Bevezetés: Krónikus vesebetegségben elengedhetetlen a glomerulusfiltrációs ráta ismerete, mivel annak mértéke határozza meg a stádiumokat, és iránymutató a kezelés szempontjából. Célkitűzés: A szerzők két, a standardizált kreatininen, valamint öt immunturbidimetriás cisztatin-C-meghatározáson alapuló becsült glomerulusfiltrációs ráta egyenletét vizsgálták. Módszer: Az analitok és az egyenletek eloszlását, kapcsolataikat, a becsült glomerulusfiltrációs ráták közötti különbségeket és stádiumbesorolásaikat tanulmányozták. Eredmények: A cisztatin-C-képletek több beteget soroltak az 1-es stádiumba, míg a kreatinines képletek a 2-es, 3-as és 4-esbe. Az 5. stádiumba a Grubb1-, Grubb2- és Larsson-képletek több, míg a Tan- és Sjöström-képletek kevesebb beteget soroltak, mint a kreatinines képletek. Legjobban a Grubb1- és Grubb2-egyenletek stádiumbesorolásai hasonlítottak egymásra. A 3–5. stádiumok legritkábban a Sjöström-képlet esetében fordultak elő. Következtetések: A különböző képletekkel számolt becsült glomerulusfiltrációs ráták szignifikánsan befolyásolhatják a stádiumbeosztást, így a betegek kezelését és kilátásaik becslését is. Orv. Hetil., 2013, 154, 415–425.
Andrew, S. L., Josef, C., Ethan, B., et al.: National Kidney Foundation Practice Guidelines for Chronic Kidney Disease: Evaluation, Classification, and Stratification. Ann. Intern. Med., 2003, 139, 137–147.
Ethan B. , 'National Kidney Foundation Practice Guidelines for Chronic Kidney Disease: Evaluation, Classification, and Stratification ' (2003 ) 139 Ann. Intern. Med. : 137 -147 .
Graves, J. W.: Diagnosis and management of chronic kidney disease. Mayo Clin. Proc., 2008, 83, 1064–1069.
Graves J. W. , 'Diagnosis and management of chronic kidney disease ' (2008 ) 83 Mayo Clin. Proc. : 1064 -1069 .
Roos, J. F., Doust, J., Tett, S. E., et al.: Diagnostic accuracy of cystatin C compared to serum creatinine for the estimation of renal dysfunction in adults and children – a meta-analysis. Clin. Biochem., 2007, 40, 383–391.
Tett S. E. , 'Diagnostic accuracy of cystatin C compared to serum creatinine for the estimation of renal dysfunction in adults and children – a meta-analysis ' (2007 ) 40 Clin. Biochem. : 383 -391 .
Estrella, M. M., Astor, B. C., Köttgen, A., et al.: Prevalence of kidney disease in anaemia differs by GFR-estimating method: The Third National Health and Nutrition Examination Survey (1988–1994). Nephrol. Dial. Transplant., 2010, 25, 2542–2548.
Köttgen A. , 'Prevalence of kidney disease in anaemia differs by GFR-estimating method: The Third National Health and Nutrition Examination Survey (1988–1994) ' (2010 ) 25 Nephrol. Dial. Transplant. : 2542 -2548 .
Shankar, A., Lee, K. E., Klein, B. E., et al.: Estimating glomerular filtration rate in a population-based study. Vasc. Health Risk. Manag., 2010, 9, 619–627.
Klein B. E. , 'Estimating glomerular filtration rate in a population-based study ' (2010 ) 9 Vasc. Health Risk. Manag. : 619 -627 .
Wetmore, J. B., Palsson, R., Belmont, J. M., et al.: Discrepancies between creatinine- and cystatin C-based equations: Implications for identification of chronic kidney disease in the general population. Scand. J. Urol. Nephrol., 2010, 44, 242–250.
Belmont J. M. , 'Discrepancies between creatinine- and cystatin C-based equations: Implications for identification of chronic kidney disease in the general population ' (2010 ) 44 Scand. J. Urol. Nephrol. : 242 -250 .
Salgado, J. V., Neves, F. A., Bastos, M. G.: Monitoring renal function: measured and estimated glomerular filtration rates – a review. Braz. J. Med. Biol. Res., 2010, 43, 528–536.
