Journal of Flow Chemistry
Volume/Issue:
Volume 5: Issue 4
Studies on the continuous-flow synthesis of nonpeptidal bis-tetrahydrofuran moiety of Darunavir
Authors:
Raquel A. C. Leão Universidade Federal do Rio de Janeiro, Rio de Janeiro, Bloco A 622, RJ 21941—909, Brazil

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Raquel de O. Lopes Universidade Federal do Rio de Janeiro, Rio de Janeiro, Bloco A 622, RJ 21941—909, Brazil

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Marco A. de M. Bezerra Universidade Federal do Rio de Janeiro, Rio de Janeiro, Bloco A 622, RJ 21941—909, Brazil

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Mauro N. Muniz Universidade Federal do Rio Grande do Sul, Faculty of Pharmacy,, Av. Ipiranga, 2752, Porto Alegre-RS, 90610—000, Brazil

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Bruna B. Casanova Universidade Federal do Rio Grande do Sul, Faculty of Pharmacy,, Av. Ipiranga, 2752, Porto Alegre-RS, 90610—000, Brazil

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Simone C. B. Gnoatto Universidade Federal do Rio Grande do Sul, Faculty of Pharmacy,, Av. Ipiranga, 2752, Porto Alegre-RS, 90610—000, Brazil

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Grace Gosmann Universidade Federal do Rio Grande do Sul, Faculty of Pharmacy,, Av. Ipiranga, 2752, Porto Alegre-RS, 90610—000, Brazil

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Laszlo Kocsis Faculty of Pharmacy, Budapest 1031, Brazil

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Rodrigo O.M.A. de Souza Universidade Federal do Rio de Janeiro, Rio de Janeiro, Bloco A 622, RJ 21941—909, Brazil

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Leandro S. de M. Miranda Universidade Federal do Rio de Janeiro, Rio de Janeiro, Bloco A 622, RJ 21941—909, Brazil

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Pages:
216–219
Online Publication Date:
Dec 2015
Publication Date:
01 Dec 2015
Article Category:
Research Article
DOI:
https://doi.org/10.1556/1846.2015.00031
Keywords:
bis-tetrahydrofuran; HIV protease; continuous flow
Restricted access

The use of continuous-flow chemistry has shown to be an important tool in improving API manufacture. In the present paper, we report the use of continuous-flow reactors in the synthesis of the bicyclic side chain of antiretroviral Darunavir.

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Cover Journal of Flow Chemistry
Journal of Flow Chemistry A Journal of the Flow Chemistry Society
Print ISSN:
2062-249X
Online ISSN:
2063-0212

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Journal of Flow Chemistry
Language English
Size A4
Year of
Foundation		 2011
Volumes
per Year		 1
Issues
per Year		 4
Founder Áramlásos Kémiai Tudományos Társaság
Founder's
Address		 H-1031 Budapest, Hungary Záhony utca 7.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 2062-249X (Print)
ISSN 2063-0212 (Online)

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