View More View Less
  • 1 Budapesti Műszaki és Gazdaságtudományi Egyetem Vegyészmérnöki és Biomérnöki Kar Budapest
  • 2 DRC Gyógyszervizsgáló Központ Kft. Balatonfüred Ady E. u. 12. 8230
  • 3 Therapiezentrum Wolkersdorf Schwabach Németország
  • 4 Bay Zoltán Alkalmazott Kutatási Közhasznú Nonprofit Kft. Budapest
Full access

Bevezetés: A 2-es típusú cukorbetegség ma már „világjárvány”, megelőzése csak a „praediabetes” idején eredményes, ezért olyan szűrővizsgálatokra van szükség, amelyek a cukorbetegség várományosait időben felfedik. Célkitűzés: A szerzők célul tűzték ki egészséges, negatív családi anamnézisű (genetikailag nem diabeteses) és elsőfokú cukorbeteg rokonokkal rendelkező (genetikailag diabeteses), normális szénhidrát-toleranciájú és inzulinérzékenységű nőkben a diagnosztikai értékű anyagcsere-eltérések feltárását. Módszer: A klemp vizsgálatok során normális inzulinérzékenységű, genetikailag nem diabeteses (n = 26) és genetikailag diabeteses (n = 18) önkéntesek adatait elemezték. Eredmények: Genetikailag diabeteses, egészséges nőkben az orális cukorterhelés 120. percében magasabb glükóz- és inzulinkoncentrációt, valamint nagyobb magas denzitású és kisebb alacsony denzitású lipidszintet találtak a genetikailag nem diabeteses egészséges nőkben mért értékekhez képest. Következtetések: Az eredmények szerint genetikailag diabeteses, egészséges nőkben a kialakuló inzulinrezisztenciát megelőzi a hepaticus inzulinrezisztencia és a zsíranyagcsere zavara. A szerzők nem kaptak választ arra a kérdésre, hogy a cukorbetegséghez és az elhízáshoz vezető energiafelesleg miért okoz genetikailag diabeteses nőkben korán zsíranyagcsere-zavart és hyperinsulinaemiát, továbbá arra sem, hogy az elhízás miért nem társul mindig inzulinrezisztenciával. Orv. Hetil., 2013, 154, 1747–1753.

If the inline PDF is not rendering correctly, you can download the PDF file here.

  • Shaw, J. E., Sicree, R. A., Zimmet, P. Z.: Global estimates of the prevalance of diabetes for 2010 and 2030. Diabetes Res. Clin. Pract., 2010, 87, 4–14.

    Zimmet P. Z. , 'Global estimates of the prevalance of diabetes for 2010 and 2030 ' (2010 ) 87 Diabetes Res. Clin. Pract. : 4 -14.

    • Search Google Scholar
  • http://www.diabetesatlas.org/

  • Fazeli Farsani, S., van der Aa, M. P., van der Vorst, M. M. J., et al.: Global trends in the incidence and prevalance of type 2 diabetes in children and adolescents: a systematic review and evaluation of methodological approaches. Diabetologia, 2013, 56, 1471–1488.

    Vorst M. M. J. , 'Global trends in the incidence and prevalance of type 2 diabetes in children and adolescents: a systematic review and evaluation of methodological approaches ' (2013 ) 56 Diabetologia : 1471 -1488.

    • Search Google Scholar
  • Liu, L. L., Yi, J. P., Beyer, J., et al.: Type 1 and type 2 diabetes in Asian and Pacific Islander U.S. youth: the SEARCH for Diabetes in Youth Study. Diabetes Care, 2009, 32 (Suppl. 2), S133–S140.

    Beyer J. , 'Type 1 and type 2 diabetes in Asian and Pacific Islander U.S. youth: the SEARCH for Diabetes in Youth Study ' (2009 ) 32 Diabetes Care : S133 -S140.

    • Search Google Scholar
  • Mayer-Davis, E. J., Beyer, J., Bell, R. A., et al.: Diabetes in African American youth: prevalance, incidence, and clinical characteristics: the SEARCH for Diabetes in Youth Study. Diabetes Care, 2009, 32 (Suppl. 2), S112–S122.

