View More View Less
  • 1 Szegedi Tudományegyetem, Szeged
  • 2 Mosonmagyaróvári Karolina Kórház, Mosonmagyaróvár
  • 3 Szegedi Tudományegyetem, Szeged
  • 4 Szegedi Tudományegyetem, Szeged, Tisza L. krt. 111., 6722
Open access

Absztrakt:

Magyarország 2020. március 4-én jelentette az első COVID–19-fertőzésben szenvedő beteget. Az új koronavírusnak (SARS-CoV-2) az egészségügyben dolgozók vannak kitéve a legnagyobb mértékben, akik a jelenleg igazolt fertőzöttek 12%-át teszik ki. Az esetek 80%-a enyhe, középsúlyos tünetekkel vagy akár tünetmentesen zajlik. A vírus örökítőanyaga (egyszálú RNS) 30–40 napig mutatható ki RT-PCR technikával a légutakból, a vizeletből, a vérből vett mintákból és – főleg gyermekek esetében – a székletből. A szisztematikus tesztelés hiányában nincs adatunk, hogy a magyarországi járvány kezdete óta vajon hány egészségügyi dolgozó eshetett át a fertőzésen, akik maguk is kritikus fertőzőforrások lehetnek mind az általuk ellátott betegek, mind családtagjaik számára. Fontos lenne tudni keresztmetszeti és longitudinális vizsgálattal is, hogy milyen közöttük a betegséget már átvészeltek, azaz a védettek, az akut fázisban lévők, azaz a fertőzők, és a vírusnaivok, azaz a veszélyeztettek aránya. A rendelkezésre álló laboratóriumi diagnosztikai módszerek közül az RT-PCR mellett az újonnan elérhető, antitestalapú gyorstesztek jöhetnének szóba a kérdés megválaszolására, amelyek gyorsak, könnyen kivitelezhetők, olcsók, és alkalmasak lehetnek az egészségügyi dolgozók periodikus monitorizálására a SARS-CoV-2 által okozott, még ismeretlen időtartamú járvány alatt. Orv Hetil. 2020; 161(21): 854–860.

If the inline PDF is not rendering correctly, you can download the PDF file here.

  • 1

    Actual medical aspects of COVID-19 pandemic. [A COVID–19-pandémia orvosszakmai kérdései.] Orv Hetil. 2020; 161: 641–724. [Hungarian]

  • 2

    European Center for Disease Prevention and Control. Novel coronavirus disease 2019 (COVID-19) pandemic: increased transmission in the EU/EEA and the UK – sixth update. ECDC, Solna, 12 March 2020. Available from: https://www.ecdc.europa.eu/sites/default/files/documents/RRA-sixth-update-Outbreak-of-novel-coronavirus-disease-2019-COVID-19.pdf [accessed: April 19, 2020].

  • 3

    Centers for Disease Control and Prevention. Coronavirus (COVID-19). CDC, Atlanta, GA. Available from: https://www.cdc.gov/coronavirus/2019-ncov/ [accessed: April 19, 2020].

  • 4

    The Government of Hungary. Information site on coronavirus. [Magyarország Kormánya. Tájékoztató oldal a koronavírusról.] Available from: https://www.koronavirus.gov.hu [accessed: April 19, 2020]. [Hungarian]

  • 5

    EMCrit. Farkas J. The internet book of critical care (IBCC). Latest update 4/16/2020. Available from: https://emcrit.org/ibcc/covid19/ [accessed: April 19, 2020].

  • 6

    Cseresnyés P. Hungarian scientists isolate more strains of SARS-CoV-2. Hungary today, 06. 04. 2020. Available from: https://hungarytoday.hu/hungarian-scientists-isolate-more-strains-of-sars-cov-2/ [accessed: April 6, 2020].

