Bevezetés és célkitűzés: A Semmelweis Egyetem I. Belgyógyászati Klinikájának endoszkópos laboratóriumában vizsgálták a felső és alsó endoszkópiák indikációit, a diagnózisok megoszlását indikációk szerint, valamint a kolonoszkópiák minőségi mutatóit. Módszer: 2010. január 1. és 2011. december 31. között 2987 beteg felső és alsó endoszkópos vizsgálatának adatait elemezték (férfi/nő: 1361/1626, átlagéletkor: 60,7 év, SD: 16,7 év) a fekvő- és járóbeteg-megjelenések riportjaiból. Eredmények: A felső endoszkópiák során a jóindulatú fekélybetegség, nyelőcső-varicositas, gyomorpolip és gyomorrák előfordulási gyakorisága 10,8%, 4,5%, 6,1% és 2,9% volt. Az alsó endoszkópos vizsgálatok vastagbélpolipot, diverticulosist, daganatot és gyulladásos bélbetegséget 29,9%, 22,4%, 6,9% és 9,7%-ban írtak le. A betegek 26,3%-át vizsgálták okkult/manifeszt GI-vérzés indikációjával. A vérzés indikációjával vizsgált betegek idősebbek voltak (p<0,01), több volt a férfi (p<0,001, OR: 1,64), gyakrabban szedtek acenocoumarol- vagy heparinkészítményeket (p<0,001), gyakoribb volt a jóindulatú fekélybetegség (p<0,001, OR: 2,83) és nyelőcső-varicositas (p<0,001, OR: 2,79), a gasztroszkópiák, valamint a kolonoszkópiák során a colorectalis daganat (p<0,001, OR: 3,27). A kolonoszkópiák 81%-a volt komplett. Az inkomplett vizsgálat hátterében elégtelen előkészítés (38,2%), technikai nehézség (25,1%) és daganat miatti szűkület (20,5%) állt. Következtetés: A diagnózisok megoszlása és a minőségi mutatók (adenomatalálat, komplettálási arány) megfeleltek az adott populációban várhatónak. Orv. Hetil., 2016, 157(52), 2074–2081.
ASGE Standards of Practice Committee, Early, D. S., Ben-Menachem, T., Decker, G. A., et al.: Appropriate use of GI endoscopy. Gastrointest. Endosc., 2012, 75(6), 1127–1131.
Blatchford, O., Davidson, L. A., Murray, W. R., et al.: Acute upper gastrointestinal haemorrhage in west of Scotland: case ascertainment study. BMJ, 1997, 315(7107), 510–514.
Yavorski, R. T., Wong, R. K., Maydonovitch, C., et al.: Analysis of 3,294 cases of upper gastrointestinal bleeding in military medical facilities. Am. J. Gastroenterol., 1995, 90(4), 568–573.
Longstreth, G. F.: Epidemiology and outcome of patients hospitalized with acute lower gastrointestinal hemorrhage: a population-based study. Am. J. Gastroenterol., 1997, 92(3), 419–424.
Hreinsson, J. P., Gumundsson, S., Kalaitzakis, E., et al.: Lower gastrointestinal bleeding: incidence, etiology, and outcomes in a population-based setting. Eur. J. Gastroenterol. Hepatol., 2013, 25(1), 37–43.
Esrailian, E., Gralnek, I. M.: Nonvariceal upper gastrointestinal bleeding: epidemiology and diagnosis. Gastroenterol. Clin. North Am., 2005, 34(4), 589–605.
Strate, L. L.: Lower GI bleeding: epidemiology and diagnosis. Gastroenterol. Clin. North Am., 2005, 34(4), 643–664.
Lanas, A., García-Rodríguez, L. A., Polo-Tomás, M., et al.: Time trends and impact of upper and lower gastrointestinal bleeding and perforation in clinical practice. Am. J. Gastroenterol., 2009, 104(7), 1633–1641.
Van Leerdam, M. E., Vreeburg, E. M., Rauws, E. A., et al.: Acute upper GI bleeding: did anything change? Time trend analysis of incidence and outcome of acute upper GI bleeding between 1993/1994 and 2000. Am. J. Gastroenterol., 2003, 98(7), 1494–1499.
Loperfido, S., Baldo, V., Piovesana, E., et al.: Changing trends in acute upper-GI bleeding: a population-based study. Gastrointest. Endosc., 2009, 70(2), 212–224.
Rácz, I., Kárász, T., Lukács, K., et al.: Management of peptic ulcer bleeding in different case volume workplaces: results of a nationwide inquiry in Hungary. Gastroenterol. Res. Pract., 2012, 2012, Article ID 956434.
Szőcs, K., Kárász, T., Saleh, H., et al.: The value of routine second-look endoscopy in the management of the acute gastroduodenal ulcer bleeding. [A tervezett ellenőrző endoszkópia értéke az akut gastroduodenalis fekélyvérzés ellátásában.] Orv. Hetil., 2009, 150(42), 1932–1936. [Hungarian]
Dávid, G., Mester, G., Pandúr, T., et al.: Management strategies of acute lower gastrointestinal bleeding (ALGIB) of our department. Results of the last two years (2004–2005). Z. Gastroenterol., 2006, 44(5), A19.
