The new Psychotria species belongs to the panamensis-mexiae complex with its large long deciduous ferrugineous terminal stipules, but differs from them by having shorter inflorescence, 2–3 times larger flowers, smaller leaves and less numerous secondary nerves. It is of allopatric distribution being endemic to Jalisco state, while the area of P. mexiae Standl. extends from Veracruz to Costa Rica and the populations of P. panamensis Standl. are found from Veracruz to Colombia.