Bevezetés: Az adenoid cysticus carcinoma a nyálmirigyeket érintő rosszindulatú daganat, ritkán azonban az emlő mirigyeiből is kiindulhat. A nyálmirigyből kiinduló forma nagyon agresszív kimenetelt mutat, az emlőmirigy adenoid cysticus tumora azonban általában igen kedvező prognózissal bír. Célkitűzés: A szerzők célul tűzték ki az emlőmirigyből és nyálmirigyből kiinduló adenoid cysticus carcinoma esetek miRNS-mintázatának összehasonlítását. Módszer: Két-két, emlőből és nyálmirigyből származó adenoid cysticus carcinoma és egy-egy normális emlő- és nyálmirigyszövetet vizsgáltak. A miRNS-profilt Affymetrix® Gene Chip segítségével határozták meg. Eredmények: Egyes miRNS-ek expressziója emlő- és nyálmirigy-eredetű tumorokban eltért a normális kontrolljukhoz képest: a let-7b expressziója a nyálmirigy-eredetű tumorokban fokozott, míg emlőmirigyből származó adenoid cysticus carcinoma szövetekben csökkent volt, a miR-24 expressziója pedig ezzel ellentétesen változott: emlőeredetű adenoid cysticus carcinoma szövetekben emelkedést mutatott, míg a nyálmirigy tumoraiban csökkent mértékben expresszálódott. A miR-181a-2* kizárólag a nyálmirigy-eredetű adenoid cysticus carcinoma esetekben volt detektálható. Következtetések: A gének poszttranszkripcionális szabályozása révén egyes miRNS-ek eltérő expressziója részleges magyarázatot adhat a két szerv adenoid cysticus tumorainak eltérő klinikai lefolyására. Orv. Hetil., 2013, 154, 963–968.
Reyes, C., Jorda, M., Gomez-Fernandez, C.: Salivary gland-like tumors of the breast express basal-type immunohistochemical markers. Appl. Immunohistochem. Mol. Morphol., 2012 Aug 29. [Epub ahead of print] doi: 10.1097/PAI.0b013e31826a277e
Ghabach, B., Anderson, W. F., Curtis, R. E., et al.: Adenoid cystic carcinoma of the breast in the United States (1977 to 2006): a population-based cohort study. Breast Cancer Res., 2010, 12, R54.
Curtis R. E. , 'Adenoid cystic carcinoma of the breast in the United States (1977 to 2006): a population-based cohort study ' (2010 ) 12 Breast Cancer Res. : R54 -.
Ciccolallo, L., Licitra, L., Cantú, G., et al.: Survival from salivary glands adenoid cystic carcinoma in European populations. Oral Oncol., 2009, 45, 669–674.
Cantú G. , 'Survival from salivary glands adenoid cystic carcinoma in European populations ' (2009 ) 45 Oral Oncol. : 669 -674 .
Bjorndal, K., Krogdahl, A., Therkildsen, M. H., et al.: Salivary gland carcinoma in Denmark 1990–2005: a national study of incidence, site and histology. Results of the Danish Head and Neck Cancer Group (DAHANCA). Oral Oncol., 2011, 47, 677–682.
Therkildsen M. H. , 'Salivary gland carcinoma in Denmark 1990–2005: a national study of incidence, site and histology. Results of the Danish Head and Neck Cancer Group (DAHANCA) ' (2011 ) 47 Oral Oncol. : 677 -682 .
Moskaluk, C. A.: Adenoid cystic carcinoma: clinical and molecular features. Head Neck Pathol., 2013, 7, 17–22.
Moskaluk C. A. , 'Adenoid cystic carcinoma: clinical and molecular features ' (2013 ) 7 Head Neck Pathol. : 17 -22 .
Glazebrook, K. N., Reynolds, C., Smith, R. L., et al.: Adenoid cystic carcinoma of the breast. AJR Am. J. Roentgenol., 2010, 194, 1391–1396.
Smith R. L. , 'Adenoid cystic carcinoma of the breast ' (2010 ) 194 AJR Am. J. Roentgenol. : 1391 -1396 .
Boujelbene, N., Khabir, A., Jeanneret Sozzi, W., et al.: Clinical review – breast adenoid cystic carcinoma. Breast, 2012, 21, 124–127.
Jeanneret Sozzi W. , 'Clinical review – breast adenoid cystic carcinoma ' (2012 ) 21 Breast : 124 -127 .
Perou, C. M., Sørlie, T., Eisen, M. B., et al.: Molecular portraits of human breast tumours. Nature, 2010, 406, 747–752.
Eisen M. B. , 'Molecular portraits of human breast tumours ' (2010 ) 406 Nature : 747 -752 .
Goldhirsch, A., Wood, W. C., Coates, A. S., et al.: Strategies for subtypes – dealing with the diversity of breast cancer: highlights of the St. Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2011. Ann. Oncol., 2011, 22, 1736–1747.
Coates A. S. , 'Strategies for subtypes – dealing with the diversity of breast cancer: highlights of the St. Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2011 ' (2011 ) 22 Ann. Oncol. : 1736 -1747 .
