Authors:
, , , , , , , , , and
Authors:
,
,
,
, and
Zofia Goc
Zofia Goc
Pedagogical University of Cracow, Podbrzezie 3, 31-054 Cracow, Poland
Search for other papers by Zofia Goc in
Current site
Google Scholar
PubMed
Search for other papers by Zofia Goc in
Current site
Google Scholar
PubMed
Agnieszka Greń
Agnieszka Greń
Pedagogical University of Cracow, Podbrzezie 3, 31-054 Cracow, Poland
Search for other papers by Agnieszka Greń in
Current site
Google Scholar
PubMed
Search for other papers by Agnieszka Greń in
Current site
Google Scholar
PubMed
Edyta Kapusta
Edyta Kapusta
Pedagogical University of Cracow, Podbrzezie 3, 31-054 Cracow, Poland
Search for other papers by Edyta Kapusta in
Current site
Google Scholar
PubMed
Search for other papers by Edyta Kapusta in
Current site
Google Scholar
PubMed
Karol Dziubek
Karol Dziubek
Pedagogical University of Cracow, Podbrzezie 3, 31-054 Cracow, Poland
Search for other papers by Karol Dziubek in
Current site
Google Scholar
PubMed
Search for other papers by Karol Dziubek in
Current site
Google Scholar
PubMed
Waldemar Szaroma
Waldemar Szaroma
Pedagogical University of Cracow, Podbrzezie 3, 31-054 Cracow, Poland
Search for other papers by Waldemar Szaroma in
Current site
Google Scholar
PubMed
Search for other papers by Waldemar Szaroma in
Current site
Google Scholar
PubMed
This study investigated the role of exogenous α-lipoic acid (ALA) in the inflammation caused by zymosan application. Seventy-two adult male white mice were divided into twelve groups: three control groups, three Zymosan groups, three ALA groups and three groups being the combination of Zymosan and ALA. In the experimental groups, the animals were decapitated after 3, 6 and 24 hours after the injection. The activity of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) were determined in the brain, liver and kidneys of the mice. After the injection of Zymosan, it was found that the activity of SOD, CAT and GSH-Px in the brain, liver and kidneys of mice was significantly lower in all time periods. The administration of ALA resulted in an opposite effect, namely, it increased the activity of the enzymes studied in the selected organs of mice. The Zymosan and ALA combination significantly inhibited the decrease in the activity of the enzymes compared with the values obtained in the groups of animals which received Zymosan only. The results of our study, using the Zymosan-induced inflammation, clearly indicate that ALA is an anti-inflammatory agent.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Aebi, H. E. (1984) Catalase. In: Bergmeyer, H. U. (ed.) Methods of Enzymatic Analysis. Vol. 3. Wiley, New York, pp. 273–286.
-
2.
Akpinar, D., Yargiçoğlu, P., Derin, N., Alicigüzel, Y., Ağar, A. (2008) The effect of lipoic acid on antioxidant status and lipid peroxidation in rats exposed to chronic restraint stress. Physiol. Res. 57, 893–901.
-
3.
Antczak, A., Nomak, D., Shariati, B., Król, M., Piasecka, G., Kurmanowska, Z. (1997) Increased hydrogen peroxide and thiobarbituric acid reactive products in expired breath condensate of asthmatic patients. Eur. Respir. J. 10, 1235–1241.
-
4.
Biewenga, G. P., Haenen, G. R., Bast, A. (1997) The pharmacology of the antioxidant lipoic acid. Gen. Pharmacol. 29, 315–331.
-
5.
Bradford, M. M. (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle for protein-dye binding. Anal Biochem. 72, 248–254.
-
6.
Bustamante, J., Lodge, J. K., Marcocci, L., Tritschler, H. J., Packer, L., Rihn, B. H. (1998) Alphalipoic acid in liver metabolism and disease. Free Rad. Biol. Med. 24, 1023–1039.
-
7.
Butterfield, A. D., Reed, T., Newman, S. F., Sultana, R. (2007) Roles of amyloid β-peptide-associated oxidative stress and brain protein modifications in the pathogenesis of Alzheimer’s disease and mild cognitive impairment. Free Rad. Biol. Med. 43, 658–677.
-
8.
