Orvosi Hetilap
Volume/Issue:
Volume 157: Issue 34
Tumorőssejtek szerepe a melanoma progressziójában és heterogenitásában
Authors: Balázs Széky 1 , Pálma Silló 2 , Melinda Fábián 2 , Balázs Mayer 2 , Sarolta Kárpáti 2 , and Krisztián Németh 2
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  • 1 Pázmány Péter Katolikus Egyetem, Budapest
  • 2 Semmelweis Egyetem, Általános Orvostudományi Kar, Budapest
DOI:
https://doi.org/10.1556/650.2016.30487
Page Count:
1339–1348
Publication Date:
01 Aug 2016
Online Publication Date:
Aug 2016
Article Category:
Review Article
Open access

Absztrakt

A szolid és hematológiai tumorok legtöbbjében mára olyan sejtpopulációkat azonosítottak, amelyek a daganatok kis százalékát alkotják, mégis kiemelkedő szerepet töltenek be a daganat terjedésének előmozdításában. Ezek az úgynevezett tumorőssejtek a szomatikus és embrionális őssejtekhez hasonló viselkedést mutatnak, aszimmetrikus osztódással önmegújításra képesek és heterogén sejtpopulációkat is létrehoznak. Egyre több kutatás alátámasztja, hogy a malignus melanomák progressziója mögött is tumoros őssejtek állnak. Nem tisztázott kérdés azonban, hogy a tumorigenicitásért vajon kizárólag melanomaőssejtek szubpopulációi felelősek vagy pluripotens őssejtté bármely melanomasejt dedifferenciálódhat. Jelen közlemény a pluripotens melanomaőssejtekről kíván átfogó képet nyújtani, különös tekintettel azokra a mechanizmusokra, amelyek a melanocyta-őssejtek differenciálódását szabályozzák, ugyanakkor a melanomaőssejtekben szabályozatlanul működnek. Bemutatásra kerül a mikrokörnyezet sejtjeinek, sejtadhéziós molekuláinak és szolúbilis faktorainak szerepe a melanomák progressziójában és heterogenitásának kialakulásában. Végül szó esik a melanoma terjedését leíró modellekről és azokról a sejtszintű markerekről, amelyek a melanomaőssejtek elkülönítésére, újabb célzott terápiák kifejlesztésére lehetőséget nyújthatnak. Orv. Hetil., 2016. 157(34), 1339–1348.

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Cover Orvosi Hetilap
Orvosi Hetilap
Print ISSN:
0030-6002
Online ISSN:
1788-6120
Keywords:
melanoma; tumorőssejt; mikrokörnyezet; marker; melanoma; cancer stem cell; microenvironment; marker

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