Efficient continuous-flow synthesis of macrocyclic triazoles

Anne-Catherine Bédard; Jeffrey Santandrea; Shawn K. Collins

doi:10.1556/jfc-d-14-00042

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Journal of Flow Chemistry

Volume/Issue:: Volume 5: Issue 3

Efficient continuous-flow synthesis of macrocyclic triazoles

Authors:

Anne-Catherine Bédard

Anne-Catherine Bédard Université de Montréal, CP 6128 Station Downtown, Montréal, Québec, H3C 3J7, Canada

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Jeffrey Santandrea

Jeffrey Santandrea Université de Montréal, CP 6128 Station Downtown, Montréal, Québec, H3C 3J7, Canada

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, and

Shawn K. Collins

Shawn K. Collins Université de Montréal, CP 6128 Station Downtown, Montréal, Québec, H3C 3J7, Canada

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Pages:: 142–144

Online Publication Date:: Sep 2015

Publication Date:: 01 Sep 2015

Article Category:: Rapid Communication

DOI:: https://doi.org/10.1556/jfc-d-14-00042

Keywords:: macrocycle; click; copper

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The continuous-flow synthesis of a series of 11- to 26-membered macrocycles via copper-catalyzed azide-alkyne cycloaddition is reported. The approach employs homogeneous catalysis to promote formation of triazole-containing macrocycles in good to excellent yields (65–90%) at relatively high concentration (30–50 mM) using a phase separation strategy.

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Journal of Flow Chemistry A Journal of the Flow Chemistry Society

Print ISSN:: 2062-249X

Online ISSN:: 2063-0212

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Journal of Flow Chemistry
Language	English
Size	A4
Year of Foundation	2011
Volumes per Year	1
Issues per Year	4
Founder	Áramlásos Kémiai Tudományos Társaság
Founder's Address	H-1031 Budapest, Hungary Záhony utca 7.
Publisher	Akadémiai Kiadó Springer Nature Switzerland AG
Publisher's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245. CH-6330 Cham, Switzerland Gewerbestrasse 11
Responsible Publisher	Chief Executive Officer, Akadémiai Kiadó
ISSN	2062-249X (Print)
ISSN	2063-0212 (Online)