Authors:
Klára Lövei Gedeon Richter Plc., Gyömrői út 19–21, Budapest H-1103, Hungary
Eötvös University, Pázmány Péter stny. 1/a, Budapest H-1117, Hungary

Search for other papers by Klára Lövei in
Current site
Google Scholar
PubMed
Close
,
István Greiner Gedeon Richter Plc., Gyömrői út 19–21, Budapest H-1103, Hungary

Search for other papers by István Greiner in
Current site
Google Scholar
PubMed
Close
,
János Éles Gedeon Richter Plc., Gyömrői út 19–21, Budapest H-1103, Hungary

Search for other papers by János Éles in
Current site
Google Scholar
PubMed
Close
,
Áron Szigetvári Gedeon Richter Plc., Gyömrői út 19–21, Budapest H-1103, Hungary
Department of Organic Chemistry and Technology, Műegyetem rkp. 1-3, Budapest H-1111, Hungary

Search for other papers by Áron Szigetvári in
Current site
Google Scholar
PubMed
Close
,
Miklós Dékány Gedeon Richter Plc., Gyömrői út 19–21, Budapest H-1103, Hungary

Search for other papers by Miklós Dékány in
Current site
Google Scholar
PubMed
Close
,
Sándor Lévai Gedeon Richter Plc., Gyömrői út 19–21, Budapest H-1103, Hungary

Search for other papers by Sándor Lévai in
Current site
Google Scholar
PubMed
Close
,
Zoltán Novák Eötvös University, Pázmány Péter stny. 1/a, Budapest H-1117, Hungary

Search for other papers by Zoltán Novák in
Current site
Google Scholar
PubMed
Close
, and
György István Túrós Gedeon Richter Plc., Gyömrői út 19–21, Budapest H-1103, Hungary

Search for other papers by György István Túrós in
Current site
Google Scholar
PubMed
Close
Restricted access

In medicinal chemistry, the development of synthetic procedures for the access of new heterocyclic systems as potential scaffolds is elementary. Herein, we report our results on the formation of small drug-like heterocycles, utilizing flow chemistry. This approach enables the extension of the reaction parameter window, including high-pressure/high-temperature or hazardous chemistry. In our work, various novel condensed tricyclic benzothiazoles fused with furo- and thieno-rings were synthesized applying a multistep continuous-flow protocol. The process includes two ring closure steps and a nitro group reduction step. Batch and telescoped continuous-flow syntheses were also designed and performed.

Supplementary Materials

    • Supplementary Material
  • Collapse
  • Expand

To see the editorial board, please visit the website of Springer Nature.

Manuscript Submission: HERE

For subscription options, please visit the website of Springer Nature.

Journal of Flow Chemistry
Language English
Size A4
Year of
Foundation
2011
Volumes
per Year
1
Issues
per Year
4
Founder Áramlásos Kémiai Tudományos Társaság
Founder's
Address
H-1031 Budapest, Hungary Záhony utca 7.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 2062-249X (Print)
ISSN 2063-0212 (Online)