Authors:
Tamás FődiBudapest University of Technology and Economics, PO Box 91, H-1521 Budapest, Hungary

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József KupaiBudapest University of Technology and Economics, PO Box 91, H-1521 Budapest, Hungary

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György TúrósChemical Works of Gedeon Richter Plc., PO Box 27, H-1475 Budapest, Hungary

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Tamás NémethBudapest University of Technology and Economics, PO Box 91, H-1521 Budapest, Hungary

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Eszter RojikBudapest University of Technology and Economics, PO Box 91, H-1521 Budapest, Hungary

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Eszter RiethmüllerChemical Works of Gedeon Richter Plc., PO Box 27, H-1475 Budapest, Hungary

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György Tibor BaloghBudapest University of Technology and Economics, PO Box 91, H-1521 Budapest, Hungary
Chemical Works of Gedeon Richter Plc., PO Box 27, H-1475 Budapest, Hungary

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Péter HuszthyBudapest University of Technology and Economics, PO Box 91, H-1521 Budapest, Hungary

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This paper reports a new continuous-flow synthesis of chiral and achiral pyridino-18-crown-6 ethers. Macrocyclizations have been performed in a packed-bed flow reactor where deprotonation of a bifunctional primary or a secondary alcohol takes place with potassium hydroxide as a heterogeneous base avoiding the use of stronger and more dangerous one, sodium hydride. Ditosylate derivatives of pyridine as precursors for the macrocyclization used in batch condition were replaced by the appropriate diiodides and optimization of the parameters provided higher yields in shorter reaction times. The setup presented here is suitable for the preparation of different ethers by Williamsontype syntheses in continuous-flow reactions.

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Journal of Flow Chemistry
Language English
Size A4
Year of
Foundation
2011
Volumes
per Year
1
Issues
per Year
4
Founder Áramlásos Kémiai Tudományos Társaság
Founder's
Address
H-1031 Budapest, Hungary Záhony utca 7.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 2062-249X (Print)
ISSN 2063-0212 (Online)

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