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Oana Roşca-Casian “Babeş-Bolyai” University, 42 Republicii Street, 400015 Cluj-Napoca, Romania

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Cristina Mircea “Babeş-Bolyai” University, 42 Republicii Street, 400015 Cluj-Napoca, Romania

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Laurian Vlase “Iuliu Haţieganu” University of Medicine and Pharmacy, 12 Ion Creangă Street, 400010 Cluj-Napoca, Romania

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Ana-Maria Gheldiu “Iuliu Haţieganu” University of Medicine and Pharmacy, 12 Ion Creangă Street, 400010 Cluj-Napoca, Romania

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Delia Tania Teuca “Babeş-Bolyai” University, 42 Republicii Street, 400015 Cluj-Napoca, Romania

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Marcel Pârvu “Babeş-Bolyai” University, 42 Republicii Street, 400015 Cluj-Napoca, Romania

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The 50% ethanol extract obtained from Hedera helix leaves was investigated regarding the presence and quantity of polyphenols, sterols and in vitro antifungal activity against phytopathogenic fungi. The chemical analysis revealed the presence of rutin, quercetin and kaempferol in the non-hydrolysed sample and quercetin and kaempferol in the hydrolysed sample and stigmasterol in the ivy leaf extract (nonhydrolysed sample). The antifungal activity against phytopathogenic fungi (Aspergillus niger, Botrytis cinerea, B. tulipae, Fusarium oxysporum f. sp. tulipae, Penicillium gladioli, and Sclerotinia sclerotiorum) was assessed using an agar dilution assay. The results are expressed as the minimum inhibitory concentration (MIC = 10–14%) and were compared to a synthetic antifungal drug – fluconazole (MIC = 8–30%). This report presents the first screening of the antifungal activity of the ivy leaf extract on these plant pathogenic fungi species, aiming to use the ivy leaf extract for controlling different diseases of vegetables and ornamental plants, in addition to human disorders.

  • 1.

    Akinboye, E. S., Bakare, O. (2011) Biological activities of emetine. Open Nat. Prod. J. 4, 815.

  • 2.

    Baysal, O., Zeller, W. (2004) Extract of Hedera helix induces resistance on apple rootstock M26 similar to Acibenzolar-S-methyl against fire blight (Erwinia amylovora). Physiol. Mol. Plant P. 65, 305315.

    • Search Google Scholar
    • Export Citation
  • 3.

    Buchwald, W., Mordalski, R., Kucharski, W. A., Gryszczyńska, A., Adamczak, A. (2015) Effect of fertilization on roseroot (Rhodiola rosea L.) yield and content of active compounds. Acta Sci. Pol. Hortorum Cultus 14, 109121.

    • Search Google Scholar
    • Export Citation
  • 4.

    Cwientzek, U., Ottillinger, B., Arenberger, P. (2011) Acute bronchitis therapy with ivy leaves extracts in a two-arm study. A double-blind, randomised study vs. another ivy leaves extract. Phytomedicine 18, 11051109.

    • Search Google Scholar
    • Export Citation
  • 5.

    Deliorman Orhan, D., Özçelik, B., Hosbas, S., Vural, M. (2012) Assessment of antioxidant, antibacterial, antimycobacterial, and antifungal activities of some plants used as folk remedies in Turkey against dermatophytes and yeast-like fungi. Turk. J. Biol. 36, 672686.

    • Search Google Scholar
    • Export Citation
  • 6.

    Demirci, B., Goppel, M., Demirci, F., Franz, G. (2004) HPLC profiling and quantification of active principles in leaves of Hedera helix L. Pharmazie 59, 770774.

    • Search Google Scholar
    • Export Citation
  • 7.

    Dumitriu, B., Olariu, L., Nita, R., Zglimbea, L., Rosoiu, N. (2013) Vascular anti-inflammatory effects of natural compounds from Aesculus hippocastanum and Hedera helix. Rom. Biotech. Lett. 18, 79637974.

    • Search Google Scholar
    • Export Citation
  • 8.

    Eguale, T., Tilahun, G., Debella, A., Feleke, A., Makonnen, E. (2007) Haemonchus contortus: In vitro and in vivo anthelmintic activity of aqueous and hydro-alcoholic extracts of Hedera helix. Exp. Parasitol. 116, 340345.

    • Search Google Scholar
    • Export Citation
  • 9.

    Elias, R., Diaz Lanza, A. M., Vidal-Ollivier, E., Balansard, G., Faure, R., Babadjamian, A. (1991) Triterpenoid saponins from the leaves of Hedera helix. J. Nat. Prod. 54, 98103.

    • Search Google Scholar
    • Export Citation
  • 10.

    Ferrara, L., Naviglio, D., Faralli, S. (2013) Identification of active principles of Hedera helix L. in aqueous extracts. J. Phytochem. Photon. 114, 170175.

