A Castleman-betegség egy ritka lymphoproliferativ betegség, mely a leggyakrabban a gátorüregi nyirokcsomókat érinti. Az intrapulmonalisan elhelyezkedő forma ritkán fordul elő, az angol nyelvű irodalomban 14 eset ismert. A betegség tünetei nem specifikusak, és a diagnózis felállítása gyakran nehézségekbe ütközik. A kezelés fő célja az épben történő sebészi reszekció elérése, mely potenciális esélyt nyújt a recidívamentes túlélésre. 15 éves tünetmentes lánybetegünket ernyőszűrésen bal oldali mellkasi terimével emelték ki. A transthoracalis szövettani mintavétel megerősítette a Castleman-betegség diagnózisát. A centrálisan elhelyezkedő tumormassza érintette a tüdőkapu képleteit, ezért műtét során bal oldali teljes tüdőeltávolítás vált szükségessé a daganatmentes reszekciós szél eléréséhez. A beteg a műtétet követő 7 éves utánkövetési periódus során mindvégig recidívamentes volt. A Castleman-betegség jól kezelhető komplett sebészi reszekcióval, a betegség kiterjedése miatt azonban időnként indokolt lehet a kiterjesztett, radikális tüdőeltávolítás a tumormentes reszekciós szél eléréséhez. Orv Hetil. 2023; 164(37): 1476–1483.
Frizzera G, Banks PM, Massarelli G, et al. A systemic lymphoproliferative disorder with morphologic features of Castleman’s disease: pathological findings in 15 patients. Am J Surg Pathol. 1983; 7: 211–231.
Castleman B, Iverson L, Menendez VP. Localized mediastinal lymphnode hyperplasia resembling thymoma. Cancer 1956; 9: 822–830.
Flendrig JA, Schillings PH. Benign giant lymphoma: the clinical signs and symptoms. Folia Med Neerl. 1969; 12: 119–120.
Weisenburger DD, Nathwani BN, Winberg CD, et al. Multicentric angiofollicular lymph node hyperplasia: a clinicopathologic study of 16 cases. Hum Pathol. 1985; 16: 162–172.
Chronowski GM, Ha CS, Wilder RB, et al. Treatment of unicentric and multicentric Castleman disease and the role of radiotherapy. Cancer 2001; 92: 670–676.
Malnati MS, Dagna L, Ponzoni M, et al. Human herpesvirus 8 (HHV-8/KSHV) and hematologic malignancies. Rev Clin Exp Hematol. 2003; 7: 375–405.
Dispenzieri A. POEMS syndrome: 2019 update on diagnosis, risk‐stratification, and management. Am J Hematol. 2019; 94: 812–827.
Gündüz E, Özdemir N, Bakanay ŞM, et al. A rare lymphoproliferative disease: Castleman disease. Turk J Hematol. 2021; 38: 314–320.
Dispenzieri A, Fajgenbaum DC. Overview of Castleman disease. Blood 2020; 135: 1353–1364.
Gergely L, Illés Á. Recent advances in the understanding and treatment of diffuse large B-cell lymphoma. [A diffúz nagy B-sejtes lymhoma modern szemlélete és kezelése.] Orv Hetil. 2016; 157: 1232–1241. [Hungarian].
Jenei A, Csomor J, Sápi Z. A case of follicular dendritic cell sarcoma with challenging morphology. [Megtévesztő morfológiájú follicularis dendritikus sejtes sarcoma esete.] Hematol Transzfuz. 2021; 54: 116–117. [Hugnarian].
Simpson D. Epidemiology of Castleman disease. Hematol Oncol Clin North Am. 2018; 32: 1–10.
Carbone A, Borok M, Damania B, et al. Castleman disease. Nat Rev Dis Primers 2021; 7: 84.
Soumerai JD, Sohani AR, Abramson JS. Diagnosis and management of Castleman disease. Cancer Control 2014; 21: 266–278.
Mitsos S, Stamatopoulos A, Patrini D, et al. The role of surgical resection in unicentric Castleman’s disease: a systematic review. Adv Respir Med. 2018; 86: 36–43.
