 1994, 41, 173–188.

    Farkas J. , 'The effect of prostaglandins on the replication of adenovirus wild types and temperature-sensitive mutants ' (1994 ) 41 Acta Microbiol. Immunol. Hung. : 173 -188.

    • Search Google Scholar

  • Ongrádi, J., Kulcsár, G., Dán, P., et al.: Activation of adenovirus type 5 latent infections of tissue culture. Intervirology, 1980, 14, 310–315.

    Dán P. , 'Activation of adenovirus type 5 latent infections of tissue culture ' (1980 ) 14 Intervirology : 310 -315.

    • Search Google Scholar

  • Heim, A.: Advances in the management of disseminated adenovirus disease in stem cell transplant recipients: impact of adenovirus load (DNAemia) testing. Expert Rev. Anti Infect. Ther., 2011, 9, 943–945.

    Heim A. , 'Advances in the management of disseminated adenovirus disease in stem cell transplant recipients: impact of adenovirus load (DNAemia) testing ' (2011 ) 9 Expert Rev. Anti Infect. Ther. : 943 -945.

    • Search Google Scholar

  • Raper, S. E., Chirmule, N., Lee, F. S., et al.: Fatal systemic inflammatory response syndrome in a ornithine transcarbamylase deficient patient following adenoviral gene transfer. Mol. Genet. Metab., 2003, 80, 148–158.

    Lee F. S. , 'Fatal systemic inflammatory response syndrome in a ornithine transcarbamylase deficient patient following adenoviral gene transfer ' (2003 ) 80 Mol. Genet. Metab. : 148 -158.

    • Search Google Scholar

  • Fischer, S. A.: Emerging viruses in transplantation: there is more to infection after transplant than CMV and EBV. Transplantation, 2008, 86, 1327–1339.

    Fischer S. A. , 'Emerging viruses in transplantation: there is more to infection after transplant than CMV and EBV ' (2008 ) 86 Transplantation : 1327 -1339.

    • Search Google Scholar

  • Ongrádi, J.: Identification of a feline adenovirus isolate that replicates in monkey and human cells in vitro. Am. J. Vet. Res., 1999, 60, 1463.

    Ongrádi J. , 'Identification of a feline adenovirus isolate that replicates in monkey and human cells in vitro ' (1999 ) 60 Am. J. Vet. Res. : 1463 -.

    • Search Google Scholar

  • Phan, T. G., Shimizu, H., Nishimura, S., et al.: Human adenovirus type 1 related to feline adenovirus: evidence of interspecies transmission. Clin. Lab., 2006, 52, 515–518.

    Nishimura S. , 'Human adenovirus type 1 related to feline adenovirus: evidence of interspecies transmission ' (2006 ) 52 Clin. Lab. : 515 -518.

    • Search Google Scholar

  • Pham, T. T., Burchette, J. L. Jr., Hale, L. P.: Fatal disseminated adenovirus infections in immunocompromised patients. Am. J. Clin. Pathol., 2003, 120, 575–583.

    Hale L. P. , 'Fatal disseminated adenovirus infections in immunocompromised patients ' (2003 ) 120 Am. J. Clin. Pathol. : 575 -583.

    • Search Google Scholar

  • Hierholzer, J. C.: Adenoviruses in the immunocompromised host. Clin. Microbiol. Rev., 1992, 5, 262–274.

    Hierholzer J. C. , 'Adenoviruses in the immunocompromised host ' (1992 ) 5 Clin. Microbiol. Rev. : 262 -274.

    • Search Google Scholar

  • Ongrádi, J., Sallay, K., Kulcsár, G.: The decreased antibacterial activity of oral polymorphonuclear leukocytes coincides with the occurrence of virus-carrying oral lymphocytes and epithelial cells. Folia Microbiol. (Praha), 1987, 32, 438–447.