Bastos M. G. , 'Monitoring renal function: measured and estimated glomerular filtration rates – a review ' (2010 ) 43 Braz. J. Med. Biol. Res. : 528 -536 .
Lee, J. Y., Choi, J. W., Kim, H.: Determination of body surface area and formulas to estimate body surface area using the alginate method. J. Physiol. Anthropol., 2008, 27, 71–82.
Kim H. , 'Determination of body surface area and formulas to estimate body surface area using the alginate method ' (2008 ) 27 J. Physiol. Anthropol. : 71 -82 .
Castilla, J. A., Álvarez, C., Aguilar, J., González-Varea, C., et al.: Influence of analytical and biological variation on the clinical interpretation of seminal parameters. Hum. Reprod., 2006, 21, 847–851.
González-Varea C. , 'Influence of analytical and biological variation on the clinical interpretation of seminal parameters ' (2006 ) 21 Hum. Reprod. : 847 -851 .
Brian, G. K., Eric, S. K., Simon, P. N., et al.: Biological variation of cystatin C: implications for the assessment of glomerular filtration rate. Clin. Chem., 1998, 44, 1535–1539.
Simon P. N. , 'Biological variation of cystatin C: implications for the assessment of glomerular filtration rate ' (1998 ) 44 Clin. Chem. : 1535 -1539 .
Bandaranayake, N., Ankrah-Tetteh, T., Wijeratne, S., et al.: Intra-individual variation in creatinine and cystatin C. Clin. Chem. Lab. Med., 2007, 45, 1237–1239.
Wijeratne S. , 'Intra-individual variation in creatinine and cystatin C. Clin ' (2007 ) 45 Chem. Lab. Med. : 1237 -1239 .
Delanaye, P., Cavalier, E., Depas, G., et al.: New data on the intraindividual variation of cystatin C. Nephron. Clin. Pract., 2008, 108, 246–248.
Depas G. , 'New data on the intraindividual variation of cystatin C ' (2008 ) 108 Nephron. Clin. Pract. : 246 -248 .
Reinhard, M., Erlandsen, E. J., Randers, E.: Biological variation of cystatin C and creatinine. Scand. J. Clin. Lab. Invest., 2009, 69, 831–836.
Randers E. , 'Biological variation of cystatin C and creatinine ' (2009 ) 69 Scand. J. Clin. Lab. Invest. : 831 -836 .
Omar, F. L., Christopher, P. P., Mitchell, G. S.: Cystatin C: An improved estimator of glomerular filtration rate? Clin. Chem., 2002, 48, 699–707.
Mitchell G. S. , 'Cystatin C: An improved estimator of glomerular filtration rate? ' (2002 ) 48 Clin. Chem. : 699 -707 .
Dharnidharka, V. R., Kwon, C., Stevens, G.: Serum cystatin C is superior to serum creatinine as a marker of kidney function: a meta-analysis. Am. J. Kidney Dis., 2002, 40, 221–226.
Stevens G. , 'Serum cystatin C is superior to serum creatinine as a marker of kidney function: a meta-analysis ' (2002 ) 40 Am. J. Kidney Dis. : 221 -226 .
Filler, G., Bökenkamp, A., Hofmann, W., et al.: Cystatin C as a marker of GFR – history, indications, and future research. Clin. Biochem., 2005, 38, 1–8.
Hofmann W. , 'Cystatin C as a marker of GFR – history, indications, and future research ' (2005 ) 38 Clin. Biochem. : 1 -8 .
Séronie-Vivien, S., Delanaye, P., Piéroni, L.: Cystatin C: current position and future prospects. Clin. Chem. Lab. Med., 2008, 46, 1664–1686.
Piéroni L. , 'Cystatin C: current position and future prospects ' (2008 ) 46 Clin. Chem. Lab. Med. : 1664 -1686 .
Stevens, L. A., Schmid, C. H., Greene, T., et al.: Factors other than glomerular filtration rate affect serum cystatin C levels. Kidney Int., 2009, 75, 652–660.
Greene T. , 'Factors other than glomerular filtration rate affect serum cystatin C levels ' (2009 ) 75 Kidney Int. : 652 -660 .
Kwong, Y. T., Stevens, L. A., Selvin, E., et al.: Imprecision of urinary iothalamate clearance as a gold-standard measure of GFR decreases the diagnostic accuracy of kidney function estimating equations. Am. J. Kidney Dis., 2010, 56, 39–49.