Peery, A. F., Dellon, E. S., Lund, J., et al.: Burden of gastrointestinal disease in the United States: 2012 update. Gastroenterology, 2012, 143(5), 1179–1187.e3
Wanders, L. K., van Doorn, S. C., Fockens, P., et al.: Quality of colonoscopy and advances in detection of colorectal lesions: a current overview. Expert Rev. Gastroenterol. Hepatol., 2015, 9(4), 417–430.
ASGE Standards of Practice Committee, Pasha, S. F., Shergill, A., Acosta, R. D., et al.: The role of endoscopy in the patient with lower GI bleeding. Gastrointest. Endosc., 2014, 79(6), 875–885.
Bressler, B., Paszat, L. F., Chen, Z., et al.: Rates of new or missed colorectal cancers after colonoscopy and their risk factors: a population-based analysis. Gastroenterology, 2007, 132(1), 96–102.
Hosokawa, O., Shirasaki, S., Kaizaki, Y., et al.: Invasive colorectal cancer detected up to 3 years after a colonoscopy negative for cancer. Endoscopy, 2003, 35(6), 506–510.
Farrar, W. D., Sawhney, M. S., Nelson, D. B., et al.: Colorectal cancers found after a complete colonoscopy. Clin. Gastroenterol. Hepatol., 2006, 4(10), 1259–1264.
Gellad, Z. F., Voils, C. I., Lin, L. et al.: Physician perceptions on colonoscopy quality: results of a National Survey of Gastroenterologists. Gastroenterol. Res. Pract., 2014, 2014, Article ID 510494.
Rex, D. K., Bond, J. H., Winawer, S., et al.: Quality in the technical performance of colonoscopy and the continuous quality improvement process for colonoscopy: recommendations of the U.S. Multi-Society Task Force on Colorectal Cancer. Am. J. Gastroenterol., 2002, 97(6), 1296–1308.
Van Leerdam, M. E.: Epidemiology of acute upper gastrointestinal bleeding. Best Pract. Res. Clin. Gastroenterol., 2008, 22(2), 209–224.
Fonseca, J., Alves, C. C., Neto, R., et al.: Nonvariceal upper gastrointestinal bleeding in Portugal: A multicentric retrospective study in twelve Portuguese hospitals. Gastroenterol. Hepatol., 2012, 35(6), 377–385.
Lanas, A., Aabakken, L., Fonseca, J., et al.: Variability in the management of nonvariceal upper gastrointestinal bleeding in Europe: an observational study. Adv. Ther., 2012, 29(12), 1026–1036.
Kim, J. J., Sheibani, S., Park, S., et al.: Causes of bleeding and outcomes in patients hospitalized with upper gastrointestinal bleeding. J. Clin. Gastroenterol., 2014, 48(2), 113–118.
Zuccaro, G.: Epidemiology of lower gastrointestinal bleeding. Best Prac. Res. Clin. Gastroenterol., 2008, 22(2), 225–232.
Strate, L. L., Ayanian, J. Z., Kotler, G., et. al.: Risk factors for mortality in lower intestinal bleeding. Clin. Gastroenterol. Hepatol., 2008, 6(9), 1004–1010.
Zullo, A., Esposito, G., Ridola, L., et al.: Prevalence of lesions detected at upper endoscopy: An Italian survey. Eur. J. Intern. Med., 2014, 25(8), 772–776.
Park, W. G., Shaheen, N. J., Cohen, J., et al.: Quality indicators for EGD. Gastrointestinal Endoscopy, 2015, 81(1), 17–30.
Voutilainen, M., Mäntynen, T., Färkkilä, M., et al.: Impact of nonsteroidal anti-inflammatory drug and aspirin use on the prevalence of dyspepsia and uncomplicated peptic ulcer disease. Scand. J. Gastroenterol., 2001, 36(8), 817–821.
Lassen, A., Hallas, J., De Muckadell, O. B., et al.: First-time endoscopy and use of antisecretory medication: a population-based cohort study. Scand. J. Gastroenterol., 2005, 40(6), 705–712.
Thomson, A. B., Barkun, A. N., Armstrong, D., et al.: The prevalence of clinically significant endoscopic findings in primary care patients with uninvestigated dyspepsia: the Canadian Adult Dyspepsia Empiric Treatment – Prompt Endoscopy (CADET-PE) study. Aliment. Pharmacol. Ther., 2003, 17(12), 1481–1491.
Buri, L., Zullo, A., Hassan, C., et al.: Upper GI endoscopy in elderly patients: predictive factors of relevant endoscopic findings. Intern. Emerg. Med., 2013, 8(2), 141–146.
Triantos, C., Kalafateli, M., et al.: Endoscopic treatment of esophageal varices in patients with liver cirrhosis. World J. Gastroenterol., 2014, 20(36), 13015–13026.
Singh, H., Kaita, L., Taylor, G., et al.: Practice and documentation of performance of colonoscopy in a central Canadian health region. Can. J. Gastroenterol. Hepatol., 2014, 28(4), 185–190.
