Zsolt Spitzmüller University of Debrecen, Debrecen, Hungary

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Márton Hajdú University of Debrecen, Debrecen, Hungary

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István Pócsi University of Debrecen, Debrecen, Hungary

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Tamás Emri University of Debrecen, Debrecen, Hungary

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Relative transcriptions of Aspergillus nidulans dug1-3 (orthologes of Saccharomyces cerevisiae DUG — deficient in utilization of glutathione — pathway genes) and ggtA encoding γ-glutamyl transpeptidase were studied under conditions inducing glutathione degradation. GgtA was induced in all cases when glutathione levels decreased, but addition of yeast extract, which moderated glutathione degradation, enhanced its induction. Although dug2 showed constitutive transcription, dug1 and dug3 were induced by carbon and nitrogen starvation and yeast extract did not caused significant changes in their relative transcription. The in silico reconstructed DUG pathway of A. nidulans is a promising candidate for cytosolic GSH degradation induced by carbon/nitrogen stress.

  • 1.

    Adamis, P. D., Mannarino, S. C., Eleutherio, E. C. (2009) Glutathione and gamma-glutamyl transferases are involved in the formation of cadmium-glutathione complex. FEBS Lett. 583, 14891492.

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    Bello, M. H., Morin, D., Epstein, L. (2013) γ-Glutamyltransferases (GGT) in Colletotrichum graminicola: mRNA and enzyme activity, and evidence that CgGGT1 allows glutathione utilization during nitrogen deficiency. Fungal Genet. Biol. 51, 7283.

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    Heisterkamp, N., Groffen, J., Warburton, D., Sneddon, T. P. (2008) The human gamma-glutamyltransferase gene family. Hum. Genet. 123, 321332.

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    Kaur, H., Ganguli, D., Bachhawat, A. K. (2012) Glutathione degradation by the alternative pathway (DUG pathway) in Saccharomyces cerevisiae is initiated by (Dug2p-Dug3p)2 complex, a novel glutamine amidotransferase (GATase) enzyme acting on glutathione. J. Biol. Chem. 287, 89208931.

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    Kimura, K., Tran, L. S., Uchida, I., Itoh, Y. (2004) Characterization of Bacillus subtilis γ-glutamyltranspeptidase and its involvement in the degradation of capsule poly-gammaglutamate. Microbiol. 150, 41154123.

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    Kumar, A., Tikoo, S., Maity, S., Sengupta, S., Sengupta, S., Kaur, A., Bachhawat, A. K. (2012) Mammalian proapoptotic factor ChaC1 and its homologues function as γ-glutamyl cyclotransferases acting specifically on glutathione. EMBO Rep. 13, 10951101.

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  • 7.

    Ohkama-Ohtsu, N., Oikawa, A., Zhao, P., Xiang, C., Saito, K., Oliver, D. J. (2008) A gamma-glutamyl transpeptidase-independent pathway of glutathione catabolism to glutamate via 5-oxoproline in Arabidopsis. Plant Physiol. 148, 16031613.

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    Pócsi, I., Prade, R. A., Penninckx, M. J. (2004) Glutathione, altruistic metabolite in fungi. Adv.Microb. Physiol. 49, 176.

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  • 10.

    Szilágyi, M., Miskei, M., Karányi, Z., Lenkey, B., Pócsi, I., Emri, T. (2013) Transcriptome changes initiated by carbon starvation in Aspergillus nidulans. Microbiology 159, 176190.

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Editorial Board

    1. Csányi, Vilmos (Göd)
    1. Dudits, Dénes (Szeged)
    1. Falus, András (Budapest)
    1. Fischer, Ernő (Pécs)
    1. Gábriel, Róbert (Pécs)
    1. Gulya, Károly (Szeged)
    1. Gulyás, Balázs (Stockholm)
    1. Hajós, Ferenc (Budapest)
    1. Hámori, József (Budapest)
    1. Heszky, László (Gödöllő)
    1. Hideg, Éva (Szeged)
    1. E. Ito (Sanuki)
    1. Janda, Tibor (Martonvásár)
    1. Kavanaugh, Michael P. (Missoula)
    1. Kása, Péter (Szeged)
    1. Klein, Éva (Stockholm)
    1. Kovács, János (Budapest)
    1. Brigitte Mauch-Mani (Neuchâtel)
    1. Nässel, Dick R. (Stockholm)
    1. Nemcsók, János (Szeged)
    1. Péczely, Péter (Gödöllő)
    1. Roberts, D. F. (Newcastle-upon-Tyne)
    1. Sakharov, Dimitri A. (Moscow)
    1. Singh, Meharvan (Fort Worth)
    1. Sipiczky, Mátyás (Debrecen)
    1. Szeberényi, József (Pécs)
    1. Székely, György (Debrecen)
    1. Tari, Irma (Szeged)
    1. Vágvölgyi, Csaba (Szeged),
    1. L. Zaborszky (Newark)


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Acta Biologica Hungarica
Language English
Year of
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Founder Magyar Tudományos Akadémia
H-1051 Budapest, Hungary, Széchenyi István tér 9.
Publisher Akadémiai Kiadó
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Chief Executive Officer, Akadémiai Kiadó
ISSN 0236-5383 (Print)
ISSN 1588-256X (Online)