  • 7

    Heneghan C, Brassey J, Jefferson T; Oxford COVID-19 Evidence Service Team. Sars-Cov-2 viral load and the severity of COVID-19. Center for Evidence-Based Medicine, March 26, 2020. Available from: https://www.cebm.net/covid-19/sars-cov-2-viral-load-and-the-severity-of-covid-19/ [accessed: April 19, 2020].

  • 8

    Liu WZ, Li H. COVID-19: Attacks the 1-beta chain of hemoglobin and captures the porphyrin to inhibit human heme metabolism. Preprint revised on 10. 04. 2020. Available from: https://chemrxiv.org/articles/COVID-19_Disease_ORF8_and_Surface_Glycoprotein_Inhibit_Heme_Metabolism_by_Binding_to_Porphyrin/11938173 [accessed: April 19, 2020].

  • 9

    Clarke NE, Turner AJ. Angiotensin converting enzyme 2: the first decade. Int J Hypertens. 2012; 2012: 307315.

  • 10

    Liu Y, Gayle A, Wilder-Smith A, et al. The reproductive number of COVID-19 is higher compared to SARS coronavirus. J Travel Med. 2020; 27. Doi: 10.1093/jtm/taaa021.

  • 11

    Guo X, Guo Z, Duan C, et al. Long-term persistence of IgG antibodies in SARS-CoV infected healthcare workers. February 14, 2020. Available from: https://www.medrxiv.org/content/10.1101/2020.02.12.20021386v1 [accessed: April 19, 2020].

  • 12

    Petherick A. Developing antibody tests for SARS-CoV-2. Lancet 2020; 395: 1101–1102.

  • 13

    Zhaho J, Yuan Q, Wang H, at al. Antibody responses to SARS-CoV-2 in patients of novel coronavirus disease 2019. Clin Infect Dis. 2020 Mar 28. . [Epub ahead of print]

    • Crossref
    • Export Citation
  • 14

    Dong C, Ni L, Ye F, et al. Characterization of anti-viral immunity in recovered individuals infected by SARS-CoV-2. March 20, 2020. Available from: https://www.medrxiv.org/content/10.1101/2020.03.17.20036640v1 [accessed: April 19, 2020]

  • 15

    Dong Y, Mo X, Hu Y, et al. Epidemiology of COVID-19 among children in China. Pediatrics 2020; 145: e20200702. Available from: https://doi.org/10.1542/peds.2020-070 [accessed: April 19, 2020].

  • 16

    Gursel M, Gursel I. Is global BCG vaccination coverage relevant to the progression of SARS-CoV-2 pandemic. Med Hypotheses 2020 Apr 6. . [Epub ahead of print]

    • Crossref
    • Export Citation
  • 17

    Clinicaltrials.gov. Available from: https://www.Clinicaltrials.gov [accessed: April 19, 2020].

  • 18

    Brank D. FDA OKs emergency use of convalescent plasma for seriously ill COVID-19 patients. MedScape March 28, 2020. Available from: https://www.medscape.com/viewarticle/927716 [accessed: April 19, 2020].

  • 19

    Yu F, Du L, Ojcius DM, et al. Measures for diagnosing and treating infections by a novel coronavirus responsible for a pneumonia outbreak originating in Wuhan, China. Microbes Infect. 2020; 22: 74–79.

  • 20

    Hungarian News Agency. Ten newborn infants have been infected by SARS-CoV-2 virus during the last few days in a maternity unit in Timisoara. [Magyar Távirati Iroda. Tíz újszülött fertőződött meg az új koronavírussal az elmúlt napokban egy temesvári szülészeten.] Drportal 2020 Apr 7. Available from: https://www.drportal.hu/hir.php?szid=88&tema=8&hid=26818 [accessed: April 7, 2020]. [Hungarian]

  • 21

    Rapidmicrobiology. Coronavirus (SARS-CoV-2): Test kits to detect the causative agent of COVID-19. Available from: https://www.rapidmicrobiology.com/test-method/testing-for-the-wuhan-coronavirus-a-k-a-covid-19-sars-cov-2-and-2019-ncov [accessed: April 19, 2020].