Rai, T., Navaneethan, U., Gohel, T., et al.: Effect of quality of bowel preparation on quality indicators of adenoma detection rates and colonoscopy completion rates. Gastroenterol. Rep. (Oxf.), 2016, 4(2), 148–153.
Rembacken, B., Hassan, C., Riemann, J. F., et al.: Quality in screening colonoscopy: position statement of the European Society of Gastrointestinal Endoscopy (ESGE). Endoscopy, 2012, 44(10), 957–968.
Altenhofen, L., Kretschmann, J., et al.: Trends in adenoma detection rates during the first 10 years of the German Screening Colonoscopy Program. Gastroenterology, 2015, 149(2), 356–366.
Lieberman, D. A., Weiss, D. G., Bond, J. H., et al.: Use of colonoscopy to screen asymptomatic adults for colorectal cancer. Veterans Affairs Cooperative Study Group 380. N. Engl. J. Med., 2000, 343(3), 162–168.
Ure, T., Dehghan, K., Vernava, A. M. 3rd, et al.: Colonoscopy in the elderly. Low risk, high yield. Surg. Endosc., 1995, 9(5), 505–508.
Karajeh, M. A., Sanders, D. S., Hurlstone, D. P., et al.: Colonoscopy in elderly people is a safe procedure with a high diagnostic yield: a prospective comparative study of 2000 patients. Endoscopy, 2006, 38(3), 226–230.
Manousos, O. N., Truelove, S. C., Lumsden, K., et al.: Prevalence of colonic diverticulosis in general population of Oxford area. Br. Med. J., 1967, 3(5568), 762–763.
Gohil, V. B., Patrie, J. T., Shami, V. M., et al.: Colonic diverticulosis is associated with an increased adenoma detection rate in patients undergoing first-time screening colonoscopy. J. Interv. Gastroenterol., 2012, 2(2), 70–75.
Zuckerman, G. R., Prakash, C., Askin, M. P., et al.: AGA technical review on the evaluation and management of occult and obscure gastrointestinal bleeding. Gastroenterology, 2000, 118(1), 201–221.
Rockall, T. A., Logan, R. F., Devlin, H. B., et al.: Incidence of and mortality from acute upper gastrointestinal haemorrhage in the United Kingdom. Steering committee and members of the National Audit of Acute Upper Gastrointestinal Haemorrhage. BMJ, 1995, 311(6999) 222–226.
Czernichow, P., Hochain, P., Nousbaum, J. B., et al.: Epidemiology and course of acute upper gastro-intestinal haemorrhage in four French geographical areas. Eur. J. Gastroenterol. Hepatol., 2000, 12(2), 175–181.
Lingenfelser, T., Ell, C.: Lower intestinal bleeding. Best Pract. Res. Clin. Gastroenterol., 2001, 15(1), 135–153.
Niikura, R., Nagata, N., Shimbo, T., et al.: Natural history of bleeding risk in colonic diverticulosis patients: a long-term colonoscopy-based cohort study. Aliment. Pharmacol. Ther., 2015, 41(9), 888–894.
Rex, D. K.: Colonoscopy: a review of its yield for cancers and adenomas by indication. Am. J. Gastroenterol., 1995, 90(3), 353–365.
Neely, D., Campbell, W., Davey, P., et al.: Colorectal cancer screening: the northern trust experience. Ulster Med. J., 2013, 82(3), 160–163.
Saidi, H. S., Karuri, D., Nyaim, E. O., et al.: Correlation of clinical data, anatomical site and disease stage in colorectal cancer. East Afr. Med. J., 2008, 85(6), 259–262.
Majumdar, S. R., Fletcher, R. H., Evans, A. T.: How does colorectal cancer present? Symptoms, duration, and clues to location. Am. J. Gastroenterol., 1999, 94(10), 3039–3045.
Wolfe, M. M., Lichtenstein, D. R., Singh, G.: Gastrointestinal toxicity of nonsteroidal antiinflammatory drugs. N. Engl. J. Med., 1999, 340(24), 1888–1899.
Leontiadis, G. I., Molloy-Bland, M., Moayyedi, P., et al.: Effect of comorbidity on mortality in patients with peptic ulcer bleeding: systematic review and meta-analysis. Am. J. Gastroenterol., 2013, 108(3), 331–345.
Quirke, P., Risio, M., Lambert, R., et al.: European guidelines for quality assurance in colorectal cancer screening and diagnosis. First Edition – Quality assurance in pathology in colorectal cancer screening and diagnosis. Endoscopy, 2012, 44(Suppl. 3), SE116–SE130.
Rabeneck, L., Rumble, R. B., Axler, J., et al.: Cancer Care Ontario Colonoscopy Standards: standards and evidentiary base. Can. J. Gastroenterol., 2007, 21(Supl. D), 5D–24D.
Oh, C. H., Lee, C. K., Kim, J. W.: Suboptimal bowel preparation significantly impairs colonoscopic detection of non-polypoid colorectal neoplasms. Dig. Dis. Sci., 2015, 60(8), 2294–2303.