Summary
A new, specific, sensitive, selective, precise, and reproducible high-performance thin-layer chromatographic (HPTLC) method has been established for study of the stability of 3-acetyl-11-keto-β-boswellic acid (AKBA). HPTLC was performed on aluminium foil plates coated with 200 μm silica gel 60F254. Linear ascending development with toluene-ethyl acetate 7:3 (v/v) was performed at room temperature (25 ± 2°C) in a twin-trough glass chamber saturated with mobile phase vapour. Compact bands (RF 0.52 ± 0.02) were obtained for AKBA. Spectrodensitometric scanning was performed in absorbance mode at 250 nm. Linear regression analysis of the calibration plots showed there was a good linear relationship (r2 = 0.9989 ± 0.0002) between peak area and concentration in the range 200–1200 ng band−1. The method was validated for precision, recovery, robustness, specificity, and detection and quantification limits, in accordance with ICH guidelines. The limits of detection and quantification were 3.06 and 9.29 ng band−1, respectively. The recovery of the method was 99.35–100.21%. AKBA was subjected to various stress test conditions — acid and alkali hydrolysis, oxidation, photodegradation, and dry and wet heat treatment. Degradation products were well resolved from the pure drug with significantly different RF values. Statistical analysis showed the method could be successfully applied for the estimation of AKBA in herbal extract and in nanoparticles. Because the method could effectively separate the drug from its degradation products, it can be regarded as stability-indicating.
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Senior editors
Editor(s)-in-Chief: Kowalska, Teresa (1946-2023)
Editor(s)-in-Chief: Sajewicz, Mieczyslaw
Editors(s)
- Danica Agbaba (University of Belgrade, Belgrade, Serbia)
- Łukasz Komsta (Medical University of Lublin, Lublin, Poland)
- Ivana Stanimirova-Daszykowska (University of Silesia, Katowice, Poland)
- Monika Waksmundzka-Hajnos (Medical University of Lublin, Lublin, Poland)
Editorial Board
- R. Bhushan (The Indian Institute of Technology, Roorkee, India)
- J. Bojarski (Jagiellonian University, Kraków, Poland)
- B. Chankvetadze (State University of Tbilisi, Tbilisi, Georgia)
- M. Daszykowski (University of Silesia, Katowice, Poland)
- T.H. Dzido (Medical University of Lublin, Lublin, Poland)
- A. Felinger (University of Pécs, Pécs, Hungary)
- K. Glowniak (Medical University of Lublin, Lublin, Poland)
- B. Glód (Siedlce University of Natural Sciences and Humanities, Siedlce, Poland)
- A. Gumieniczek (Medical University of Lublin, Lublin, Poland)
- U. Hubicka (Jagiellonian University, Kraków, Poland)
- K. Kaczmarski (Rzeszow University of Technology, Rzeszów, Poland)
- H. Kalász (Semmelweis University, Budapest, Hungary)
- K. Karljiković Rajić (University of Belgrade, Belgrade, Serbia)
- I. Klebovich (Semmelweis University, Budapest, Hungary)
- A. Koch (Private Pharmacy, Hamburg, Germany)
- P. Kus (Univerity of Silesia, Katowice, Poland)
- D. Mangelings (Free University of Brussels, Brussels, Belgium)
- E. Mincsovics (Corvinus University of Budapest, Budapest, Hungary)
- Á. M. Móricz (Centre for Agricultural Research, Budapest, Hungary)
- G. Morlock (Giessen University, Giessen, Germany)
- A. Petruczynik (Medical University of Lublin, Lublin, Poland)
- R. Skibiński (Medical University of Lublin, Lublin, Poland)
- B. Spangenberg (Offenburg University of Applied Sciences, Germany)
- T. Tuzimski (Medical University of Lublin, Lublin, Poland)
- Y. Vander Heyden (Free University of Brussels, Brussels, Belgium)
- A. Voelkel (Poznań University of Technology, Poznań, Poland)
- B. Walczak (University of Silesia, Katowice, Poland)
- W. Wasiak (Adam Mickiewicz University, Poznań, Poland)
