Orvosi Hetilap
Volume/Issue:
Volume 160: Issue 17
A nátrium immunmoduláns szerepe
Authors: Róbert István Agócs 1 , Dániel Sugár 1 , Domonkos Pap 1 , 2 , and Attila J. Szabó 1 , 2
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  • 1 Semmelweis Egyetem, Általános Orvostudományi Kar, Budapest, Bókay János u. 53–54., 1083
  • 2 MTA–SE, Budapest
DOI:
https://doi.org/10.1556/650.2019.31292
Page Count:
646–653
Publication Date:
01 Apr 2019
Online Publication Date:
Apr 2019
Article Category:
Review Article
Open access

Absztrakt:

A magas sófogyasztás általános az iparosodott társadalmakban, és számos civilizációs betegség forrása. A közelmúlt kutatásai hívták fel a figyelmet a nátriumegyensúly fenntartásában szerepet játszó új extrarenalis folyamatokra. Rövid távon a bőrszövet nátriumtárolása pufferként szolgál a nátrium ozmotikus tulajdonsága következtében kialakuló, növekvő volumenterheléssel szemben, valamint elősegíti a fertőzések elleni immunválaszt. Hosszú távon azonban a fokozott szöveti nátriumkoncentráció egy adott mértéket meghaladva patofiziológiás folyamatokat indíthat be gyulladásos válaszreakció provokálásával. A nátrium immunmoduláns hatásának következtében a veleszületett és szerzett immunrendszer effektorsejtjei aktiválódnak, míg egyes szabályozósejtjei gátlás alá kerülnek, ami végeredményben az immunrendszer egyensúlyának megbomlásával, proinflammatoricus állapottal jár. In vivo sóterheléses és sómegvonásos kísérletek eredményei a nátrium betegségkiváltó és -módosító szerepére utaltak. Így a nátrium és az immunrendszer összefüggése magyarázatot adhat olyan, eddig ismeretlen eredetű betegségek patomechanizmusára, mint a magas vérnyomás (elsődleges, sószenzitív) vagy az autoimmun betegségek, melyek növekvő incidenciájuk miatt nagy terhet rónak az egészségügyi ellátórendszerre. Orv Hetil. 2019; 160(17): 646–653.

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Cover Orvosi Hetilap
Orvosi Hetilap
Print ISSN:
0030-6002
Online ISSN:
1788-6120
Keywords:
nátrium; immunmoduláció; makrofágok; T-lymphocyták; autoimmunitás; sodium; immunomodulation; macrophages; T-lymphocytes; autoimmunity

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