Penault-Llorca, F., André, F., Sagan, C., et al.: Ki67 expression and docetaxel efficacy in patients with estrogen receptor-positive breast cancer. J. Clin. Oncol., 2009, 27, 2809–2815.
Sagan C. , 'Ki67 expression and docetaxel efficacy in patients with estrogen receptor-positive breast cancer ' (2009 ) 27 J. Clin. Oncol. : 2809 -2815 .
Sørlie, T., Perou, C. M., Tibshirani, R., et al.: Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc. Natl. Acad. Sci. USA., 2001, 98, 10869–10874.
Tibshirani R. , 'Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications ' (2001 ) 98 Proc. Natl. Acad. Sci. USA. : 10869 -10874 .
Bartel, D. P.: MicroRNAs: genomics, biogenesis, mechanism, and function. Cell, 2004, 116, 281–297.
Bartel D. P. , 'MicroRNAs: genomics, biogenesis, mechanism, and function ' (2004 ) 116 Cell : 281 -297 .
Babak, T., Zhang, W., Morris, Q., et al.: Probing microRNAs with microarrays: tissue specificity and functional inference. RNA, 2004, 10, 1813–1819.
Morris Q. , 'Probing microRNAs with microarrays: tissue specificity and functional inference ' (2004 ) 10 RNA : 1813 -1819 .
Persson, M., Andrén, Y., Mark, J., et al.: Recurrent fusion of MYB and NFIB transcription factor genes in carcinomas of the breast and head and neck. Proc. Natl. Acad. Sci. USA, 2009, 106, 18740–18744.
Mark J. , 'Recurrent fusion of MYB and NFIB transcription factor genes in carcinomas of the breast and head and neck ' (2009 ) 106 Proc. Natl. Acad. Sci. USA : 18740 -18744 .
Miao, R. Y., Drabsch, Y., Cross, R. S., et al.: MYB is essential for mammary tumorigenesis. Cancer Res., 2011, 71, 7029–7037.
Cross R. S. , 'MYB is essential for mammary tumorigenesis ' (2011 ) 71 Cancer Res. : 7029 -7037 .
Mitani, Y., Li, J., Rao, P. H., et al.: Comprehensive analysis of the MYB-NFIB gene fusion in salivary adenoid cystic carcinoma: Incidence, variability, and clinicopathologic significance. Clin. Cancer Res., 2010, 16, 4722–4731.
Rao P. H. , 'Comprehensive analysis of the MYB-NFIB gene fusion in salivary adenoid cystic carcinoma: Incidence, variability, and clinicopathologic significance ' (2010 ) 16 Clin. Cancer Res. : 4722 -4731 .
Pastolero, G., Hanna, W., Zbieranowski, I., et al.: Proliferative activity and p53 expression in adenoid cystic carcinoma of the breast. Mod. Pathol., 1996, 9, 215–219.
Zbieranowski I. , 'Proliferative activity and p53 expression in adenoid cystic carcinoma of the breast ' (1996 ) 9 Mod. Pathol. : 215 -219 .
Marchiò, C., Weigelt, B., Reis-Filho, J. S.: Adenoid cystic carcinomas of the breast and salivary glands (or ‘The strange case of Dr Jekyll and Mr Hyde’ of exocrine gland carcinomas). J. Clin. Pathol., 2010, 63, 220–228.
Reis-Filho J. S. , 'Adenoid cystic carcinomas of the breast and salivary glands (or ‘The strange case of Dr Jekyll and Mr Hyde’ of exocrine gland carcinomas) ' (2010 ) 63 J. Clin. Pathol. : 220 -228 .
Houbaviy, H. B., Murray, M. F., Sharp, P. A.: Embryonic stem cell-specific microRNAs. Dev. Cell, 2003, 5, 351–358.
Sharp P. A. , 'Embryonic stem cell-specific microRNAs ' (2003 ) 5 Dev. Cell : 351 -358 .
Park, S. Y., Jeong, H. J., Yang, W. M., et al.: Implications of microRNAs in the pathogenesis of diabetes. Arch. Pharm. Res., 2013, 36, 154–166.
Yang W. M. , 'Implications of microRNAs in the pathogenesis of diabetes ' (2013 ) 36 Arch. Pharm. Res. : 154 -166 .
Kornfeld, J. W., Baitzel, C., Könner, A. C., et al.: Obesity-induced overexpression of miR-802 impairs glucose metabolism through silencing of Hnf1b. Nature, 2013, 494, 111–115.
Könner A. C. , 'Obesity-induced overexpression of miR-802 impairs glucose metabolism through silencing of Hnf1b ' (2013 ) 494 Nature : 111 -115 .
Vickers, K. C., Sethupathy, P., Baran-Gale, J., et al.: Complexity of microRNA function and the role of isomiRs in lipid homeostasis. J. Lipid Res., 2013, 54, 1182–1191.