    Kulcsár G. , 'The decreased antibacterial activity of oral polymorphonuclear leukocytes coincides with the occurrence of virus-carrying oral lymphocytes and epithelial cells ' (1987 ) 32 Folia Microbiol. (Praha) : 438 -447.

    • Search Google Scholar

  • Ongrádi, J., Farkas, J., Kulcsár, G., et al.: Suppressed phagocytosis but promoted bacterial growth upon the effect of virus free supernatants of infected lymphocytes. Acta Microbiol. Immunol. Hung., 1994, 41, 51–72.

    Kulcsár G. , 'Suppressed phagocytosis but promoted bacterial growth upon the effect of virus free supernatants of infected lymphocytes ' (1994 ) 41 Acta Microbiol. Immunol. Hung. : 51 -72.

    • Search Google Scholar

  • Echavarria, M.: Adenoviruses in immunocompromised hosts. Clin. Microbiol. Rev., 2008, 21, 704–715.

    Echavarria M. , 'Adenoviruses in immunocompromised hosts ' (2008 ) 21 Clin. Microbiol. Rev. : 704 -715.

    • Search Google Scholar

  • Crooks, B. N., Taylor, C. E., Turner, A. J., et al.: Respiratory viral infections in primary immune deficiencies: significance and relevance to clinical outcome in a single BMT unit. Bone Marrow Transplant., 2000, 26, 1097–1102.

    Turner A. J. , 'Respiratory viral infections in primary immune deficiencies: significance and relevance to clinical outcome in a single BMT unit ' (2000 ) 26 Bone Marrow Transplant. : 1097 -1102.

    • Search Google Scholar

  • Tuvia, J., Weisselberg, B., Shif, I., et al.: Aplastic anaemia complicating adenovirus infection in DiGeorge syndrome. Eur. J. Pediatr., 1988, 147, 643–644.

    Shif I. , 'Aplastic anaemia complicating adenovirus infection in DiGeorge syndrome ' (1988 ) 147 Eur. J. Pediatr. : 643 -644.

    • Search Google Scholar

  • Siegal, F. P., Dikman, S. H., Arayata, R. B., et al.: Fatal disseminated adenovirus 11 pneumonia in an agammaglobulinemic patient. Am. J. Med., 1981, 71, 1062–1067.

    Arayata R. B. , 'Fatal disseminated adenovirus 11 pneumonia in an agammaglobulinemic patient ' (1981 ) 71 Am. J. Med. : 1062 -1067.

    • Search Google Scholar

  • Winkelstein, J. A., Marino, M. C., Lederman, H. M., et al.: X-linked agammaglobulinemia: report on a United States registry of 201 patients. Medicine (Baltimore), 2006, 85, 193–202.

    Lederman H. M. , 'X-linked agammaglobulinemia: report on a United States registry of 201 patients ' (2006 ) 85 Medicine (Baltimore) : 193 -202.

    • Search Google Scholar

  • Van den Veyver, I. B., Ni, J., Bowles, N., et al.: Detection of intrauterine viral infection using the polymerase chain reaction. Mol. Genet. Metab., 1998, 63, 85–95.

    Bowles N. , 'Detection of intrauterine viral infection using the polymerase chain reaction ' (1998 ) 63 Mol. Genet. Metab. : 85 -95.

    • Search Google Scholar

  • Flomenberg, P., Babbitt, J., Drobyski, W. R., et al.: Increasing incidence of adenovirus disease in bone marrow transplant recipients. J. Infect. Dis., 1994, 169, 775–781.

    Drobyski W. R. , 'Increasing incidence of adenovirus disease in bone marrow transplant recipients ' (1994 ) 169 J. Infect. Dis. : 775 -781.

    • Search Google Scholar

  • Leruez-Ville, M., Chardin-Ouachée, M., Neven, B., et al.: Description of an adenovirus A31 outbreak in a paediatric haematology unit. Bone Marrow Transplant., 2006, 38, 23–28.