- I.G. Zenkevich (St. Petersburg State University, St. Petersburg, Russian Federation)
KOWALSKA, TERESA (1946-2023)
E-mail: kowalska@us.edu.pl
SAJEWICZ, MIECZYSLAW
E-mail:msajewic@us.edu.pl
Indexing and Abstracting Services:
- Science Citation Index
- Sci Search
- Research Alert
- Chemistry Citation Index and Current Content/Physical
- Chemical and Earth Sciences
- SCOPUS
- GoogleScholar
- Index Copernicus
- CABI
- CABELLS Journalytics
| 2021 | |
|---|---|
| Web of Science | |
| Total Cites WoS |
652 |
| Journal Impact Factor | 2,011 |
| Rank by Impact Factor | Chemistry, Analytical 66/87 |
| Impact Factor without Journal Self Cites |
1,789 |
| 5 Year Impact Factor |
1,350 |
| Journal Citation Indicator | 0,40 |
| Rank by Journal Citation Indicator | Chemistry, Analytical 72/99 |
| Scimago | |
| Scimago H-index |
29 |
| Scimago Journal Rank |
0,27 |
| Scimago Quartile Score | Chemistry (miscellaneous) (Q3) |
| Scopus | |
| Scopus Cite Score |
2,8 |
| Scopus CIte Score Rank |
General Chemistry 210/409 (Q3) |
| Scopus SNIP |
0,586 |
|
2020
|
|
|
Total Cites
|
650
|
|
WoS
|
|
|
Journal
Impact Factor |
1,639
|
|
Rank by
|
Chemistry, Analytical 71/83 (Q4)
|
|
Impact Factor
|
|
|
Impact Factor
|
1,412
|
|
without
|
|
|
Journal Self Cites
|
|
|
5 Year
|
1,301
|
|
Impact Factor
|
|
|
Journal
|
0,34
|
|
Citation Indicator
|
|
|
Rank by Journal
|
Chemistry, Analytical 75/93 (Q4)
|
|
Citation Indicator
|
|
|
Citable
|
45
|
|
Items
|
|
|
Total
|
43
|
|
Articles
|
|
|
Total
|
2
|
|
Reviews
|
|
|
Scimago
|
28
|
|
H-index
|
|
|
Scimago
|
0,316
|
|
Journal Rank
|
|
|
Scimago
|
Chemistry (miscellaneous) Q3
|
|
Quartile Score
|
|
|
Scopus
|
393/181=2,2
|
|
Scite Score
|
|
|
Scopus
|
General Chemistry 215/398 (Q3)
|
|
Scite Score Rank
|
|
|
Scopus
|
0,560
|
|
SNIP
|
|
|
Days from
|
58
|
|
submission
|
|
|
to acceptance
|
|
|
Days from
|
68
|
|
acceptance
|
|
|
to publication
|
|
|
Acceptance
|
51%
|
| Rate |
| 2019 | |
|---|---|
| Total Cites WoS |
495 |
| Impact Factor | 1,418 |
| Impact Factor without Journal Self Cites |
1,374 |
| 5 Year Impact Factor |
0,936 |
| Immediacy Index |
0,460 |
| Citable Items |
50 |
| Total Articles |
50 |
| Total Reviews |
0 |
| Cited Half-Life |
6,2 |
| Citing Half-Life |
8,3 |
| Eigenfactor Score |
0,00048 |
| Article Influence Score |
0,164 |
| % Articles in Citable Items |
100,00 |
| Normalized Eigenfactor |
0,05895 |
| Average IF Percentile |
20,349 |
| Scimago H-index |
26 |
| Scimago Journal Rank |
0,255 |
| Scopus Scite Score |
226/167=1,4 |
| Scopus Scite Score Rank |
Chemistry (miscellaneous) 240/398 (Q3) |
| Scopus SNIP |
0,494 |
| Acceptance Rate |
41% |
| Acta Chromatographica | |
|---|---|
| Publication Model | Online only Gold Open Access |
| Submission Fee | none |
| Article Processing Charge | 400 EUR/article |
| Regional discounts on country of the funding agency | World Bank Lower-middle-income economies: 50% World Bank Low-income economies: 100% |
| Further Discounts | Editorial Board / Advisory Board members: 50% Corresponding authors, affiliated to an EISZ member institution subscribing to the journal package of Akadémiai Kiadó: 100% |
| Subscription Information | Gold Open Access |
| Purchase per Title | |
| Acta Chromatographica | |
|---|---|
| Language | English |
| Size | A4 |
| Year of Foundation |
1988 |
| Volumes per Year |
1 |
| Issues per Year |
4 |
| Founder | Institute of Chemistry, University of Silesia |
| Founder's Address |
PL-40-007 Katowice, Poland, Bankowa 12 |
| Publisher | Akadémiai Kiadó |
| Publisher's Address |
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245. |
| Responsible Publisher |
Chief Executive Officer, Akadémiai Kiadó |
| ISSN | 2083-5736 (Online) |
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