    Bell R. A. , 'Diabetes in African American youth: prevalance, incidence, and clinical characteristics: the SEARCH for Diabetes in Youth Study ' (2009 ) 32 Diabetes Care : S112 -S122.

    • Search Google Scholar
  • Hu, F. B., Manson, J. E., Stampfer, M. J., et al.: Diet, lifestyle, and the risk of type 2 diabetes mellitus in women. N. Engl. J. Med., 2001, 345, 790–797.

    Stampfer M. J. , 'Diet, lifestyle, and the risk of type 2 diabetes mellitus in women ' (2001 ) 345 N. Engl. J. Med. : 790 -797.

    • Search Google Scholar
  • Lindström, J., Louheranta, A., Mannelin, M., et al: The Finnish Diabetes Prevention Study (DPS): Lifestyle intervention and 3-year results on diet and physical activity. Diabetes Care, 2003, 26, 3230–3236.

    Mannelin M. , 'The Finnish Diabetes Prevention Study (DPS): Lifestyle intervention and 3-year results on diet and physical activity ' (2003 ) 26 Diabetes Care : 3230 -3236.

    • Search Google Scholar
  • Chiasson, J. L., Josse, R. G., Gomis, R., et al.: Acarbose for prevention of type 2 diabetes mellitus: the STOP-NIDDM randomised trial. Lancet, 2002, 359, 2072–2077.

    Gomis R. , 'Acarbose for prevention of type 2 diabetes mellitus: the STOP-NIDDM randomised trial ' (2002 ) 359 Lancet : 2072 -2077.

    • Search Google Scholar
  • The DREAM Trial Investigators, Gerstein, H. C., Yusuf, S., Bosch, J., et al.: Effect of rosiglitazone on the frequency of diabetes in patients with impaired glucose tolerance or impaired fasting glucose: a randomised controlled trial. Lancet, 2006, 368, 1096–1105.

    Bosch J. , 'Effect of rosiglitazone on the frequency of diabetes in patients with impaired glucose tolerance or impaired fasting glucose: a randomised controlled trial ' (2006 ) 368 Lancet : 1096 -1105.

    • Search Google Scholar
  • Perreault, L., Pan, Q., Mather, K. J., et al.: Effect of regression from prediabetes to normal glucose regulation on long-term reduction in diabetes risk: results from the Diabetes Prevention Program Outcomes Study. Lancet, 2012, 379, 2243–2251.

    Mather K. J. , 'Effect of regression from prediabetes to normal glucose regulation on long-term reduction in diabetes risk: results from the Diabetes Prevention Program Outcomes Study ' (2012 ) 379 Lancet : 2243 -2251.

    • Search Google Scholar
  • Diabetes Prevention Program Research Group: Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N. Engl. J. Med., 2002, 346, 393–403.

    'Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin ' (2002 ) 346 N. Engl. J. Med. : 393 -403.

    • Search Google Scholar
  • Qi, Q., Hu, F. B.: Genetics of type 2 diabetes in European populations. J. Diabetes, 2012, 4, 203–212.

    Hu F. B. , 'Genetics of type 2 diabetes in European populations ' (2012 ) 4 J. Diabetes : 203 -212.

    • Search Google Scholar
  • Jermendy, G., Horváth, T., Littvay, L., et al.: Effect of genetic and environmental influences on cardiometabolic risk factors: a twin study. Cardiovasc. Diabetol., 2011, 10, 96. doi: 10.1186/1475-2840-10-96

    Littvay L. , 'Effect of genetic and environmental influences on cardiometabolic risk factors: a twin study ' (2011 ) 10 Cardiovasc. Diabetol. : 96 -.

    • Search Google Scholar
  • Follow-up report on the diagnosis of diabetes mellitus. The expert committee on the diagnosis and classification of diabetes mellitus. Position statment. Diabetes Care, 2003, 26, 3160–3167.