    Neven B. , 'Description of an adenovirus A31 outbreak in a paediatric haematology unit ' (2006 ) 38 Bone Marrow Transplant. : 23 -28.

    • Search Google Scholar

  • Kroes, A. C., de Klerk, E. P., Lankester, A. C., et al.: Sequential emergence of multiple adenovirus serotypes after pediatric stem cell transplantation. J. Clin. Virol., 2007, 38, 341–347.

    Lankester A. C. , 'Sequential emergence of multiple adenovirus serotypes after pediatric stem cell transplantation ' (2007 ) 38 J. Clin. Virol. : 341 -347.

    • Search Google Scholar

  • Lion, T., Baumgartinger, R., Watzinger, F., et al.: Molecular monitoring of adenovirus in peripheral blood after allogeneic bone marrow transplantation permits early diagnosis of disseminated disease. Blood, 2003, 102, 1114–1120.

    Watzinger F. , 'Molecular monitoring of adenovirus in peripheral blood after allogeneic bone marrow transplantation permits early diagnosis of disseminated disease ' (2003 ) 102 Blood : 1114 -1120.

    • Search Google Scholar

  • Schilham, M. W., Claas, E. C., van Zaane, W., et al.: High levels of adenovirus DNA in serum correlate with fatal outcome of adenovirus infection in children after allogeneic stem-cell transplantation. Clin. Infect. Dis., 2002, 35, 526–532.

    Zaane W. , 'High levels of adenovirus DNA in serum correlate with fatal outcome of adenovirus infection in children after allogeneic stem-cell transplantation ' (2002 ) 35 Clin. Infect. Dis. : 526 -532.

    • Search Google Scholar

  • Ison, M. G., Green, M.: Adenovirus in solid organ transplant recipients. Am. J. Transplant., 2009, 9, (Suppl. 4), S161–S165.

    Green M. , 'Adenovirus in solid organ transplant recipients ' (2009 ) 9 Am. J. Transplant. : (Suppl. 4), S161 -S165.

    • Search Google Scholar

  • Varma, M. C., Kushner, Y. B., Ko, D. S., et al.: Early onset adenovirus infection after simultaneous kidney-pancreas transplant. Am. J. Transplant., 2011, 11, 623–627.

    Ko D. S. , 'Early onset adenovirus infection after simultaneous kidney-pancreas transplant ' (2011 ) 11 Am. J. Transplant. : 623 -627.

    • Search Google Scholar

  • Shirali, G. S., Ni, J., Chinnock, R. E., et al.: Association of viral genome with graft loss in children after cardiac transplantation. N. Engl. J. Med., 2001, 344, 1498–1503.

    Chinnock R. E. , 'Association of viral genome with graft loss in children after cardiac transplantation ' (2001 ) 344 N. Engl. J. Med. : 1498 -1503.

    • Search Google Scholar

  • Avery, R. K.: Viral triggers of cardiac-allograft dysfunction. N. Engl. J. Med., 2001, 344, 1545–1547.

    Avery R. K. , 'Viral triggers of cardiac-allograft dysfunction ' (2001 ) 344 N. Engl. J. Med. : 1545 -1547.

    • Search Google Scholar

  • Varki, N. M., Bhuta, S., Drake, T., et al.: Adenovirus hepatitis in two successive liver transplants in a child. Arch. Pathol. Lab. Med., 1990, 114, 106–109.

    Drake T. , 'Adenovirus hepatitis in two successive liver transplants in a child ' (1990 ) 114 Arch. Pathol. Lab. Med. : 106 -109.

    • Search Google Scholar

  • Lecatsas, G., van Wyk, J. A.: DNA viruses in urine after renal transplantation. S. Afr. Med. J., 1978, 53, 787–788.

    Wyk J. A. , 'DNA viruses in urine after renal transplantation ' (1978 ) 53 S. Afr. Med. J. : 787 -788.