Chen, P., Ma, Q. G., Ji, C., Zhang, J. Y., Zhao, L. H., Zhang, Y., Jie, Y. (2011) Dietary lipoic acid influences antioxidant capability and oxidative status of broilers. Int. J. Mol. Sci. 12, 8476–8488.
-
9.
Cho, Y. S., Lee, J., Lee, T. H., Lee, K. U., Park, J. Y., Moon, H. B. (2002) Alpha-lipoic acid inhibits airway inflammation and hyperresponsiveness in a mouse model of asthma. J. Allergy Clin. Immunol. 114, 429–435.
-
10.
Crowford, M. A. (1993) The role of essential fatty acids in neural development implications for prenatal nutrition. Am. J. Clin. Nutr. 57 (Suppl), 703–710.
-
11.
Dimitrova, P., Gyurkovska, V., Shalova, I., Saso, L., Ivanovska, N. (2009) Inhibition of zymosaninduced kidney dysfunction by tyrphostin AG-490. J. Inflamm. (Lond.) 6:13. doi: 10.1186/1476-9255-6-13.
-
12.
Dulundu, E., Ozel, Y., Topaloglu, U., Sehirli, O., Ercan, F., Gedik, N., Sener, G. (2007) Alpha-lipopic acid protects against hepatic ischemia-reperfusion injury in rats. Pharmacology 79, 163–170.
-
13.
Emelyanov, A., Fedoseev, G., Abulimity, A., Rudinski, K., Fedoulov, A., Karabanov, A., Barnes, P. J. (2001) Elevated concentrations of exhaled hydrogen peroxide in asthmatic patients. Chest 120, 1136–1139.
-
14.
Feng, B., Yan, X. F., Xue, J. L., Xu, L., Wang, H. (2013) The protective effects of alpha-lipoic acid on kidneys in type 2 diabetic goto-kakisaki rats via reducing oxidative stress. Int. J. Mol. Sci. 14, 6746–6756.
-
15.
Foloyd, R. A., West, M., Hensley, K. (2001) Oxidative biochemical markers; clues to understanding aging in long-lived species. Exp. Gerontol. 36, 619–640.
-
16.
Hagen, T. M., Ingersoll, R. T., Lykkesfeldt, J., Liu, J., Wehr, C. M., Vinarsky, V., Bartholomew, J. C., Ames, A. B. (1999) (R)-alpha-lipoic acid-supplemented old rats have improved mitochondrial function, decreased oxidative damage, and increased metabolic rate. FASEB J. 13, 411–418.
-
17.
Han, D., Sen, C. K., Roy, S., Kobayashi, M. S., Tritschler, H. J., Packer, L. (1997) Protection against glutamate-induced cytotoxicity in C6 glial cells by thiol antioxidants. Am. J. Physiol. 273, R1771–R1778.
-
18.
Han, D., Tritschler, H. J., Packer, L. (1995) α-Lipoic acid increases intracellular glutathione in a human T-lymphocyte Jurkat cell line. Biochem. Biophys. Res. Commun. 207, 258–264.
-
19.
Impellizzeri, D., Mazzon, E., Di Paola, R., Paterniti, I., Baramanti, P., Cuzzocrea, S. (2011) Effect of NADPH-oxidase inhibitors in the experimental model of zymosan-induced shock in mice. FreeRadic. Res. 45, 820–834.
-
20.
Jansen, M. J., Hendriks, T., Verhofstad, A. A., Lange, W., Geeraedts, L. M., Jr., Goris, R. J. (1997) Gradual development of organ damage in the murine zymosan-induced multiple organ dysfunction syndrome. Shock 8, 261–267.
-
21.
Janssen-Heininger, Y. M., Mossman, B. T., Heintz, N. H., Forman, H. J., Kalyanaraman, B., Finkel, T., Stamler, J. S., Rhee, S. G., van der Vliet, A. (2008) Redox-based regulation of signal transduction: principles, pitfalls, and promises. Free Radic. Biol. Med. 45, 1–17.
-
22.
Kagan, V. E., Shvedova, A., Serbinova, E., Khan, S., Swanson, C., Powell, R., Packer, L. (1992) Dihydrolipoic – a universal antioxidant both in the membrane and in the aqueous phase. Reduction of peroxyl, ascorbyl and chromanoxyl radicals. Biochem. Pharmacol. 44, 1637–1649.
