In this study, it was aimed to investigate the possible protective effect of an ethanolic extract of Basella alba L. on gentamycin (GM)-induced nephrotoxicity in Wistar albino rats. In the toxic group, rats were administered GM only (100 mg/kg, i.p.) for 8 days. In drug treated groups, rats were pretreated with B. alba (250 and 500 mg/kg per day orally) for 14 days and co-treated with GM for 8 days. After 24 h of the last dose, blood, urine, and tissue samples were collected from the animals. GM when administered induced a marked renal failure, characterized by a significant increase in serum and urine creatinine, urea, uric acid, gamma-glutamyl transferase (GGT), and protein levels. Besides, there were elevation of malondialdehyde (MDA) level and decrease in the concentration of total proteins (TPs) and free -SH in kidney tissue, which are indicators of oxidative stress of kidney. The extract also significantly reduced the GM-induced elevated serum and urine levels of sodium, potassium, calcium, protein, creatinine, urea, uric acid, and GGT. The tissue MDA level was also significantly diminished; the decreased free -SH and TP levels were significantly replenished by an ethanolic extract of B. alba treatment. The experimental results suggest that B. alba extract protected GM-induced nephrotoxicity, possibly by enhancing renal antioxidant system. The findings suggest the potential therapeutic use of B. alba as a novel nephroprotective agent.
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