Wong RS. Unicentric Castleman disease. Hematol Oncol Clin North Am. 2018; 32: 65–73.
Németh T, Pécsy B, Géczi T, et al. Successful multidisciplinary management of tetraplegia with a thoracic operation. Unicentric, mediastinal Castleman disease. [Tetraplegia sikeres multidiszciplináris kezelése mellkassebészeti műtéttel. Unicentrikus mediastinalis Castleman-betegség esete.] Orv Hetil. 2020; 161: 33–38. [Hungarian].
van Rhee F, Voorhees P, Dispenzieri A, et al. International, evidence-based consensus treatment guidelines for idiopathic multicentric Castleman disease. Blood 2018; 132: 2115–2124.
Madan R, Chen JH, Trotman-Dickenson B, et al. The spectrum of Castleman’s disease: mimics, radiologic pathologic correlation and role of imaging in patient management. Eur J Radiol. 2012; 81: 123–131.
Abramson JS. Diagnosis and management of Castleman disease. J Natl Compr Canc Netw. 2019; 17: 1417–1419.
Van Rhee F, Oksenhendler E, Srkalovic G, et al. International evidence-based consensus diagnostic and treatment guidelines for unicentric Castleman disease. Blood Adv. 2020; 4: 6039–6050.
Tokunaga T, Kadota Y, Utsumi T, et al. Castleman’s disease arising from an intrapulmonary lymph node. Gen Thorac Cardiovasc Surg. 2009; 57: 562–565.
Gunluoglu G, Olcmen A, Sokucu SN, et al. Intrapulmonary-located Castleman’s disease, which was surgically resected without pulmonary resection. Ann Thorac Cardiovasc Surg. 2011; 17: 580–583.
Ota H, Kawai H, Matsuo T. Unicentric Castleman’s disease arising from an intrapulmonary lymph node. Case Rep Surg. 2013; 2013: 289089.
Racil H, Cheikh Rouhou S, Ismail O, et al. Castleman’s disease: an intrapulmonary form with intrafissural development. Sci World J. 2009; 9: 940–945.
Wang SH, Ruan Z, Huang HL, et al. A rare case of Castleman disease presenting as pulmonary mass mimicking central pulmonary malignancy. Chin Med J (Engl). 2009; 122: 990–991.
Nadir A, Colak N, Koktener A, et al. Isolated intrapulmonary Castleman’s disease: a case report, review of the literature. Ann Thorac Cardiovasc Surg. 2014; 20(Suppl): 689–691.
Yeh CM, Chou CM, Wong LC. Castleman’s disease mimicking intrapulmonary malignancy. Ann Thorac Surg. 2007; 84: e6–e7.
Rawashdeh B, Meyer M, Yimin D, Unicentric Castleman’s disease presenting as a pulmonary mass: a diagnostic dilemma. Am J Case Rep. 2015; 16: 259–261.
Haager B, Kayser G, Schmid S, et al. Intrapulmonary Castleman’s disease pretending to be a lung cancer-work up of an intrapulmonary tumour. Ann Thorac Cardiovasc Surg. 2016; 22: 258–260.
Bacha S, Zribi H, Habibech S, et al. Unicentric Castleman’s disease: an uncommon cause of chronic cough. Tunis Med. 2018; 96: 148–151.
Aoki M, Kamimura G, Umehara T, et al. Tumor enucleation for Castleman’s disease in the pulmonary hilum: a case report. Surg Case Rep. 2019; 5: 95.
Kara M, Ozkan B, Ulker M, et al. Intrapericardial pneumonectomy for unicentric hilar castleman disease. Acta Chir Belg. 2021; 121: 441–444.
Shoji F, Takase K, Kozuma Y, et al. Induction immunotherapy followed by surgery for hilar unicentric Castleman disease. Thor Cancer 2022; 13: 1722–1725.
Mohanna S, Sanchez J, Ferrufino JC, et al. Characteristics of Castleman’s disease in Peru. Eur J Intern Med. 2006; 17: 170–174.
Koa B, Borja AJ, Aly M, et al. Emerging role of 18F-FDG PET/CT in Castleman disease: a review. Insights Imaging 2021; 12: 35.