    • Search Google Scholar

  • Sujeet, K., Vasudev, B., Desai, P., et al.: Acute kidney injury requiring dialysis secondary to adenovirus nephritis in renal transplant recipient. Transpl. Infect. Dis., 2011, 13, 174–177.

    Desai P. , 'Acute kidney injury requiring dialysis secondary to adenovirus nephritis in renal transplant recipient ' (2011 ) 13 Transpl. Infect. Dis. : 174 -177.

    • Search Google Scholar

  • Harnett, G. B., Bucens, M. R., Clay, S. J., et al.: Acute haemorrhagic cystitis caused by adenovirus type 11 in a recipient of a transplanted kidney. Med. J. Aust., 1982, 1, 565–567.

    Clay S. J. , 'Acute haemorrhagic cystitis caused by adenovirus type 11 in a recipient of a transplanted kidney ' (1982 ) 1 Med. J. Aust. : 565 -567.

    • Search Google Scholar

  • Watcharananan, S. P., Avery, R., Ingsathit, A., et al.: Adenovirus disease after kidney transplantation: course of infection and outcome in relation to blood viral load and immune recovery. Am. J. Transplant., 2011, 11, 1308–1314.

    Ingsathit A. , 'Adenovirus disease after kidney transplantation: course of infection and outcome in relation to blood viral load and immune recovery ' (2011 ) 11 Am. J. Transplant. : 1308 -1314.

    • Search Google Scholar

  • Ardehali, H., Volmar, K., Roberts, C., et al.: Fatal disseminated adenoviral infection in a renal transplant patient. Transplantation, 2001, 71, 998–999.

    Roberts C. , 'Fatal disseminated adenoviral infection in a renal transplant patient ' (2001 ) 71 Transplantation : 998 -999.

    • Search Google Scholar

  • Hofland, C. A., Eron, L. J., Washecka, R. M.: Hemorrhagic adenovirus cystitis after renal transplantation. Transplant. Proc., 2004, 36, 3025–3027.

    Washecka R. M. , 'Hemorrhagic adenovirus cystitis after renal transplantation ' (2004 ) 36 Transplant. Proc. : 3025 -3027.

    • Search Google Scholar

  • Matar, L. D., McAdams, H. P., Palmer, S. M., et al.: Respiratory viral infections in lung transplant recipients: radiologic findings with clinical correlation. Radiology, 1999, 213, 735–742.

    Palmer S. M. , 'Respiratory viral infections in lung transplant recipients: radiologic findings with clinical correlation ' (1999 ) 213 Radiology : 735 -742.

    • Search Google Scholar

  • Doan, M. L., Mallory, G. B., Kaplan, S. L., et al.: Treatment of adenovirus pneumonia with cidofovir in pediatric lung transplant recipients. J. Heart Lung Transplant., 2007, 26, 883–889.

    Kaplan S. L. , 'Treatment of adenovirus pneumonia with cidofovir in pediatric lung transplant recipients ' (2007 ) 26 J. Heart Lung Transplant. : 883 -889.

    • Search Google Scholar

  • Ziring, D., Tran, R., Edelstein, S., et al.: Infectious enteritis after intestinal transplantation: incidence, timing, and outcome. Transplantation, 2005, 79, 702–709.

    Edelstein S. , 'Infectious enteritis after intestinal transplantation: incidence, timing, and outcome ' (2005 ) 79 Transplantation : 702 -709.

    • Search Google Scholar

  • Florescu, D. F., Islam, M. K., Mercer, D. F., et al.: Adenovirus infections in pediatric small bowel transplant recipients. Transplantation, 2010, 90, 198–204.

    Mercer D. F. , 'Adenovirus infections in pediatric small bowel transplant recipients ' (2010 ) 90 Transplantation : 198 -204.

    • Search Google Scholar

  • Khoo, S. H., Bailey, A. S., de Jong, J. C., et al.: Adenovirus infections in human immunodeficiency virus-positive patients: clinical features and molecular epidemiology. J. Infect. Dis., 1995, 172, 629–637.