Baran-Gale J. , 'Complexity of microRNA function and the role of isomiRs in lipid homeostasis ' (2013 ) 54 J. Lipid Res. : 1182 -1191 .
Madrigal-Matute, J., Rotllan, N., Aranda, J. F., et al.: MicroRNAs and atherosclerosis. Curr. Atheroscler. Rep., 2013, 15, 322.
Aranda J. F. , 'MicroRNAs and atherosclerosis ' (2013 ) 15 Curr. Atheroscler. Rep. : 322 -.
Fiedler, J., Thum, T.: MicroRNAs in myocardial infarction. Arterioscler. Thromb. Vasc. Biol., 2013, 33, 201–205.
Thum T. , 'MicroRNAs in myocardial infarction ' (2013 ) 33 Arterioscler. Thromb. Vasc. Biol. : 201 -205 .
Tömböl, Z., Szabó, P., Rácz, K., et al.: Relevance of microRNA-s in neoplastic diseases. [MicroRNS-ek jelentősége daganatokban.] Orv. Hetil., 2007, 148, 1135–1141. [Hungarian]
Rácz K. , 'Relevance of microRNA-s in neoplastic diseases. [MicroRNS-ek jelentősége daganatokban.] ' (2007 ) 148 Orv. Hetil. : 1135 -1141 .
Krutovskikh, V. A., Herceg, Z.: Oncogenic microRNAs (oncomiRs) as a new class of cancer biomarkers. Bioessays, 2010, 32, 894–904.
Herceg Z. , 'Oncogenic microRNAs (oncomiRs) as a new class of cancer biomarkers ' (2010 ) 32 Bioessays : 894 -904 .
Zheng, D., Haddadin, S., Wang, Y., et al.: Plasma microRNAs as novel biomarkers for early detection of lung cancer. Int. J. Clin. Exp. Pathol., 2011, 4, 575–586.
Wang Y. , 'Plasma microRNAs as novel biomarkers for early detection of lung cancer ' (2011 ) 4 Int. J. Clin. Exp. Pathol. : 575 -586 .
Lee, J. H., Voortman, J., Dingemans, A. M., et al.: MicroRNA expression and clinical outcome of small cell lung cancer. PLoS One, 2011, 6, e21300.
Dingemans A. M. , 'MicroRNA expression and clinical outcome of small cell lung cancer ' (2011 ) 6 PLoS One : e21300 -.
Kim, S. J., Shin, J. Y., Lee, K. D., et al.: MicroRNA let-7a suppresses breast cancer cell migration and invasion through downregulation of C-C chemokine receptor type 7. Breast Cancer Res., 2012, 14, R14.
Lee K. D. , 'MicroRNA let-7a suppresses breast cancer cell migration and invasion through downregulation of C-C chemokine receptor type 7 ' (2012 ) 14 Breast Cancer Res. : R14 -.
Song, B., Wang, C., Liu, J., et al.: MicroRNA-21 regulates breast cancer invasion partly by targeting tissue inhibitor of metalloproteinase 3 expression. J. Exp. Clin. Cancer Res., 2010, 29, 29.
Liu J. , 'MicroRNA-21 regulates breast cancer invasion partly by targeting tissue inhibitor of metalloproteinase 3 expression ' (2010 ) 29 J. Exp. Clin. Cancer Res. : 29 -.
Schee, K., Fodstad, Ø., Flatmark, K.: MicroRNAs as biomarkers in colorectal cancer. Am. J. Pathol., 2010, 177, 1592–1599.
Flatmark K. , 'MicroRNAs as biomarkers in colorectal cancer ' (2010 ) 177 Am. J. Pathol. : 1592 -1599 .
Fang, Y. X., Gao, W. Q.: Roles of microRNAs during prostatic tumorigenesis and tumor progression. Oncogene, 2013 Mar 4. [Epub ahead of print] doi: 10.1038/onc.2013.54
Lendvai, G., Kiss, A., Kovalszky, I., et al.: MicroRNAs in hepatocarcinogenesis. [MikroRNS-ek a hepatocarcinogenesisben.] Orv. Hetil., 2012, 153, 978–989. [Hungarian]
Kovalszky I. , 'MicroRNAs in hepatocarcinogenesis. [MikroRNS-ek a hepatocarcinogenesisben.] ' (2012 ) 153 Orv. Hetil. : 978 -989 .
Zhao, S., Deng, Y., Liu, Y., et al.: MicroRNA-153 is tumor suppressive in glioblastoma stem cells. Mol. Biol. Rep., 2013, 40, 2789–2798.
Liu Y. , 'MicroRNA-153 is tumor suppressive in glioblastoma stem cells ' (2013 ) 40 Mol. Biol. Rep. : 2789 -2798 .
Zsippai, A., Szabó, D. R., Szabó, P. M., et al.: mRNA and microRNA expression patterns in adrenocortical cancer. Am. J. Cancer Res., 2011, 1, 618–628.
Szabó P. M. , 'mRNA and microRNA expression patterns in adrenocortical cancer ' (2011 ) 1 Am. J. Cancer Res. : 618 -628 .