    • Search Google Scholar
    • Export Citation
  • 11.

    Fodorea, C. S., Vlase, L., Leucuta, S. E., Tamas, M. (2005) Phytochemical study on some polyphenols of Geranium pyrenaicum. Chem. Nat. Compd. 41, 400403.

    • Search Google Scholar
    • Export Citation
  • 12.

    Gepdiremen, A., Mshvildadze, V., Süleyman, H., Elias, R. (2005) Acute anti-inflammatory activity of four saponins isolated from ivy: Alpha-hederin, hederasaponin-C, hederacolchiside-E and hederacolchiside-F in carrageenan-induced rat paw edema. Phytomedicine 12, 440444.

    • Search Google Scholar
    • Export Citation
  • 13.

    Gruenwald, J., Brendler, T., Jaenicke, C. (2000) PDR for Herbal Medicines. Medical Economics Company, Montvale.

  • 14.

    Gülçin, I., Mshvildadze, V., Gepdiremen, A., Elias, R. (2004) Antioxidant activity of saponins isolated from ivy: a-Hederin, hederasaponin-C, hederacolchiside-E and hederacolchiside-F. Planta Med. 70, 561563.

    • Search Google Scholar
    • Export Citation
  • 15.

    Han, G. R., Wang, Y. F., Feng, S. H., Jia, Y. X. (2013) Simultaneous determination of cephaeline and emetine in ipecac and its preparations using RP-HPLC. Chinese Herb. Med. 5, 286291.

    • Search Google Scholar
    • Export Citation
  • 16.

    Lutsenko, Y., Bylka, W., Matlawska, I., Darmohray, R. (2010) Hedera helix as a medicinal plant. Herba Pol. 56, 8396.

  • 17.

    Mahran, G. H., Hilal, S. H., El-Alfy, T. S. (1975) The isolation and characterization of emetine alkaloid from Hedera helix. Planta Med. 27, 127132.

    • Search Google Scholar
    • Export Citation
  • 18.

    Majester-Savornin, B., Elias, R., Diaz-Lanza, A. M., Balansard, G., Gasquet, M., Delmas, F. (1991) Saponins of the ivy plant, Hedera helix, and their leishmanicidic activity. Planta Med. 57, 260262.

    • Search Google Scholar
    • Export Citation
  • 19.

    Mandade, R. J., Choudhuri, A., Mashirkar, V., Sakarkar, D. (2010) Analgesic and anti-inflammatory activities of Hedera helix leaf extract. Pharmacie Globale (Int. J. Comprehen. Pharm.), 1, 13.

    • Search Google Scholar
    • Export Citation
  • 20.

    Medeiros, J. R., Medeiros, H., Mascarenhas, C., Davin, L. B., Lewis, N. G. (2002) Bioactive components of Hedera helix. Arquipél., Life Mar. Sci. 19A, 2732.

    • Search Google Scholar
    • Export Citation
  • 21.

    Nidiry, E. S. J., Babu, C. S. B. (2005) Antifungal activity of tuberose absolute and some of its constituents. Phytother. Res. 19, 447449.

    • Search Google Scholar
    • Export Citation
  • 22.

    Pârvu, M., Vlase, L., Fodorpataki, L., Pârvu, O., Rosca-Casian, O., Bartha, C., Barbu-Tudoran, L., Pârvu, A. E. (2013) Chemical composition of celandine (Chelidonium majus L.) extract and its effects on Botrytis tulipae (Lib.) Lind fungus and the tulip. Not. Bot. Hort. Agrobot. Cluj-Napoca, 41, 414426.

    • Search Google Scholar
    • Export Citation
  • 23.

    Pârvu, M., Vlase, L., Pârvu, A.-E., Rosca-Casian, O., Gheldiu, A.-M., Pârvu, O. (2015) Phenolic compounds and antifungal activity of Hedera helix L. (ivy) flowers and fruits. Not. Bot. Hort. Agrobot. Cluj-Napoca 43, 5358.

    • Search Google Scholar
    • Export Citation
  • 24.

    Peev, C. I., Vlase, L., Antal, D. S., Dehelean, C. A., Szabadai, Z. (2007) Determination of some polyphenolic compounds in buds of Alnus and Corylus species by HPLC. Chem. Nat. Compd. 43, 259262.

    • Search Google Scholar
    • Export Citation
  • 25.

    Rai, A. (2011) The effects of alcoholic Hedera helix plant extract on Ehrlich ascitic tumour cells in vitro and its antitumour activities in vivo. Int. J. Pharm. Sci. Rev. Res. 11, 4750.

    • Search Google Scholar
    • Export Citation
  • 26.

    Rai, A. (2013) The antiinflammatory and antiarthritic properties of ethanol extract of Hedera helix. Indian J. Pharm. Sci. 75, 99102.

    • Search Google Scholar
    • Export Citation
  • 27.

