Authors:
Robert GreenUniversity of Southampton Chemistry Southampton SO17 1 BJ UK

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Richard BrownUniversity of Southampton Chemistry Southampton SO17 1 BJ UK

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Derek PletcherUniversity of Southampton Chemistry Southampton SO17 1 BJ UK

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In order for microflow electrolysis cells to make their full contribution to routine laboratory organic synthesis, they must be capable of carrying out reactions with good selectivity and high conversion at a high rate of conversion. In addition to appropriate choice of the electrolysis medium and control of the overall cell chemistry, both the design of the electrolysis cell (including materials of construction) and the correct selection of the cell current and flow rate of the solution are critical in determining performance. The conclusions are tested using the methoxylation of N-formylpyrrolidine as the test reaction in a microflow electrolysis cell with a single, long, patterned flow channel.

  • (a) Watts, P.; Haswell, S. J. Chem. Soc. Rev.2005, 34, 235â€"246; (b) Mason, B. P.; Price, K. E.; Steinbacher, J. L.; Bogdan, A. R.; McQuade, D. T. Chem. Rev. 2007, 107, 2300â€"2318; (c) Fukuyama, T.; Rahman, T.; Sato M.; Ryu, I. Synlett2008, 151â€"163; (d) Yoshida, J. Flash Chemistry: Fast Organic Synthesis in Microsystems; Wiley-VCH: Weinheim, 2008; (e) Chemical Reactions and Processes under Flow Conditions; Luis S. V.; Garcia-Verdugo, E., Eds.; Royal Society of Chemistry: Cambridge, UK, 2009; (f) Microreactors in Organic Synthesis and Catalysis, edition 2; Wirth, T., Ed; Wiley-VCH: Weinheim, 2013; (g) Microreactors in Preparative Chemistry; Reschetilowski, W., Ed.; Wiley-VCH: Weinheim, 2013; (h) Watts, K.; Baker A.; Wirth, T. J. Flow Chem.2014, 4, 2â€"11.

  • (a) Yoshida, J. Chem. Commun.2005, 4509â€"4516; (b) Horii, D.; Atobe, M.; Fuchigami T.; Marken, F. J. Electrochem. Soc.2006, 156, D143â€"D147; (c) Saito, K.; Ueoka, K.; Matsumoto, K.; Suga, S.; Nokami T.; Yoshida, J. Angew. Chem., Int. Ed.2011, 50, 5153â€"5156; (d) Attour, A.; Dirrenberger, P.; Rode, S.; Ziogas, A.; Matlosz M.; Lapique, F. Chem. Eng. Sci.2011, 66, 480â€"489; (e) Kupper, M., Hessel, V.; Lowe, H.; Stark, W.; Kinkel, J.; Michel, M.; Schmidt-Traub, H. Electrochim. Acta.2003, 48, 2889â€"2896; (f) Simms, R.; Dubinsky, S.; Yudin, A.; Kumasheva, E. Lab. Chip.2009, 9, 2395â€"2397; (g) Ziogas, A.; Kolb, G.; O'Connell, M.; Attour, A.; Lapicque, F.; Matlosz M.; Rode, S. J. Appl. Electrochem.2009, 39, 2297â€"2313; (h) Bouzek, K.; JiÅ(tm)ičnÃ1/2, V.; KodÃ1/2m, R.; KÅ(tm)išťál, J.; Bystroň, T. Electrochim. Acta.2010, 55, 8172â€"8181; (i) Kashiwagi, T.; Amemiya, F.; Fuchigami, T.; Atobe, M.; Chem. Commun.2012, 48, 2806â€"2808; (j) Kuleshova, J.; Hill-Cousins, J. T.; Birkin, P. R.; Brown, R. C. D.; Pletcher, D.; Underwood, T. J. Electrochim. Acta. 2011, 56, 4322â€"4326.

  • Kuleshova, J.; Hill-Cousins, J. T.; Birkin, P. R.; Brown, R. C. D.; Pletcher, D.; Underwood, T. J. Electrochim. Acta. 2012, 69, 197â€"202.

  • Roth, G. P.; Stalder, R.; Long, T. R.; Sauer D. R.; Djuric. S. W. J. Flow Chem. 2013, 3, 34â€"40.

  • Stalder, R.; Roth, G. P. Med. Chem. Lett. 2013, 4, 1119â€"1123.

  • Steckhan, E.; Arns, T.; Heineman, W. R.; Hilt, G.; Hoormann, D.; Jörissen, J.; Kröner, L.; Lewall, B.; PÃ1/4tter. H. Chemosphere2001, 43, 63â€"73.

  • Paddon, C. A.; Atobe, M.; Fuchigami, T.; He, P.; Watts, P.; Haswell, S. J.; Pritchard, G. T.; Bull S. D.; Marken, F. J. Appl. Electrochem. 2006, 36, 617â€"634.

  • (a) Bard A. J.; Faulkner, L. R. Electrochemical Methods â€" Fundamentals and Applications; John Wiley & Sons: New York, 2001; (b) Walsh, F. C. A First Course in Electrochemical Engineering; The Electrochemistry Consultancy, 1993; (c) Pletcher D.; Walsh, F. C. Industrial Electrochemistry, edition 2; Chapman and Hall: London, 1990.

  • Scialdone, O.; Guarisco, C.; Galia, A. Electrochim. Acta2011, 58, 463â€"373.

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Journal of Flow Chemistry
Language English
Size A4
Year of
Foundation
2011
Volumes
per Year
1
Issues
per Year
4
Founder Áramlásos Kémiai Tudományos Társaság
Founder's
Address
H-1031 Budapest, Hungary Záhony utca 7.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 2062-249X (Print)
ISSN 2063-0212 (Online)