    Jong J. C. , 'Adenovirus infections in human immunodeficiency virus-positive patients: clinical features and molecular epidemiology ' (1995 ) 172 J. Infect. Dis. : 629 -637.

    • Search Google Scholar

  • De Jong, J. C., Wermenbol, A. G., Verweij-Uijterwaal, M. W., et al.: Adenoviruses from human immunodeficiency virus-infected individuals, including two strains that represent new candidate serotypes Ad50 and Ad51 of species B1 and D, respectively. J. Clin. Microbiol., 1999, 37, 3940–3945.

    Verweij-Uijterwaal M. W. , 'Adenoviruses from human immunodeficiency virus-infected individuals, including two strains that represent new candidate serotypes Ad50 and Ad51 of species B1 and D, respectively ' (1999 ) 37 J. Clin. Microbiol. : 3940 -3945.

    • Search Google Scholar

  • Kliewer, S., Garcia, J., Pearson, L., et al.: Multiple transcriptional regulatory domains in the human immunodeficiency virus type 1 long terminal repeat are involved in basal and E1A/E1B-induced promoter activity. J. Virol., 1989, 63, 4616–4625.

    Pearson L. , 'Multiple transcriptional regulatory domains in the human immunodeficiency virus type 1 long terminal repeat are involved in basal and E1A/E1B-induced promoter activity ' (1989 ) 63 J. Virol. : 4616 -4625.

    • Search Google Scholar

  • Hierholzer, J. C., Wigand, R., Anderson, L. J., et al.: Adenoviruses from patients with AIDS: a plethora of serotypes and a description of five new serotypes of subgenus D (types 43-47). J. Infect. Dis., 1988, 158, 804–813.

    Anderson L. J. , 'Adenoviruses from patients with AIDS: a plethora of serotypes and a description of five new serotypes of subgenus D (types 43-47) ' (1988 ) 158 J. Infect. Dis. : 804 -813.

    • Search Google Scholar

  • Ongrádi, J., Csata, S., Farkas, J., et al.: Transfected lymphocyte extracts of patients with urological tumours: complement temperature-sensitive adenovirus mutants in vitro. Int. Urol. Nephrol., 1994, 26, 361–373.

    Farkas J. , 'Transfected lymphocyte extracts of patients with urological tumours: complement temperature-sensitive adenovirus mutants in vitro ' (1994 ) 26 Int. Urol. Nephrol. : 361 -373.

    • Search Google Scholar

  • Kajon, A. E., Dickson, L. M., Fisher, B. T., et al.: Fatal disseminated adenovirus infection in a young adult with systemic lupus erythematosus. J. Clin. Virol., 2011, 50, 80–83.

    Fisher B. T. , 'Fatal disseminated adenovirus infection in a young adult with systemic lupus erythematosus ' (2011 ) 50 J. Clin. Virol. : 80 -83.

    • Search Google Scholar

  • Perl, A., Fernandez, D., Telarico, T., et al.: Endogenous retroviral pathogenesis in lupus. Curr. Opin. Rheumatol., 2010, 22, 483–492.

    Telarico T. , 'Endogenous retroviral pathogenesis in lupus ' (2010 ) 22 Curr. Opin. Rheumatol. : 483 -492.

    • Search Google Scholar

  • Howard, D. S., Phillips, I. G., Reece, D. E., et al.: Adenovirus infections in hematopoietic stem cell transplant recipients. Clin. Infect. Dis., 1999, 29, 1494–1501.

    Reece D. E. , 'Adenovirus infections in hematopoietic stem cell transplant recipients ' (1999 ) 29 Clin. Infect. Dis. : 1494 -1501.

    • Search Google Scholar

  • Adeyemi, O. A., Yeldandi, A. V., Ison, M. G.: Fatal adenovirus pneumonia in a person with AIDS and Burkitt lymphoma: a case report and review of the literature. AIDS Read., 2008, 18, 196–198, 201–202, 206–207.

