Orvosi Hetilap
Volume/Issue:
Volume 156: Issue 22
A sarcoma synoviale kezelési lehetőségei
Authors: Dániel Deme 1 and András Telekes 1 , 2
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  • 1 Szent Lázár Megyei Kórház, Salgótarján, Füleki út 54–56., 3100
  • 2 Bajcsy-Zsilinszky Kórház, Budapest
DOI:
https://doi.org/10.1556/650.2015.30166
Page Count:
875–880
Publication Date:
01 May 2015
Online Publication Date:
May 2015
Article Category:
Review Article
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Absztrakt

A sarcoma synoviale a lágyrész-sarcomák 5–10%-ában, az összes malignus daganatok 0,05–0,1%-ában fordul elő. Főként a végtagokon keletkezik, azonban bárhol kialakulhat. A betegek 50%-ában 3–5 éven belül metasztázisok jelennek meg (tüdő, nyirokcsomó, csont), sőt akár 20 év elteltével is számítani lehet a sarcoma synoviale kiújulására. Az 5 éves teljes túlélés lokalizált betegség esetén 76%, metasztatikus esetben 10%. Az életkor, daganatméret, szövettani altípus és a radioterápia megtörténte befolyásolja a prognózist. Az adjuváns kemoterápia szerepe nem bizonyított. Számos klinikai vizsgálat van folyamatban a lokálisan előrehaladott, relaptálódott/refrakter és metasztatikus sarcoma synoviale kezelésére. A sarcoma synoviale biológiai viselkedésének jobb megértésével a célzott kezelés és a konvencionális terápia kombinációja válhat a jövő útjává. Orv. Hetil., 2015, 156(22), 875–880.

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Cover Orvosi Hetilap
Orvosi Hetilap
Print ISSN:
0030-6002
Online ISSN:
1788-6120
Keywords:
sarcoma synoviale; kemoterápia; radioterápia; célzott kezelés; synovial sarcoma; chemotherapy; radiotherapy; targeted therapy

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