Summary
A reliable and sensitive reversed-phase high performance liquid chromatography (RP-HPLC) with ultraviolet (UV) detection method was developed and validated for the quantification of hopantenic acid in human plasma. Hopantenic acid, with protocatechuic acid as the internal standard (IS), was extracted from plasma samples using a liquid-liquid extraction with methanol. A chromatographic separation was achieved on a Luna C18 column (4.6 mm × 150 mm, 5-μm particle size) and precolumn of the same sorbent (2.0 mm). An isocratic elution, at a flow rate of 1.0 mL min−1, was used with a mobile phase consisting of acetonitrile, water, and 0.03% trifluoroacetic acid. The UV detector was set to 205 nm. The elution times for hopantenic acid and IS were ∼4.3 and 5.4 min, respectively. The calibration curve of hopantenic acid was linear (r > 0.9994) over the range of 0.5–100 μg mL−1 in human plasma. The limit of detection and limit of quantification for hopantenic acid were 0.034 and 0.103 μg mL−1, respectively. The present method was successfully applied for the estimation of pharmacokinetic parameters of hopantenic acid following single oral administration of tablets containing 250 mg hopantenic acid to healthy volunteers. For hopantenic acid, the data showed a mean maximum plasma concentration (Cmax) of 2.32 μg mL−1, with a time to reach peak plasma concentration (tmax) of 1.56 h.
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Senior editors
Editor(s)-in-Chief: Kowalska, Teresa (1946-2023)
Editor(s)-in-Chief: Sajewicz, Mieczyslaw
Editors(s)
- Danica Agbaba (University of Belgrade, Belgrade, Serbia)
- Łukasz Komsta (Medical University of Lublin, Lublin, Poland)
- Ivana Stanimirova-Daszykowska (University of Silesia, Katowice, Poland)
- Monika Waksmundzka-Hajnos (Medical University of Lublin, Lublin, Poland)
Editorial Board
- R. Bhushan (The Indian Institute of Technology, Roorkee, India)
- J. Bojarski (Jagiellonian University, Kraków, Poland)
- B. Chankvetadze (State University of Tbilisi, Tbilisi, Georgia)
- M. Daszykowski (University of Silesia, Katowice, Poland)
- T.H. Dzido (Medical University of Lublin, Lublin, Poland)
- A. Felinger (University of Pécs, Pécs, Hungary)
- K. Glowniak (Medical University of Lublin, Lublin, Poland)
- B. Glód (Siedlce University of Natural Sciences and Humanities, Siedlce, Poland)
- A. Gumieniczek (Medical University of Lublin, Lublin, Poland)
- U. Hubicka (Jagiellonian University, Kraków, Poland)
- K. Kaczmarski (Rzeszow University of Technology, Rzeszów, Poland)
- H. Kalász (Semmelweis University, Budapest, Hungary)
- K. Karljiković Rajić (University of Belgrade, Belgrade, Serbia)
- I. Klebovich (Semmelweis University, Budapest, Hungary)
- A. Koch (Private Pharmacy, Hamburg, Germany)
- P. Kus (Univerity of Silesia, Katowice, Poland)
- D. Mangelings (Free University of Brussels, Brussels, Belgium)
- E. Mincsovics (Corvinus University of Budapest, Budapest, Hungary)
- Á. M. Móricz (Centre for Agricultural Research, Budapest, Hungary)
- G. Morlock (Giessen University, Giessen, Germany)
- A. Petruczynik (Medical University of Lublin, Lublin, Poland)
- R. Skibiński (Medical University of Lublin, Lublin, Poland)
- B. Spangenberg (Offenburg University of Applied Sciences, Germany)
- T. Tuzimski (Medical University of Lublin, Lublin, Poland)
- Y. Vander Heyden (Free University of Brussels, Brussels, Belgium)
- A. Voelkel (Poznań University of Technology, Poznań, Poland)
- B. Walczak (University of Silesia, Katowice, Poland)
- W. Wasiak (Adam Mickiewicz University, Poznań, Poland)
- I.G. Zenkevich (St. Petersburg State University, St. Petersburg, Russian Federation)
KOWALSKA, TERESA (1946-2023)
E-mail: kowalska@us.edu.pl
SAJEWICZ, MIECZYSLAW
E-mail:msajewic@us.edu.pl
Indexing and Abstracting Services:
- Science Citation Index
