Orvosi Hetilap
Volume/Issue:
Volume 161: Issue 24
Immunmediált glomerularis károsodások
Authors: Domonkos Pap 1 , 2 , Ádám Vannay 1 , 2 , and Attila Szabó J. 1 , 2
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  • 1 MTA–SE, Budapest
  • 2 Semmelweis Egyetem, Budapest, Bókay J. u. 54., 1083
DOI:
https://doi.org/10.1556/650.2020.31751
Page Count:
993–1001
Publication Date:
01 Jun 2020
Online Publication Date:
Jun 2020
Article Category:
Review Article
Open access

Absztrakt:

A vese filtrációs alapegységei a glomerulusok, melyek passzív hemodinamikai feladatukon túl komplex szabályozási mechanizmusokban is részt vesznek. Ezek közül fontosak az immunmediált folyamatok, amelyek a glomerularis homeostasis élettani biztosításán túl lokális szövetkárosító mechanizmusokat is elindíthatnak. Az immunológiai eredetű krónikus glomerularis betegségek gyakori okai a végstádiumú vesebetegség kialakulásának. Az immunrendszer kétélű kardként részt vesz a vese fiziológiás állapotának fenntartásában, de emellett meghatározó szerepe van a glomerularis károsodások kiváltásában. A nem megfelelően szabályozott, túlzott mértékű immunválasz felelős a glomerulonephritisek jelentős részéért, mely folyamat során károsodhat a glomerulusokat alkotó valamennyi strukturális és sejtes elem, beleértve a glomerularis bazálmembránt, a mesangialis és kapilláris-endothelsejteket, a podocytákat, valamint a parietalis epithelsejtréteget. Közleményünkben az egyes glomerularis komponenseknek, valamint a természetes és adaptív immunrendszernek a glomeruluskárosodásban betöltött szerepét foglaljuk össze. Orv Hetil. 2020; 161(24): 993–1001.

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Cover Orvosi Hetilap
Orvosi Hetilap
Print ISSN:
0030-6002
Online ISSN:
1788-6120
Keywords:
nephrologia; glomerulonephritis; immunválasz; nephrology; glomerulonephritis; immune system

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