    Ison M. G. , 'Fatal adenovirus pneumonia in a person with AIDS and Burkitt lymphoma: a case report and review of the literature ' (2008 ) 18 AIDS Read. : 196 -198, 201–202, 206–207.

    • Search Google Scholar

  • Echavarria, M., Sanchez, J. L., Kolavic-Gray, S. A., et al.: Rapid detection of adenovirus in throat swab specimens by PCR during respiratory disease outbreaks among military recruits. J. Clin. Microbiol., 2003, 41, 810–812.

    Kolavic-Gray S. A. , 'Rapid detection of adenovirus in throat swab specimens by PCR during respiratory disease outbreaks among military recruits ' (2003 ) 41 J. Clin. Microbiol. : 810 -812.

    • Search Google Scholar

  • Allard, A., Girones, R., Juto, P., et al.: Polymerase chain reaction for detection of adenoviruses in stool samples. J. Clin. Microbiol., 1990, 28, 2659–2667.

    Juto P. , 'Polymerase chain reaction for detection of adenoviruses in stool samples ' (1990 ) 28 J. Clin. Microbiol. : 2659 -2667.

    • Search Google Scholar

  • Sester, M., Sester, U., Alarcon Salvador, S., et al.: Age-related decrease in adenovirus-specific T cell responses. J. Infect. Dis., 2002, 185, 1379–1387.

    Alarcon Salvador S. , 'Age-related decrease in adenovirus-specific T cell responses ' (2002 ) 185 J. Infect. Dis. : 1379 -1387.

    • Search Google Scholar

  • Neofytos, D., Ojha, A., Mookerjee, B., et al.: Treatment of adenovirus disease in stem cell transplant recipients with cidofovir. Biol. Blood Marrow Transplant., 2007, 13, 74–81.

    Mookerjee B. , 'Treatment of adenovirus disease in stem cell transplant recipients with cidofovir ' (2007 ) 13 Biol. Blood Marrow Transplant. : 74 -81.

    • Search Google Scholar

  • Muller, R., Ditzen, A., Hille, K., et al.: Detection of herpesvirus and adenovirus co-infections with diagnostic DNA-microarrays. J. Virol. Methods, 2009, 155, 161–166.

    Hille K. , 'Detection of herpesvirus and adenovirus co-infections with diagnostic DNA-microarrays ' (2009 ) 155 J. Virol. Methods : 161 -166.

    • Search Google Scholar

  • Guérin-El Khourouj, V., Dalle, J. H., Pedron, B., et al.: Quantitative and qualitative CD4 T cell immune responses related to adenovirus DNAemia in hematopoietic stem cell transplantation. Biol. Blood Marrow Transplant., 2011, 17, 476–485.

    Pedron B. , 'Quantitative and qualitative CD4 T cell immune responses related to adenovirus DNAemia in hematopoietic stem cell transplantation ' (2011 ) 17 Biol. Blood Marrow Transplant. : 476 -485.

    • Search Google Scholar

  • Hoffman, J. A., Shah, A. J., Ross, L. A., et al.: Adenoviral infections and a prospective trial of cidofovir in pediatric hematopoietic stem cell transplantation. Biol. Blood Marrow Transplant., 2001, 7, 388–394.

    Ross L. A. , 'Adenoviral infections and a prospective trial of cidofovir in pediatric hematopoietic stem cell transplantation ' (2001 ) 7 Biol. Blood Marrow Transplant. : 388 -394.

    • Search Google Scholar

  • Saquib, R., Melton, L. B., Chandrakantan, A., et al.: Disseminated adenovirus infection in renal transplant recipients: the role of cidofovir and intravenous immunoglobulin. Transpl. Infect. Dis., 2010, 12, 77–83.

    Chandrakantan A. , 'Disseminated adenovirus infection in renal transplant recipients: the role of cidofovir and intravenous immunoglobulin ' (2010 ) 12 Transpl. Infect. Dis. : 77 -83.

