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  • 1 Semmelweis Egyetem, Általános Orvostudományi Kar II. Belgyógyászati Klinika Budapest Szentkirályi u. 46. 1088
  • 2 Magyar Tudományos Akadémia–Semmelweis Egyetem Molekuláris Medicina Kutatócsoport Budapest
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Az overlap szindróma az autoimmun májbetegségek közötti biokémiai, szerológiai, hisztológiai vagy radiológiai átfedéseket, az autoimmun hepatitis és primer biliaris cirrhosis vagy primer szklerotizáló cholangitis együttes fennállását jelenti. Pontos gyakoriságuk nem ismert, 5–20%-os előfordulásról számolnak be. Az overlap szindrómáknak nincs kórjelző diagnosztikus vizsgálata, a klinikai tünetek, biokémiai, szerológiai, radiológiai és hisztológiai vizsgálatok eredményének együttes értékelésén alapul a kórisme. A domináns megjelenésen alapuló, egyénre szabott, urzodezoxikólsavval végzett és/vagy immunszuppresszív (kortikoszteroid-) kezelést a tapasztalatok, illetve retrospektív, nem randomizált vizsgálatok eredményei alapozzák meg. Orv. Hetil., 2013, 154, 923–929.

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