JPC - Journal of Planar Chromatography - Modern TLC
Volume/Issue:
Volume 16: Issue 5
Qualitative and quantitative analysis of diosmin in tablets by thin-layer chromatography with densitometric UV detection
Authors: Zbigniew Janeczko 1 , Urszula Hubicka 2 , Jan Krzek 2 , and Irma Podolak 1
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  • 1 Jagiellonian University Department of Pharmacognosy, Collegium Medicum Medyczna 9 30-688 Cracow Poland
  • | 2 Jagiellonian University Department of Inorganic and Analytical Chemistry, Collegium Medicum Medyczna 9 30-688 Cracow Poland
Pages:
377–380
Online Publication Date:
08 Mar 2007
Publication Date:
01 Oct 2003
Article Category:
Research Article
DOI:
https://doi.org/10.1556/jpc.16.2003.5.9
Keywords:
Diosmin; TLC densitometry; Analysis of pharmaceuticals
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Conditions have been established for determination of diosmin in pharmaceutical formulations, for example ‘Diosminin’, by TLC with densitometric detection. Chromatographic separation on silica gel was performed with chloroform-methanol-water, 23 + 12 + 2 ( v/v ), as mobile phase and the spots were analyzed by densitometry at λ = 344 nm. Under the experimental conditions established repeatable and accurate results were obtained. The method is characterized by high sensitivity — the limit of detection was 20 ng — and satisfactory recovery — from 99.8 to 103.0%. Response was linearly dependent on concentration in the range 5 to 50 μg mL −1 .

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Cover JPC - Journal of Planar Chromatography - Modern TLC
JPC - Journal of Planar Chromatography - Modern TLC
Print ISSN:
0933-4173
Online ISSN:
1789-0993

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Journal of Planar Chromatography - Modern TLC
Language English
Size A4
Year of
Foundation		 1988
Volumes
per Year		 1
Issues
per Year		 6
Founder Akadémiai Kiadó
Founder's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 0933-4173 (Print)
ISSN 1789-0993 (Online)

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