Authors:
Lidija Mrakovcic Division of Molecular Medicine, Rudjer Boskovic Institute, Zagreb, Croatia
Division of Molecular Medicine, Laboratory for Oxidative Stress, Rudjer Boskovic Institute, Bijenicka 54, Zagreb, Croatia

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Marina Cindric Department of Pathology, School of Medicine, University of Zagreb, University Hospital Centre, Zagreb, Croatia

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Neven Zarkovic Division of Molecular Medicine, Rudjer Boskovic Institute, Zagreb, Croatia

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Suzana Borovic Sunjic Division of Molecular Medicine, Rudjer Boskovic Institute, Zagreb, Croatia

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Andrea Mogus Milankovic Rudjer Boskovic Institute, NMR Center, Zagreb, Croatia

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Renate Wildburger Universitätsklinik für Unfallchirurgie, Medizinische Universität Graz, Graz, Austria

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Abstract

Tissue regeneration is a complex biological process of vital importance since it allows renewal of damaged cells and organs. The healing of long bones and large joints is often extended or incomplete primarily in elderly people or in polytraumatized patients. Various attempts are made to solve this severe medical and social problem by developing novel bioactive materials, among which bioactive glass is the most attractive because of its osteoconductive and osteostimulative properties. Lipid peroxidation is defined as an important parameter of systematic stress response in patients with traumatic brain injuries and bone fractures. The major bioactive marker and final product of lipid peroxidation, 4-hydroxynonenal (HNE), is a particularly interesting biomolecule because it regulates differentiation, proliferation and apoptosis of cells and might therefore play an important role in regulating the regeneration of damaged tissue such as bone. Therefore, in this study, we investigated the concept of using bioactive glass functionalized with HNE as an in vitro model of bone regeneration.

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Clinical and Experimental Medical Journal
Language English
Size  
Year of
Foundation
2007
Publication
Programme
ceased
Volumes
per Year
 
Issues
per Year
 
Publisher Akadémiai Kiadó
Publisher's
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H-1117 Budapest, Hungary 1516 Budapest, PO Box 245
Responsible
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Chief Executive Officer, Akadémiai Kiadó
ISSN 2060-6249 (Print)
ISSN 2060-968X (Online)

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