-
23.
Kitada, M., Kume, S., Imaizumi, N., Koya, D. (2011) Resveratrol improves oxidative stress and protects against diabetic nephropathy through normalization of Mn-SOD dysfunction in AMPK/SIRT1-independent pathway. Diabetes 60, 634–643.
-
24.
Kubo, K., Saito, M., Tadocoro, T., Maekawa, A. (1997) Changes in susceptibility of tissues to lipid peroxidation after ingestion of various levels of docosahexanoic acid and vitamin E. Br. J. Nutr. 78, 655–669.
-
25.
Le Bras, M., Clément, M. V., Pervaiz, S., Brenner, C. (2005) Reactive oxygen species and the mitochondrial signaling pathway of cell death. Histol. Histopathol. 20, 205–219.
-
26.
Li, C., Zhou, H. M. (2011) The role of manganese superoxide dismutase in inflammation defense. Enzyme Res. 2011, 387176. doi: 10.4061/2011/387176.
-
27.
Li, H., Gonnella, P., Safavi, F., Vessal, G., Nourbakhsh, B., Zhou, F., Zhang, G. X., Rostami, A. (2013) Low dose zymosan ameliorates both chronic and relapsing experimental autoimmune encephalomyelitis. J. Neuroimmunol. 254, 28–38.
-
28.
Liang, H., Ran, Q., Jang, Y. C., Holstein, D., Lechleiter, J., McDonald-Marsh, T., Musatov, A., Song, W., Van Remmen, H., Richardson, A. (2009) Glutathione peroxidase 4 differentially regulates the release of apoptogenic proteins from mitochondria. Free Radic. Biol. Med. 47, 312–320.
-
29.
Lück, H. (1962) Peroxidase. In: Bergmeyer, H. U. (ed.) Methoden der enzymatischen Analyse. Verlag Chemie GmbH, Weinheim, pp. 895–897.
-
30.
Moini, H., Packer, L., Saris, N. E. (2002) Antioxidant and prooxidant activities of alpha-lipoic acid and dihydrolipoic acid. Toxicol. Appl. Pharmacol. 182, 84–90.
-
31.
Mruk, D. D., Silvestrini, B., Mo, M. Y., Cheng, C. Y. (2002) Antioxidant superoxide dismutase–a review: its function, regulation in the testis, and role in male fertility. Contraception 65, 305–311.
-
32.
Odabasoglu, F., Halici, Z., Aygun, H., Halici, M., Atalay, F., Cakir, A., Cadirci, E., Bayir, Y., Suleyman, H. (2011) α-Lipoic acid has anti-inflammatory and anti-oxidative properties: an experimental study in rats with carrageenan-induced acute and cotton pellet-induced chronic inflammations. Br. J. Nutr. 105, 31–43.
-
33.
Packer, L., Kraemer, K., Rimbach, G. (2001) Molecular aspects of lipoic acid in the prevention of diabetes complications. Nutrition 17, 888–895.
-
34.
Pillai, C. K., Pillai, K. S. (2002) Antioxidants in health. Indian J. Physiol. Pharmacol. 46, 1–5.
-
35.
Pini, M., Gove, M. E., Senello, J. A., van Baal, J. W. P. M., Chan, L., Fantuzzi, G. (2008) Role and regulation of adipokines during zymosan-induced peritoneal inflammation in mice. Endocrinology149, 4080–4085.
-
36.
Podda, M., Tritschler, H. J., Ulrich, H., Packer, L. (1994) Alpha-lipoic acid supplementation prevents symptoms of vitamin E deficiency. Biochem. Biophys. Res. Commun. 14, 98–104.
-
37.
Rice-Evans, C. A., Diplock, A. T., Symons, M. C. R. (1991) Techniques in free radicals research. In: Burdon, R. H., van Knippenberg, P. H. (eds) Laboratory Techniques in Biochemistry and MolecularBiology. Elsevier, Amsterdam, London, New York, Tokyo.
-
38.
