Important Industrial Procedures Revisited in Flow: Very Efficient Oxidation and N-Alkylation Reactions with High Atom-Economy

Gellért Sipos; Viktor Gyollai; Tamás Sipőcz; György Dormán; László Kocsis; Richard V. Jones; Ferenc Darvas

doi:10.1556/jfc-d-12-00025

Journal of Flow Chemistry

Volume/Issue:: Volume 3: Issue 2

Important Industrial Procedures Revisited in Flow: Very Efficient Oxidation and N-Alkylation Reactions with High Atom-Economy

Authors:

Gellért Sipos

Gellért Sipos ThalesNano, Zahony u. 7, 1031, Budapest, Hungary

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Viktor Gyollai

Viktor Gyollai ThalesNano, Zahony u. 7, 1031, Budapest, Hungary

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Tamás Sipőcz

Tamás Sipőcz ThalesNano, Zahony u. 7, 1031, Budapest, Hungary

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György Dormán

György Dormán ThalesNano, Zahony u. 7, 1031, Budapest, Hungary

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László Kocsis

László Kocsis ThalesNano, Zahony u. 7, 1031, Budapest, Hungary

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Richard V. Jones

Richard V. Jones ThalesNano, Zahony u. 7, 1031, Budapest, Hungary

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Ferenc Darvas

Ferenc Darvas ThalesNano, Zahony u. 7, 1031, Budapest, Hungary

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Pages:: 51–58

Online Publication Date:: 19 Jun 2013

Publication Date:: 19 Jun 2013

Article Category:: Research Article

DOI:: https://doi.org/10.1556/jfc-d-12-00025

Keywords:: oxidation; N-alkylation; atom economy; gas–liquid–solid flow reactors; heterogenous catalysts

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Abstract

The atom economy concept is one of the earliest recognition for green and sustainable aspects of organic synthesis. Over the years, novel technologies emerged that made this important feature of reactions into practice. Continuous-flow devices increased the efficiency of the chemical transformations with novel process windows (high T, high p and heterogeneous packed catalysts etc.) and increased safety which turned the attention to reexamine old, industrial processes. Oxidation can be performed under flow catalytic conditions with molecular oxygen; alcohols can be oxidized to carbonyl compounds with high atom economy (AE = 87 %). Using O₂ and 1 % Au/TiO₂, alcohol oxidation in flow was achieved with complete conversion and >90 % yield. N-alkylation is another good example for achieving high atom economy. Under flow catalytic conditions (Raney Ni), amines were successfully reacted with alcohols directly (AE = 91 %) with >90 % conversion and selectivity. In both examples, the effective residence time was less than 1 min. These two examples demonstrate the significant contribution of flow technology to the realization of key principles in green and sustainable chemistry.

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Journal of Flow Chemistry A Journal of the Flow Chemistry Society

Print ISSN:: 2062-249X

Online ISSN:: 2063-0212

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Journal of Flow Chemistry
Language	English
Size	A4
Year of Foundation	2011
Volumes per Year	1
Issues per Year	4
Founder	Áramlásos Kémiai Tudományos Társaság
Founder's Address	H-1031 Budapest, Hungary Záhony utca 7.
Publisher	Akadémiai Kiadó Springer Nature Switzerland AG
Publisher's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245. CH-6330 Cham, Switzerland Gewerbestrasse 11
Responsible Publisher	Chief Executive Officer, Akadémiai Kiadó
ISSN	2062-249X (Print)
ISSN	2063-0212 (Online)