Bio-pharmaceutical R&D is increasingly an international affair. Research articles published in the peer-reviewed international
scientific and technical journals represent quantifiable research outputs of bio-pharmaceutical firms. Large-scale systemic
measurements of worldwide trends and sectoral patterns within bio-pharmaceutical science can be gauged from these articles,
where coauthored research papers are assumed to reflect research cooperation and associated knowledge flows and exchanges.
We focus our attention on the largest science-based multinational enterprises (MNEs), those that produce relatively large
quantities of research articles. The study deals with the worldwide output of research articles that are co-produced by corporate
researchers during the years 1996–2001.
We employ these publications to examine structural factors characterizing research cooperation networks within industry at
the level of major geographical regions (North America, Europe, Pacific-Asia), with a breakdown by within-MNE and between-MNE
network linkages. The descriptive statistics on publication output and results of network analyses of co-publication linkages
not only indicate regional differences, with a central role for US companies in biopharmaceutical research, but also a variety
of firm-specific research cooperation networks which enabled us to develop a tentative typology of MNEs in terms of their
intra- and interorganizational patterns of research cooperation linkages.