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  • 1 Jagiellonian University Department of Pharmacognosy, Collegium Medicum Medyczna 9 30-688 Cracow Poland
  • | 2 Jagiellonian University Department of Inorganic and Analytical Chemistry, Collegium Medicum Medyczna 9 30-688 Cracow Poland
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Conditions have been established for determination of diosmin in pharmaceutical formulations, for example ‘Diosminin’, by TLC with densitometric detection. Chromatographic separation on silica gel was performed with chloroform-methanol-water, 23 + 12 + 2 ( v/v ), as mobile phase and the spots were analyzed by densitometry at λ = 344 nm. Under the experimental conditions established repeatable and accurate results were obtained. The method is characterized by high sensitivity — the limit of detection was 20 ng — and satisfactory recovery — from 99.8 to 103.0%. Response was linearly dependent on concentration in the range 5 to 50 μg mL −1 .

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Journal of Planar Chromatography - Modern TLC
Language English
Size A4
Year of
Foundation
1988
Volumes
per Year
1
Issues
per Year
6
Founder Akadémiai Kiadó
Founder's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 0933-4173 (Print)
ISSN 1789-0993 (Online)

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