Sahach, V. F., Kakhanovs’kyŭ, E. F., Horbovets, V. S. (2008) The mitochondrial permeability transition pore opening under oxidative stress in ischemia/reperfusion in the tissue of the lower extremities. Fiziol. Zh. 54, 47–51.
-
39.
Santos, R. C., Moresco, R. N., Peña Rico, M. A., Susperregui, A. R., Rosa, J. L., Bartrons, R., Ventura, F., Mário, D. N., Alves, S. H., Tatsch, E., Kober, H., de Mello, R. O., Scherer, P., de Oliveira, J. R. (2012) Fructose-1, 6-bisphosphate protects against zymosan-induced acute lung injury in mice. Inflammation 35, 1198–1203.
-
40.
Selvakumar, E., Prahalathan, C., Mythili, Y., Varalakshmi, P. (2005) Beneficial effects of DL-α-lipoic acid on cyclophosphamide-induced oxidative stress in mitochondrial fractions of rat testis. Chem.Biol. Interact. 152, 59–66.
-
41.
Sen, C. K. (1997) Nutritional biochemistry of cellular glutathione. J. Nutr. Biochem. 8, 660–672.
-
42.
Smith, A. R., Shenvi, S. V., Widlansky, M., Suh, J. H., Hagen, T. M. (2004) Lipoic acid as a potential therapy for chronic diseases associated with oxidative stress. Curr. Med. Chem. 11, 1135–1146.
-
43.
Szaroma, W., Dziubek, K. (2011) Changes in the amount of reduced glutathione and activity of antioxidant enzymes in chosen mouse organs influenced by zymosan and melatonin administration. ActaBiol. Hung. 62, 133–141.
-
44.
Takenaka, M., Kanada, S., Hamazaki, T., Watanabe, S. (2005) Dietary supplementation with n-3 polyunsaturated fatty acids attenuates the depression of food-motivated behavior during zymosaninduced peritonitis. Biol. Pharm. Bull. 28, 1291–1293.
-
45.
Zygmunt, M., Dudek, M., Bilska-Wilkosz, A., Bednarski, M., Mogilski, Sz., Knutelska, J., Sapa, J. (2013) Anti-inflammatory activity of lipoic acid in mice peritonitis model. Acta Pol. Pharm. 70, 899–904.
Acta Biologica Hungarica
P.O. Box 35
H-8237 Tihany, Hungary
Phone: (36 87) 448 244 ext. 103
Fax: (36 87) 448 006
E-mail: elekes@tres.blki.hu
Indexing and Abstracting Services:
- Biological Abstracts
- BIOSIS Previews
- CAB Abstracts
- Chemical Abstracts
- Current Contents: Agriculture
- Biology and Environmental Sciences
- Elsevier BIOBASE
- Global Health
- Index Medicus
- Index Veterinarius
- Medline
- Referativnyi Zhurnal
- Science Citation Index
- Science Citation Index Expanded (SciSearch)
- SCOPUS
- The ISI Alerting Services
- Zoological Abstracts
| Acta Biologica Hungarica | |
|---|---|
| Language | English |
| Size | |
| Year of Foundation |
1950 |
| Publication Programme |
changed title |
| Volumes per Year |
|
| Issues per Year |
|
| Founder | Magyar Tudományos Akadémia |
| Founder's Address |
H-1051 Budapest, Hungary, Széchenyi István tér 9. |
| Publisher | Akadémiai Kiadó |
| Publisher's Address |
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245. |
| Responsible Publisher |
Chief Executive Officer, Akadémiai Kiadó |
| ISSN | 0236-5383 (Print) |
| ISSN | 1588-256X (Online) |
Monthly Content Usage
| Abstract Views | Full Text Views | PDF Downloads | |
|---|---|---|---|
| Mar 2024 | 23 | 0 | 0 |
| Apr 2024 | 30 | 0 | 0 |
| May 2024 | 24 | 0 | 0 |
| Jun 2024 | 30 | 0 | 0 |
| Jul 2024 | 47 | 0 | 0 |
| Aug 2024 | 36 | 0 | 0 |
| Sep 2024 | 1 | 0 | 0 |
Authors:
, , , , and
Authors:
, , , , , , and
Copyright Akadémiai Kiadó AKJournals is the trademark of Akadémiai Kiadó's journal publishing business branch.
Powered by PubFactory