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  • 1 Kanizsai Dorottya Kórház Központi Laboratórium Nagykanizsa Szekeres J. út 2–8. 8800
  • 2 Semmelweis Egyetem, Általános Orvostudományi Kar Transzplantációs és Sebészeti Klinika, Központi Laboratórium Budapest
  • 3 Szent Imre Kórház, Dél-budai Nefrológiai Központ Nefrológiai Profil és B. Braun Avitum Hungary Zrt. 1. Sz. Dialízisközpont Budapest
Open access

Bevezetés: Krónikus vesebetegségben elengedhetetlen a glomerulusfiltrációs ráta ismerete, mivel annak mértéke határozza meg a stádiumokat, és iránymutató a kezelés szempontjából. Célkitűzés: A szerzők két, a standardizált kreatininen, valamint öt immunturbidimetriás cisztatin-C-meghatározáson alapuló becsült glomerulusfiltrációs ráta egyenletét vizsgálták. Módszer: Az analitok és az egyenletek eloszlását, kapcsolataikat, a becsült glomerulusfiltrációs ráták közötti különbségeket és stádiumbesorolásaikat tanulmányozták. Eredmények: A cisztatin-C-képletek több beteget soroltak az 1-es stádiumba, míg a kreatinines képletek a 2-es, 3-as és 4-esbe. Az 5. stádiumba a Grubb1-, Grubb2- és Larsson-képletek több, míg a Tan- és Sjöström-képletek kevesebb beteget soroltak, mint a kreatinines képletek. Legjobban a Grubb1- és Grubb2-egyenletek stádiumbesorolásai hasonlítottak egymásra. A 3–5. stádiumok legritkábban a Sjöström-képlet esetében fordultak elő. Következtetések: A különböző képletekkel számolt becsült glomerulusfiltrációs ráták szignifikánsan befolyásolhatják a stádiumbeosztást, így a betegek kezelését és kilátásaik becslését is. Orv. Hetil., 2013, 154, 415–425.

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