  • 22

    Diazyme Laboratories. Why do we need antibody tests for COVID-19 and how to interpret the results. Available from: http://www.diazyme.com/covid-19-antibody-tests [accessed: April 19, 2020].

  • 23

    Marty FM, Chen K, Verrill KA. How to obtain a nasopharyngeal Swab specimen. NEJM 2020 Apr 17. Doi: 10.1056/NEJMvcm2010260.

  • 24

    World Health Organization. Clinical management of severe acute respiratory infection when COVID-19 is suspected. Interim guidance. WHO, Geneva, 13 March 2020. Available from: https://www.who.int/publications-detail/clinical-management-of-severe-acute-respiratory-infection-when-novel-coronavirus-(ncov)-infection-is-suspected [accessed: April 19, 2020].

  • 25

    Zhou F, Yu T, Du R, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet 2020; 395: 1054–1062.

  • 26

    Sturts A. Comparing RT-PCR and chest CT for diagnosing COVID-19. HCP Live, March 17, 2020. Available from: https://www.mdmag.com/medical-news/comparing-rt-pcr-and-chest-ct-for-diagnosing-covid19 [accessed: April 19, 2020].

  • 27

    An J, Liao X, Xiao L, et al. Clinical characteristics of the recovered COVID-19 patients with re-detectable positive RNA test. March 30, 2020. Available from: https://www.medrxiv.org/content/10.1101/2020.03.26.20044222v1.full.pdf [accessed: April 19, 2020].

  • 28

    Pharmact Health. Sars CoV-2 rapid test. Available from: https://pharmact-health.com/en/sars-cov-2-rapid-test/ [accessed: April 19, 2020].

  • 29

    Sheridan C. Fast, portable tests come online to curb coronavirus pandemic. Nat Biotechnol. 2020 Mar 23. . [Epub ahead of print]

    • Crossref
    • Export Citation
  • 30

    Vásárhelyi B, Kristóf K, Ostorházi E, et al. The diagnostic value of rapid anti IgM and IgG detecting tests in the identification of patients with SARS CoV-2 virus infection. [A specifikus IgM- és IgG-antitesteket detektáló gyorstesztek értéke a SARS-CoV-2 vírusfertőzés kimutatásában.] Orv Hetil. 2020; 161: 807–812. [Hungarian]

  • 31

    World Health Organization. Advice on the use of point-of-care immunodiagnostic tests for COVID-19. Scientific Brief. WHO, Geneva, 8 April 2020. Available from: https://www.who.int/news-room/commentaries/detail/advice-on-the-use-of-point-of-care-immunodiagnostic-tests-for-covid-19 [accessed: Apr 19, 2020].

 

The author instructions are available in PDF.
Instructions for Authors in Hungarian HERE.

 

Mendeley citation style is available HERE.
  • Impact Factor (2019): 0.497
  • Scimago Journal Rank (2018): 0.176
  • SJR Hirsch-Index (2018): 20
  • SJR Quartile Score (2018): Q3 Medicine (miscellaneous)
  • Impact Factor (2018): 0.564
  • Scimago Journal Rank (2018): 0.193
  • SJR Hirsch-Index (2018): 18
  • SJR Quartile Score (2018): Q3 Medicine (miscellaneous)

Language: Hungarian

Founded in 1857
Publication: Weekly, one volume of 52 issues annually

Senior editors

Editor(s)-in-Chief: Papp Zoltán

Read the professional career of Papp Zoltán HERE.

 

Editorial Board

Click for the Editorial Board

Akadémiai Kiadó
Address: Prielle Kornélia u. 21-35. H-1117 Budapest, Hungary
Phone: (+36 1) 464 8235 ---- Fax: (+36 1) 464 8221
Email: orvosihetilap@akkrt.hu