Two-Stage Flow Synthesis of Coumarin via O-Acetylation of Salicylaldehyde

Xin Li; Anbang Chen; Yangzhi Zhou; Lingling Huang; Zheng Fang; Haifeng Gan; Kai Guo

doi:10.1556/1846.2014.00043

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Journal of Flow Chemistry

Volume/Issue:: Volume 5: Issue 2

Two-Stage Flow Synthesis of Coumarin via O-Acetylation of Salicylaldehyde

Authors:

Xin Li

Xin Li Nanjing Tech University, 30 Puzhu Rd S., Nanjing 211816, PR China

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Anbang Chen

Anbang Chen Nanjing Tech University, 30 Puzhu Rd S., Nanjing 211816, PR China

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Yangzhi Zhou

Yangzhi Zhou Nanjing Tech University, 30 Puzhu Rd S., Nanjing 211816, PR China

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Lingling Huang

Lingling Huang Nanjing Tech University, 30 Puzhu Rd S., Nanjing 211816, PR China

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Zheng Fang

Zheng Fang Nanjing Tech University, 30 Puzhu Rd S., Nanjing 211816, PR China

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Haifeng Gan

Haifeng Gan Nanjing Tech University, 30 Puzhu Rd S., Nanjing 211816, PR China

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Kai Guo

Kai Guo Nanjing Tech University, 30 Puzhu Rd S., Nanjing 211816, PR China
Nanjing Tech University, 30 Puzhu Rd S., Nanjing 211816, PR China

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Pages:: 82–86

Online Publication Date:: Jun 2015

Publication Date:: 01 Jun 2015

Article Category:: Research Article

DOI:: https://doi.org/10.1556/1846.2014.00043

Keywords:: coumarin; continuous-flow approach

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Continuous-flow synthesis of coumarin was realized in a tandem microflow system containing two microreactors in this study. Generally, better reaction yield (91%) and less side reaction were obtained in the flow system compared with conventional method. Interestingly, different reaction pathways were observed between continuous-flow system and batch methods.

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Journal of Flow Chemistry A Journal of the Flow Chemistry Society

Print ISSN:: 2062-249X

Online ISSN:: 2063-0212

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Journal of Flow Chemistry
Language	English
Size	A4
Year of Foundation	2011
Volumes per Year	1
Issues per Year	4
Founder	Áramlásos Kémiai Tudományos Társaság
Founder's Address	H-1031 Budapest, Hungary Záhony utca 7.
Publisher	Akadémiai Kiadó Springer Nature Switzerland AG
Publisher's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245. CH-6330 Cham, Switzerland Gewerbestrasse 11
Responsible Publisher	Chief Executive Officer, Akadémiai Kiadó
ISSN	2062-249X (Print)
ISSN	2063-0212 (Online)