    • Search Google Scholar

  • Waye, M. M. Y., Sing, C. W.: Anti-viral drugs for human adenoviruses. Pharmaceuticals, 2010, 3, 3343–3354.

    Sing C. W. , 'Anti-viral drugs for human adenoviruses ' (2010 ) 3 Pharmaceuticals : 3343 -3354.

    • Search Google Scholar

  • Tóth, K., Spencer, J. F., Dhar, D., et al.: Hexadecyloxypropyl-cidofovir, CMX001, prevents adenovirus-induced mortality in a permissive, immunosuppressed animal model. Proc. Natl. Acad. Sci. USA, 2008, 105, 7293–7297.

    Dhar D. , 'Hexadecyloxypropyl-cidofovir, CMX001, prevents adenovirus-induced mortality in a permissive, immunosuppressed animal model ' (2008 ) 105 Proc. Natl. Acad. Sci. USA : 7293 -7297.

    • Search Google Scholar

  • Paolino, K., Sande, J., Perez, E., et al.: Eradication of disseminated adenovirus infection in a pediatric hematopoietic stem cell transplantation recipient using the novel antiviral agent CMX001. J. Clin. Virol., 2011, 50, 167–170.

    Perez E. , 'Eradication of disseminated adenovirus infection in a pediatric hematopoietic stem cell transplantation recipient using the novel antiviral agent CMX001 ' (2011 ) 50 J. Clin. Virol. : 167 -170.

    • Search Google Scholar

  • Florescu, D. F., Pergam, S. A., Neely, M. N., et al.: Safety and efficacy of CMX001 as salvage therapy for severe adenovirus infections in immunocompromised patients. Biol. Blood Marrow Transplant., 2012, 18, 731–738.

    Neely M. N. , 'Safety and efficacy of CMX001 as salvage therapy for severe adenovirus infections in immunocompromised patients ' (2012 ) 18 Biol. Blood Marrow Transplant. : 731 -738.

    • Search Google Scholar

  • Morfin, F., Dupuis-Girod, S., Mundweiler, S., et al.: In vitro susceptibility of adenovirus to antiviral drugs is species-dependent. Antivir. Ther., 2005, 10, 225–229.

    Mundweiler S. , 'In vitro susceptibility of adenovirus to antiviral drugs is species-dependent ' (2005 ) 10 Antivir. Ther. : 225 -229.

    • Search Google Scholar

  • Arav-Boger, R., Echavarria, M., Forman, M., et al.: Clearance of adenoviral hepatitis with ribavirin therapy in a pediatric liver transplant recipient. Pediatr. Infect. Dis. J., 2000, 19, 1097–1100.

    Forman M. , 'Clearance of adenoviral hepatitis with ribavirin therapy in a pediatric liver transplant recipient ' (2000 ) 19 Pediatr. Infect. Dis. J. : 1097 -1100.

    • Search Google Scholar

  • Chakrabarti, S., Collingham, K. E., Fegan, C. D., et al.: Fulminant adenovirus hepatitis following unrelated bone marrow transplantation: failure of intravenous ribavirin therapy. Bone Marrow Transplant., 1999, 23, 1209–1211.

    Fegan C. D. , 'Fulminant adenovirus hepatitis following unrelated bone marrow transplantation: failure of intravenous ribavirin therapy ' (1999 ) 23 Bone Marrow Transplant. : 1209 -1211.

    • Search Google Scholar

  • Bruno, B., Gooley, T., Hackman, R. C., et al.: Adenovirus infection in hematopoietic stem cell transplantation: effect of ganciclovir and impact on survival. Biol. Blood Marrow Transplant., 2003, 9, 341–352.

    Hackman R. C. , 'Adenovirus infection in hematopoietic stem cell transplantation: effect of ganciclovir and impact on survival ' (2003 ) 9 Biol. Blood Marrow Transplant. : 341 -352.