  • DeFronzo, R. A., Abdul-Ghani, M.: Assessment and treatment of cardiovascular risk in prediabetes: impaired glucose tolerance and impaired fasting glucose. Am. J. Cardiol., 2011, 108 (Suppl. 3), 3B–24B.

    Abdul-Ghani M. , 'Assessment and treatment of cardiovascular risk in prediabetes: impaired glucose tolerance and impaired fasting glucose ' (2011 ) 108 Am. J. Cardiol. : 3B -24B.

    • Search Google Scholar
  • Ikkos, D., Luft, R.: On the intravenous glucose tolerance test. Acta Endocrinol. (Copenh.), 1957, 25, 312–334.

    Luft R. , 'On the intravenous glucose tolerance test ' (1957 ) 25 Acta Endocrinol. (Copenh.) : 312 -334.

    • Search Google Scholar
  • Wareham, N. J., Phillips, D. I., Byrne, C. D., et al.: The 30 minute insulin incremental response in an oral glucose tolerance test as a measure of insulin secretion. Diabet. Med., 1995, 12, 931.

    Byrne C. D. , 'The 30 minute insulin incremental response in an oral glucose tolerance test as a measure of insulin secretion ' (1995 ) 12 Diabet. Med. : 931 -.

    • Search Google Scholar
  • A Programming Environment for Data Analysis and Graphics Version 2.15.0 ( http://cran.hu.r.-project.org )

  • Liaw, A., Wiener, M.: Classification and regression by random forest. R. News, 2000, 2, 18–22.

    Wiener M. , 'Classification and regression by random forest ' (2000 ) 2 R. News : 18 -22.

  • Kahn, S. E.: The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of type 2 diabetes. Diabetologia, 2003, 46, 3–19.

    Kahn S. E. , 'The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of type 2 diabetes ' (2003 ) 46 Diabetologia : 3 -19.

    • Search Google Scholar
  • Groop, L., Forsblom, C., Lehtovirta, M., et al.: Metabolic consequences of family history of NIDDM (the Botnia study): evidence for sex-specific parental effects. Diabetes, 1996, 45, 1585–1593.

    Lehtovirta M. , 'Metabolic consequences of family history of NIDDM (the Botnia study): evidence for sex-specific parental effects ' (1996 ) 45 Diabetes : 1585 -1593.

    • Search Google Scholar
  • Yki-Järvinen, H., Westerbacka, J.: The fatty liver and insulin resistance. Curr. Mol. Med., 2005, 5, 287–295.

    Westerbacka J. , 'The fatty liver and insulin resistance ' (2005 ) 5 Curr. Mol. Med. : 287 -295.

    • Search Google Scholar
  • Turner, N., Kowalski, G. M., Leslie, S. J., et al.: Distinct patterns of tissue-specific lipid accumulation during the induction of insulin resistance in mice by high-fat feeding. Diabetologia, 2013, 56, 1638–1648.

    Leslie S. J. , 'Distinct patterns of tissue-specific lipid accumulation during the induction of insulin resistance in mice by high-fat feeding ' (2013 ) 56 Diabetologia : 1638 -1648.

    • Search Google Scholar
  • Chan, D. C., Watts, G. F., Ng, T. W., et al.: Measurement of liver fat by magnetic resonance imaging: relationships with body fat distribution, insulin sensitivity and plasma lipids in healthy men. Diabetes Obes. Metab., 2006, 8, 698–702.

    Ng T. W. , 'Measurement of liver fat by magnetic resonance imaging: relationships with body fat distribution, insulin sensitivity and plasma lipids in healthy men ' (2006 ) 8 Diabetes Obes. Metab. : 698 -702.

    • Search Google Scholar
  • Elgzyri, T., Parikh, H., Zhou, Y., et al.: First-degree relatives of type 2 diabetic patients have reduced expression of genes involved in fatty acid metabolism in skeletal muscle. J. Clin. Endocrinol. Metab., 2012, 97, E1332–E1337.

