Journal of Flow Chemistry
Volume/Issue:
Volume 1: Issue 2
A Continuous-Flow System for Asymmetric Hydrogenation Using Supported Chiral Catalysts
Authors:
József Madarász Department of Organic Chemistry, Institute of Environmental Engineering, University of Pannonia, P. O. Box 158, H-8201, Veszprém, Hungary

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Gergely Farkas Department of Organic Chemistry, Institute of Environmental Engineering, University of Pannonia, P. O. Box 158, H-8201, Veszprém, Hungary

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Szabolcs Balogh Department of Organic Chemistry, Institute of Environmental Engineering, University of Pannonia, P. O. Box 158, H-8201, Veszprém, Hungary

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Áron Szöllősy Department of General and Analytical Chemistry, Budapest University of Technology and Economics, Szent Gellért tér 4, H-1111, Budapest, Hungary

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József Kovács Department of Organic Chemistry, Institute of Environmental Engineering, University of Pannonia, P. O. Box 158, H-8201, Veszprém, Hungary

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Ferenc Darvas ThalesNano Nanotechnology Inc., Záhony u. 7., Graphisoft Park, 1031, Budapest, Hungary

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László Ürge ThalesNano Nanotechnology Inc., Záhony u. 7., Graphisoft Park, 1031, Budapest, Hungary

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József Bakos Department of Organic Chemistry, Institute of Environmental Engineering, University of Pannonia, P. O. Box 158, H-8201, Veszprém, Hungary

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Pages:
62–67
Online Publication Date:
20 Dec 2011
Publication Date:
20 Dec 2011
Article Category:
Review Article
DOI:
https://doi.org/10.1556/jfchem.2011.00002
Keywords:
asymmetric catalysis; continuous-flow system; heterogeneous catalysis; hydrogenation; supported catalysts; rhodium
Restricted access

Abstract

Highly active immobilized hydrogenation catalytic systems were used in the H-Cube™ hydrogenation reactor. “In situ” produced [Rh(COD)((S)-MonoPhos)2]BF4 complex was immobilized on commercially available Al2O3 and mesoporous Al2O3 by means of phosphotungstic acid (PTA), respectively. The optimum reaction conditions were determined and studied at different temperature, pressure, and flow rate values. Furthermore, the effect of the substrate concentration, microstructure of the support, and the stability of the complex were investigated. A continuous-flow reaction system using a stationary-phase catalyst for the asymmetric hydrogenation of methyl acetamidoacrylate was developed and run continuously for 12 h with >99% conversion and 96–97% enantioselectivity.

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Cover Journal of Flow Chemistry
Journal of Flow Chemistry A Journal of the Flow Chemistry Society
Print ISSN:
2062-249X
Online ISSN:
2063-0212

To see the editorial board, please visit the website of Springer Nature.

Manuscript Submission: HERE

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Journal of Flow Chemistry
Language English
Size A4
Year of
Foundation		 2011
Volumes
per Year		 1
Issues
per Year		 4
Founder Áramlásos Kémiai Tudományos Társaság
Founder's
Address		 H-1031 Budapest, Hungary Záhony utca 7.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 2062-249X (Print)
ISSN 2063-0212 (Online)

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