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- Chemistry Citation Index and Current Content/Physical
- Chemical and Earth Sciences
- SCOPUS
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- CABI
- CABELLS Journalytics
| 2021 | |
|---|---|
| Web of Science | |
| Total Cites WoS |
652 |
| Journal Impact Factor | 2,011 |
| Rank by Impact Factor | Chemistry, Analytical 66/87 |
| Impact Factor without Journal Self Cites |
1,789 |
| 5 Year Impact Factor |
1,350 |
| Journal Citation Indicator | 0,40 |
| Rank by Journal Citation Indicator | Chemistry, Analytical 72/99 |
| Scimago | |
| Scimago H-index |
29 |
| Scimago Journal Rank |
0,27 |
| Scimago Quartile Score | Chemistry (miscellaneous) (Q3) |
| Scopus | |
| Scopus Cite Score |
2,8 |
| Scopus CIte Score Rank |
General Chemistry 210/409 (Q3) |
| Scopus SNIP |
0,586 |
|
2020
|
|
|
Total Cites
|
650
|
|
WoS
|
|
|
Journal
Impact Factor |
1,639
|
|
Rank by
|
Chemistry, Analytical 71/83 (Q4)
|
|
Impact Factor
|
|
|
Impact Factor
|
1,412
|
|
without
|
|
|
Journal Self Cites
|
|
|
5 Year
|
1,301
|
|
Impact Factor
|
|
|
Journal
|
0,34
|
|
Citation Indicator
|
|
|
Rank by Journal
|
Chemistry, Analytical 75/93 (Q4)
|
|
Citation Indicator
|
|
|
Citable
|
45
|
|
Items
|
|
|
Total
|
43
|
|
Articles
|
|
|
Total
|
2
|
|
Reviews
|
|
|
Scimago
|
28
|
|
H-index
|
|
|
Scimago
|
0,316
|
|
Journal Rank
|
|
|
Scimago
|
Chemistry (miscellaneous) Q3
|
|
Quartile Score
|
|
|
Scopus
|
393/181=2,2
|
|
Scite Score
|
|
|
Scopus
|
General Chemistry 215/398 (Q3)
|
|
Scite Score Rank
|
|
|
Scopus
|
0,560
|
|
SNIP
|
|
|
Days from
|
58
|
|
submission
|
|
|
to acceptance
|
|
|
Days from
|
68
|
|
acceptance
|
|
|
to publication
|
|
|
Acceptance
|
51%
|
| Rate |
| 2019 | |
|---|---|
| Total Cites WoS |
495 |
| Impact Factor | 1,418 |
| Impact Factor without Journal Self Cites |
1,374 |
| 5 Year Impact Factor |
0,936 |
| Immediacy Index |
0,460 |
| Citable Items |
50 |
| Total Articles |
50 |
| Total Reviews |
0 |
| Cited Half-Life |
6,2 |
| Citing Half-Life |
8,3 |
| Eigenfactor Score |
0,00048 |
| Article Influence Score |
0,164 |
| % Articles in Citable Items |
100,00 |
| Normalized Eigenfactor |
0,05895 |
| Average IF Percentile |
20,349 |
| Scimago H-index |
26 |
| Scimago Journal Rank |
0,255 |
| Scopus Scite Score |
226/167=1,4 |
| Scopus Scite Score Rank |
Chemistry (miscellaneous) 240/398 (Q3) |
| Scopus SNIP |
0,494 |
| Acceptance Rate |
41% |
| Acta Chromatographica | |
|---|---|
| Publication Model | Online only Gold Open Access |
| Submission Fee | none |
| Article Processing Charge | 400 EUR/article |
| Regional discounts on country of the funding agency | World Bank Lower-middle-income economies: 50% World Bank Low-income economies: 100% |
| Further Discounts | Editorial Board / Advisory Board members: 50% Corresponding authors, affiliated to an EISZ member institution subscribing to the journal package of Akadémiai Kiadó: 100% |
| Subscription Information | Gold Open Access |
| Purchase per Title | |
| Acta Chromatographica | |
|---|---|
| Language | English |
| Size | A4 |
| Year of Foundation |
1988 |
| Volumes per Year |
1 |
| Issues per Year |
4 |
| Founder | Institute of Chemistry, University of Silesia |
| Founder's Address |
PL-40-007 Katowice, Poland, Bankowa 12 |
| Publisher | Akadémiai Kiadó |
| Publisher's Address |
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245. |
| Responsible Publisher |
Chief Executive Officer, Akadémiai Kiadó |
| ISSN | 2083-5736 (Online) |
Monthly Content Usage
| Abstract Views | Full Text Views | PDF Downloads | |
|---|---|---|---|
| Dec 2022 | 0 | 7 | 4 |
| Jan 2023 | 0 | 10 | 5 |
| Feb 2023 | 0 | 7 | 8 |
| Mar 2023 | 0 | 2 | 1 |
| Apr 2023 | 0 | 1 | 3 |
| May 2023 | 0 | 2 | 4 |
| Jun 2023 | 0 | 3 | 3 |
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