Selvin E. , 'Imprecision of urinary iothalamate clearance as a gold-standard measure of GFR decreases the diagnostic accuracy of kidney function estimating equations ' (2010 ) 56 Am. J. Kidney Dis. : 39 -49 .
Berg, U. B., Bäck, R., Cels, G., et al.: Comparison of plasma clearance of iohexol and urinary clearance of insulin for measurement of GFR in children. Am. J. Kidney Dis., 2011, 57, 55–61.
Cels G. , 'Comparison of plasma clearance of iohexol and urinary clearance of insulin for measurement of GFR in children ' (2011 ) 57 Am. J. Kidney Dis. : 55 -61 .
Chudleigh, R. A., Ollerton, R. L., Dunseath, G., et al.: Use of cystatin C-based estimations of glomerular filtration rate in patients with type 2 diabetes. Diabetologia, 2009, 52, 1274–1278.
Dunseath G. , 'Use of cystatin C-based estimations of glomerular filtration rate in patients with type 2 diabetes ' (2009 ) 52 Diabetologia : 1274 -1278 .
Fontseré, N., Esteve, V., Saurina, A., et al.: The search for a new marker of renal function in older patients with chronic kidney disease stages 3-4: usefulness of cystatin C-based equations. Nephron. Clin. Pract., 2009, 112, 164–170.
Saurina A. , 'The search for a new marker of renal function in older patients with chronic kidney disease stages 3-4: usefulness of cystatin C-based equations ' (2009 ) 112 Nephron. Clin. Pract. : 164 -170 .
Iliadis, F., Didangelos, T., Ntemka, A., et al.: Glomerular filtration rate estimation in patients with type 2 diabetes: creatinine- or cystatin C-based equations? Diabetologia, 2011, 54, 2987–2994.
Ntemka A. , 'Glomerular filtration rate estimation in patients with type 2 diabetes: creatinine- or cystatin C-based equations? ' (2011 ) 54 Diabetologia : 2987 -2994 .
Boudville, N., Salama, M., Jeffrey, G. P., et al.: The inaccuracy of cystatin C and creatinine-based equations in predicting GFR in orthotopic liver transplant recipients. Nephrol. Dial. Transplant., 2009, 24, 2926–2930.
Jeffrey G. P. , 'The inaccuracy of cystatin C and creatinine-based equations in predicting GFR in orthotopic liver transplant recipients ' (2009 ) 24 Nephrol. Dial. Transplant. : 2926 -2930 .
Orskov, B., Borresen, M. L., Feldt-Rasmussen, B., et al.: Estimating glomerular filtration rate using the new CKD-EPI equation and other equations in patients with autosomal dominant polycystic kidney disease. Am. J. Nephrol., 2010, 31, 53–57.
Feldt-Rasmussen B. , 'Estimating glomerular filtration rate using the new CKD-EPI equation and other equations in patients with autosomal dominant polycystic kidney disease ' (2010 ) 31 Am. J. Nephrol. : 53 -57 .
Delanaye, P., Cavalier, E., Radermecker, R. P., et al.: Estimation of GFR by different creatinine- and cystatin-C-based equations in anorexia nervosa. Clin. Nephrol., 2009, 71, 482–491.
Radermecker R. P. , 'Estimation of GFR by different creatinine- and cystatin-C-based equations in anorexia nervosa ' (2009 ) 71 Clin. Nephrol. : 482 -491 .
Stevens, L. A., Coresh, J., Schmid, C. H., et al.: Estimating GFR using serum cystatin C alone and in combination with serum creatinine: a pooled analysis of 3,418 individuals with CKD. Am. J. Kidney Dis., 2008, 51, 395–406.
Schmid C. H. , 'Estimating GFR using serum cystatin C alone and in combination with serum creatinine: a pooled analysis of 3,418 individuals with CKD ' (2008 ) 51 Am. J. Kidney Dis. : 395 -406 .
Brondén, B., Eyjolfsson, A., Blomquist, S., et al.: Evaluation of cystatin C with iohexol clearance in cardiac surgery. Acta Anaesthesiol. Scand., 2011, 55, 196–202.