    Röhner, E., Carabet, A., Buchenauer, H. (2004) Effectiveness of plant extracts of Paeonia suffruticosa and Hedera helix against diseases caused by Phytophthora infestans in tomato and Pseudoperonospora cubensis in cucumber. J. Plant Dis. Prot. 111, 8395.

    • Search Google Scholar
    • Export Citation
  • 28.

    Schmidt, M., Thomsen, M., Schmidt, U. (2012) Suitability of ivy extract for the treatment of paediatric cough. Phytother. Res. 26, 19421947.

    • Search Google Scholar
    • Export Citation
  • 29.

    Stauss-Crabo, M., Atiye, S. (2009) Ivy, a traditionally used medicinal plant in modern phytotherapy (Review). Z. Phytother. 30, 289291.

    • Search Google Scholar
    • Export Citation
  • 30.

    Sundaram, U., Gurumoorthi, P. (2012) Validation of HPTLC method for quantitative estimation of L-Dopa from Mucuna pruriens. Int. Res. J. Pharm. 3, 300304.

    • Search Google Scholar
    • Export Citation
  • 31.

    Sesan, T. E., Enache, E., Iacomi, B. M., Oprea, M., Oancea, F., Iacomi, C. (2015) Antifungal activity of some plant extracts against Botrytis cinerea Pers. in the blackcurrant crop (Ribes nigrum L.). Acta Sci. Pol., Hortorum Cultus 14, 2943.

    • Search Google Scholar
    • Export Citation
  • 32.

    Trute, A., Nahrstedt, A. (1997) Identification and quantitative analysis of phenolic compounds from the dry extract of Hedera helix. Planta Medica 63, 177179.

    • Search Google Scholar
    • Export Citation
  • 33.

    Uddin, G., Rauf, A., Qaisar, M., Rehman, T. U., Latif, A., Ali, M. (2011) Preliminary phytochemical screening and antimicrobial activity of Hedera helix L. Middle-East J. Sci. Res. 8, 198202.

    • Search Google Scholar
    • Export Citation
  • 34.

    Villani, P., Orsière, T., Sari-Minodier, I., Bouvenot, G., Botta, A. (2001) Antimutagenic effects of alphahederin in vitro. Ann. Biol. Clin. 59, 285289.

    • Search Google Scholar
    • Export Citation
  • 35.

    Vlase, L., Pârvu, M., Pârvu, E. A., Toiu, A. (2013) Chemical constituents of three Allium species from Romania. Molecules 18, 114127.

    • Search Google Scholar
    • Export Citation
  • 36.

    Zafar, I., Mohammad, P., Asadullah Muhammad, I., Bashir, A., Shahida, Z., Saima, G. (2002) Study of the hypoglycemic activity of Hedera helix L. in alloxan-induced diabetic rabbits. J. Med. Sci. 2, 206208.

    • Search Google Scholar
    • Export Citation
  • 37.

    www.ema.europa.eu. European Medicines Agency. (2012) Assessment report on Hedera helix L. folium.

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Editorial Board

    1. Csányi, Vilmos (Göd)
    1. Dudits, Dénes (Szeged)
    1. Falus, András (Budapest)
    1. Fischer, Ernő (Pécs)
    1. Gábriel, Róbert (Pécs)
    1. Gulya, Károly (Szeged)
    1. Gulyás, Balázs (Stockholm)
    1. Hajós, Ferenc (Budapest)
    1. Hámori, József (Budapest)
    1. Heszky, László (Gödöllő)
    1. Hideg, Éva (Szeged)
    1. E. Ito (Sanuki)
    1. Janda, Tibor (Martonvásár)
    1. Kavanaugh, Michael P. (Missoula)
    1. Kása, Péter (Szeged)
    1. Klein, Éva (Stockholm)
    1. Kovács, János (Budapest)
    1. Brigitte Mauch-Mani (Neuchâtel)
    1. Nässel, Dick R. (Stockholm)
    1. Nemcsók, János (Szeged)
    1. Péczely, Péter (Gödöllő)
    1. Roberts, D. F. (Newcastle-upon-Tyne)
    1. Sakharov, Dimitri A. (Moscow)
    1. Singh, Meharvan (Fort Worth)
    1. Sipiczky, Mátyás (Debrecen)
    1. Szeberényi, József (Pécs)
    1. Székely, György (Debrecen)
    1. Tari, Irma (Szeged)
    1. Vágvölgyi, Csaba (Szeged),
    1. L. Zaborszky (Newark)

 

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Acta Biologica Hungarica
Language English
Size  
Year of
Foundation
1950
Publication
Programme
changed title
Volumes
per Year
 
Issues
per Year
 
Founder Magyar Tudományos Akadémia
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Address
H-1051 Budapest, Hungary, Széchenyi István tér 9.
Publisher Akadémiai Kiadó
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H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
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Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 0236-5383 (Print)
ISSN 1588-256X (Online)