    • Search Google Scholar

  • Kurosaki, K., Miwa, N., Yoshida, Y., et al.: Therapeutic basis of vidarabine on adenovirus-induced haemorrhagic cystitis. Antivir. Chem. Chemother., 2004, 15, 281–285.

    Yoshida Y. , 'Therapeutic basis of vidarabine on adenovirus-induced haemorrhagic cystitis ' (2004 ) 15 Antivir. Chem. Chemother. : 281 -285.

    • Search Google Scholar

  • Kawakami, M., Ueda, S., Maeda, T., et al.: Vidarabine therapy for virus-associated cystitis after allogeneic bone marrow transplantation. Bone Marrow Transplant., 1997, 20, 485–490.

    Maeda T. , 'Vidarabine therapy for virus-associated cystitis after allogeneic bone marrow transplantation ' (1997 ) 20 Bone Marrow Transplant. : 485 -490.

    • Search Google Scholar

  • Bordigoni, P., Carret, A. S., Venard, V., et al.: Treatment of adenovirus infections in patients undergoing allogeneic hematopoietic stem cell transplantation. Clin. Infect. Dis., 2001, 32, 1290–1297.

    Venard V. , 'Treatment of adenovirus infections in patients undergoing allogeneic hematopoietic stem cell transplantation ' (2001 ) 32 Clin. Infect. Dis. : 1290 -1297.

    • Search Google Scholar

  • D’Cruz, O. J., Uckun, F. M.: Stampidine: a selective oculo-genital microbicide. J. Antimicrob. Chemother., 2005, 56, 10–19.

    Uckun F. M. , 'Stampidine: a selective oculo-genital microbicide ' (2005 ) 56 J. Antimicrob. Chemother. : 10 -19.

    • Search Google Scholar

  • Cawood, R., Chen, H. H., Carroll, F., et al.: Use of tissue-specific microRNA to control pathology of wild-type adenovirus without attenuation of its ability to kill cancer cells. PLoS Pathog., 2009, 5, e1000440.

    Carroll F. , 'Use of tissue-specific microRNA to control pathology of wild-type adenovirus without attenuation of its ability to kill cancer cells ' (2009 ) 5 PLoS Pathog. : e1000440 -.

    • Search Google Scholar

  • Pirofski, L. A., Casadevall, A.: Use of licensed vaccines for active immunization of the immunocompromised host. Clin. Microbiol. Rev., 1998, 11, 1–26.

    Casadevall A. , 'Use of licensed vaccines for active immunization of the immunocompromised host ' (1998 ) 11 Clin. Microbiol. Rev. : 1 -26.

    • Search Google Scholar

  • Feuchtinger, T., Lang, P., Hamprecht, K., et al.: Isolation and expansion of human adenovirus-specific CD4+ and CD8+ T cells according to IFN-gamma secretion for adjuvant immunotherapy. Exp. Hematol., 2004, 32, 282–289.

    Hamprecht K. , 'Isolation and expansion of human adenovirus-specific CD4+ and CD8+ T cells according to IFN-gamma secretion for adjuvant immunotherapy ' (2004 ) 32 Exp. Hematol. : 282 -289.

    • Search Google Scholar
Cover Orvosi Hetilap
Orvosi Hetilap
Print ISSN:
0030-6002
Online ISSN:
1788-6120
Keywords:
opportunista fertőzések; haemapoeticus őssejt- és szervtranszplantáció; adenovírus-szerotípusok; molekuláris diagnosztika; antivirális kezelés; opportunistic infections; hematopoietic stem cell and organ transplantation; adenovirus serotypes; molecular diagnostics; antiviral treatment

Monthly Content Usage

Abstract Views Full Text Views PDF Downloads
Aug 2020 0 4 33
Sep 2020 0 5 32
Oct 2020 0 8 46
Nov 2020 0 11 113
Dec 2020 0 2 155
Jan 2021 0 6 363
Feb 2021 0 0 0