    Zhou Y. , 'First-degree relatives of type 2 diabetic patients have reduced expression of genes involved in fatty acid metabolism in skeletal muscle ' (2012 ) 97 J. Clin. Endocrinol. Metab. : E1332 -E1337.

    • Search Google Scholar
  • Fernández-Sánchez, A., Madrigal-Santillán, E., Bautista, M., et al.: Inflammation, oxidative stress and obesity. Int. J. Mol. Sci., 2011, 12, 3117–3132.

    Bautista M. , 'Inflammation, oxidative stress and obesity ' (2011 ) 12 Int. J. Mol. Sci. : 3117 -3132.

    • Search Google Scholar
  • Kehlenbrink, S., Koppaka, S., Martin, M., et al.: Elevated NEFA levels impair glucose effectiveness by increasing net hepatic glucogenolysis. Diabeteologia, 2012, 55, 3021–3028.

    Martin M. , 'Elevated NEFA levels impair glucose effectiveness by increasing net hepatic glucogenolysis ' (2012 ) 55 Diabeteologia : 3021 -3028.

    • Search Google Scholar
  • Gerber, P. A., Berneis, K.: Regulation of low-density lipoprotein subfractions by carbohydrates. Curr. Opin. Clin. Nutr. Metab. Care, 2012, 15, 381–385.

    Berneis K. , 'Regulation of low-density lipoprotein subfractions by carbohydrates ' (2012 ) 15 Curr. Opin. Clin. Nutr. Metab. Care : 381 -385.

    • Search Google Scholar
  • Bloomgarden, Z. T.: Inflammation and insulin resistance. Diabetes Care, 2003, 26, 1922–1926.

    Bloomgarden Z. T. , 'Inflammation and insulin resistance ' (2003 ) 26 Diabetes Care : 1922 -1926.

    • Search Google Scholar
  • Donath, M. Y., Shoelson, S. E.: Type 2 diabetes as an inflammatory disease. Nat. Rev. Immunol., 2011, 11, 98–107.

    Shoelson S. E. , 'Type 2 diabetes as an inflammatory disease ' (2011 ) 11 Nat. Rev. Immunol. : 98 -107.

    • Search Google Scholar
  • Buday, B., Kulcsár, E., Literáti-Nagy, B., et al.: The role of osteocalcin in the connection of bone and glucose metabolism in humans. [Az osteocalcin helye a humán cukor- és csontanyagcsere kapcsolatában.] Orv. Hetil., 2008, 149, 2453–2461. [Hungarian]

    Literáti-Nagy B. , 'The role of osteocalcin in the connection of bone and glucose metabolism in humans. [Az osteocalcin helye a humán cukor- és csontanyagcsere kapcsolatában.] ' (2008 ) 149 Orv. Hetil. : 2453 -2461.

    • Search Google Scholar
  • Ouchi, N., Parker, J. L., Lugus, J. J., et al.: Adipokines in inflammation and metabolic disease. Nat. Rev. Immunol., 2011, 11, 85–97.

    Lugus J. J. , 'Adipokines in inflammation and metabolic disease ' (2011 ) 11 Nat. Rev. Immunol. : 85 -97.

    • Search Google Scholar
  • Impact Factor (2018): 0.564
  • Medicine (miscellaneous) SJR Quartile Score (2018): Q3
  • Scimago Journal Rank (2018): 0.193
  • SJR Hirsch-Index (2018): 18

Language: Hungarian

Founded in 1857
Publication: Weekly, one volume of 52 issues annually

Senior editors

Editor(s)-in-Chief: Papp Zoltán

Read the professional career of Papp Zoltán HERE.

 

Editorial Board

Click for the Editorial Board

Akadémiai Kiadó
Address: Prielle Kornélia u. 21-35. H-1117 Budapest, Hungary
Phone: (+36 1) 464 8235 ---- Fax: (+36 1) 464 8221
Email: orvosihetilap@akkrt.hu

The author instructions are available in PDF.
Instructions for Authors in Hungarian HERE.

Mendeley citation style is available HERE.

 

MANUSCRIPT SUBMISSION