Blomquist S. , 'Evaluation of cystatin C with iohexol clearance in cardiac surgery ' (2011 ) 55 Acta Anaesthesiol. Scand. : 196 -202 .
Horio, M., Imai, E., Yasuda, Y., et al.: Performance of serum cystatin C versus serum creatinine as a marker of glomerular filtration rate as measured by inulin renal clearance. Clin. Exp. Nephrol., 2011, 15, 868–876.
Yasuda Y. , 'Performance of serum cystatin C versus serum creatinine as a marker of glomerular filtration rate as measured by inulin renal clearance ' (2011 ) 15 Clin. Exp. Nephrol. : 868 -876 .
Sun, X., Chen, Y., Chen, X., et al.: Change of glomerular filtration rate in healthy adults with aging. Nephrology (Carlton), 2009, 14, 506–513.
Chen X. , 'Change of glomerular filtration rate in healthy adults with aging ' (2009 ) 14 Nephrology (Carlton) : 506 -513 .
Levey, A. S., Stevens, L. A., Schmid, C. H., et al.: CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration). A new equation to estimate glomerular filtration rate. Ann. Intern. Med., 2009, 150, 604–612.
Schmid C. H. , 'CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration). A new equation to estimate glomerular filtration rate ' (2009 ) 150 Ann. Intern. Med. : 604 -612 .
O’Callaghan, C. A., Shine, B., Lasserson, D. S.: Chronic kidney disease: a large-scale population-based study of the effects of introducing the CKD-EPI formula for eGFR reporting. BMJ Open, 2011, 1, e000308.
Lasserson D. S. , 'Chronic kidney disease: a large-scale population-based study of the effects of introducing the CKD-EPI formula for eGFR reporting ' (2011 ) 1 BMJ Open : e000308 -.
Stevens, L. A., Li, S., Kurella, T. M., et al.: Comparison of the CKD Epidemiology Collaboration (CKD-EPI) and Modification of Diet in Renal Disease (MDRD) study equations: risk factors for and complications of CKD and mortality in the Kidney Early Evaluation Program (KEEP). Am. J. Kidney Dis., 2011, 57, 9–16.
Kurella T. M. , 'Comparison of the CKD Epidemiology Collaboration (CKD-EPI) and Modification of Diet in Renal Disease (MDRD) study equations: risk factors for and complications of CKD and mortality in the Kidney Early Evaluation Program (KEEP) ' (2011 ) 57 Am. J. Kidney Dis. : 9 -16 .
Gifford, F. J., Methven, S., Boag, D. E., et al.: Chronic kidney disease prevalence and secular trends in a UK population: the impact of MDRD and CKD-EPI formulae. QJM, 2011, 104, 1045–1053.
Boag D. E. , 'Chronic kidney disease prevalence and secular trends in a UK population: the impact of MDRD and CKD-EPI formulae ' (2011 ) 104 QJM : 1045 -1053 .
Kunihiro, M., Bakhtawar, K., Mahmoodi, M. W., et al.: Comparison of risk prediction using the CKD-EPI equation and the MDRD study equation for estimated glomerular filtration rate. JAMA, 2012, 307, 1941–1951.
Mahmoodi M. W. , 'Comparison of risk prediction using the CKD-EPI equation and the MDRD study equation for estimated glomerular filtration rate ' (2012 ) 307 JAMA : 1941 -1951 .
Cepoi, V., Onofriescu, M., Segall, L., et al.: The prevalence of chronic kidney disease in the general population in Romania: a study on 60,000 persons. Int. Urol. Nephrol., 2012, 44, 213–220.
Segall L. , 'The prevalence of chronic kidney disease in the general population in Romania: a study on 60,000 persons ' (2012 ) 44 Int. Urol. Nephrol. : 213 -220 .
Murata, K., Baumann, N. A., Saenger, A. K., et al.: Relative performance of the MDRD and CKD-EPI equations for estimating glomerular filtration rate among patients with varied clinical presentations. Clin. J. Am. Soc. Nephrol., 2011, 6, 1963–1972.
Saenger A. K. , 'Relative performance of the MDRD and CKD-EPI equations for estimating glomerular filtration rate among patients with varied clinical presentations ' (2011 ) 6 Clin. J. Am. Soc. Nephrol. : 1963 -1972 .
Segarra, A., de la Torre, J., Ramos, N., et al.: Assessing glomerular filtration rate in hospitalized patients: a comparison between CKD-EPI and four cystatin C-based equations. Clin. J. Am. Soc. Nephrol., 2011, 6, 2411–2420.
Ramos N. , 'Assessing glomerular filtration rate in hospitalized patients: a comparison between CKD-EPI and four cystatin C-based equations ' (2011 ) 6 Clin. J. Am. Soc. Nephrol. : 2411 -2420 .
Shafi, T., Hoogeveen, R. C., Matsushita, K., et al.: Novel markers of kidney function as predictors of ESRD, cardiovascular disease, and mortality in the general population. Am. J. Kidney Dis., 2012, 59, 653–662.
Matsushita K. , 'Novel markers of kidney function as predictors of ESRD, cardiovascular disease, and mortality in the general population ' (2012 ) 59 Am. J. Kidney Dis. : 653 -662 .
Inker, L. A., Eckfeldt, J., Levey, A. S., et al.: Expressing the CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) cystatin C equations for estimating GFR with standardized serum cystatin C values. Am. J. Kidney Dis., 2011, 58, 682–684.
Levey A. S. , 'Expressing the CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) cystatin C equations for estimating GFR with standardized serum cystatin C values ' (2011 ) 58 Am. J. Kidney Dis. : 682 -684 .
Larsson, A., Flodin, M., Hansson, L. O., et al.: Patient selection has a strong impact on cystatin C and Modification of Diet in Renal Disease (MDRD) estimated glomerular filtration rate. Clin. Biochem., 2008, 41, 1355–1361.
Hansson L. O. , 'Patient selection has a strong impact on cystatin C and Modification of Diet in Renal Disease (MDRD) estimated glomerular filtration rate ' (2008 ) 41 Clin. Biochem. : 1355 -1361 .
Larsson, A., Palm, M., Hansson, L. O., et al.: Cystatin C and modification of diet in renal disease (MDRD) estimated glomerular filtration rate differ during normal pregnancy. Acta Obstet. Gynecol. Scand., 2010, 89, 939–944.
Hansson L. O. , 'Cystatin C and modification of diet in renal disease (MDRD) estimated glomerular filtration rate differ during normal pregnancy ' (2010 ) 89 Acta Obstet. Gynecol. Scand. : 939 -944 .
Glassock, R. J., Winearls, C.: Ageing and the glomerular filtration rate: truths and consequences. Trans. Am. Clin. Climatol. Assoc., 2009, 120, 419–428.
Winearls C. , 'Ageing and the glomerular filtration rate: truths and consequences ' (2009 ) 120 Trans. Am. Clin. Climatol. Assoc. : 419 -428 .
Kielstein, J. T., Veldink, H., Martens-Lobenhoffer, J., et al.: SDMA is an early marker of change in GFR after living-related kidney donation. Nephrol. Dial. Transplant., 2011, 26, 324–328.
Martens-Lobenhoffer J. , 'SDMA is an early marker of change in GFR after living-related kidney donation ' (2011 ) 26 Nephrol. Dial. Transplant. : 324 -328 .
Przybylowski, P., Malyszko, J., Malyszko, J. S.: Copeptin in heart transplant recipients depends on kidney function and intraventricular septal thickness. Transplant. Proc., 2010, 42, 1808–1811.
Malyszko J. S. , 'Copeptin in heart transplant recipients depends on kidney function and intraventricular septal thickness ' (2010 ) 42 Transplant. Proc. : 1808 -1811 .
Filler, G., Liu, D., Huang, S. H., et al.: Impaired GFR is the most important determinant for FGF-23 increase in chronic kidney disease. Clin. Biochem., 2011, 44, 435–437.
Huang S. H. , 'Impaired GFR is the most important determinant for FGF-23 increase in chronic kidney disease ' (2011 ) 44 Clin. Biochem. : 435 -437 .
Tang, W. H., Shrestha, K., Shao, Z., et al.: Usefulness of plasma galectin-3 levels in systolic heart failure to predict renal insufficiency and survival. Am. J. Cardiol., 2011, 108, 385–390.
Shao Z. , 'Usefulness of plasma galectin-3 levels in systolic heart failure to predict renal insufficiency and survival ' (2011 ) 108 Am. J. Cardiol. : 385 -390 .