A Raynaud-jelenséget az ujjak hideg, illetve pszichés stressz hatására kialakuló vasospasmusa jellemzi, amely az ujjak bőrszínének jellegzetes elszíneződéséhez vezet. A jelenség hátterében a vasoconstrictor és vasodilatator faktorok egyensúlyának megbomlása áll. Megkülönböztetünk primer, illetve a különböző alapbetegségekhez, köztük autoimmun kórállapotokhoz társuló szekunder formát. A diagnózis fizikális, kapillármikroszkópos, képalkotó és immunológiai vizsgálatok alapján állítható fel. A kezelés során alapvető feltétel a hideghatás, az érzelmi stresszhelyzetek és bizonyos gyógyszerek elkerülése. Roham esetén különféle vasodilatatorok, prosztaglandinanalógok, illetve antikoagulánsok lehetnek hatékonyak. Az összefoglaló közleményben a szerzők részletesen áttekintik a betegség jellemzőit, továbbá az elérhető diagnosztikai és terápiás lehetőségeket. Orv. Hetil., 2012, 153, 403–409.
Heidrich, H.: Functional vascular diseases: Raynaud’s syndrome, acrocyanosis and erythromelalgia. Vasa, 2010, 39, 33–41.
Heidrich H. , 'Functional vascular diseases: Raynaud’s syndrome, acrocyanosis and erythromelalgia ' (2010 ) 39 Vasa : 33 -41 .
Lambova, S. N., Müller-Ladner, U.: The role of capillaroscopy in differentiation of primary and secondary Raynaud’s phenomenon in rheumatic diseases: a review of the literature and two case reports. Rheumatol. Int., 2009, 29, 1263–1271.
Müller-Ladner U. , 'The role of capillaroscopy in differentiation of primary and secondary Raynaud’s phenomenon in rheumatic diseases: a review of the literature and two case reports ' (2009 ) 29 Rheumatol. Int. : 1263 -1271 .
Herrick, A. L., van den Hoogen, F., Gabrielli, A., et al.: Modified-release sildenafil reduces Raynaud’s phenomenon attack frequency in limited cutaneous systemic sclerosis. Arthritis Rheum., 2011, 63, 775–782.
Gabrielli A. , 'Modified-release sildenafil reduces Raynaud’s phenomenon attack frequency in limited cutaneous systemic sclerosis ' (2011 ) 63 Arthritis Rheum. : 775 -782 .
Rosato, E., Molinaro, I., Pisarri, S., et al.: Digital ulcers as an initial manifestation of systemic lupus erythematosus. Intern. Med., 2011, 50, 767–769.
Pisarri S. , 'Digital ulcers as an initial manifestation of systemic lupus erythematosus ' (2011 ) 50 Intern. Med. : 767 -769 .
Hartmann, P., Mohokum, M., Schlattmann, P.: The association of Raynaud’s syndrome with carpal tunnel syndrome: a meta-analysis. Rheumatol. Int., 2011. Sep. 7. [Epub ahead of print.]
Bovenzi, M.: A longitudinal study of vibration white finger, cold response of digital arteries, and measures of daily vibration exposure. Int. Arch. Occup. Environ. Health, 2010, 83, 259–272.
Bovenzi M. , 'A longitudinal study of vibration white finger, cold response of digital arteries, and measures of daily vibration exposure ' (2010 ) 83 Int. Arch. Occup. Environ. Health : 259 -272 .
Purdie, G. L., Purdie, D. J., Harrison, A. A.: Raynaud’s phenomenon in medical laboratory workers who work with solvents. J. Rheumatol., 2011, 38, 1940–1946.
Harrison A. A. , 'Raynaud’s phenomenon in medical laboratory workers who work with solvents ' (2011 ) 38 J. Rheumatol. : 1940 -1946 .
Cutolo, M., Pizzorni, C., Secchi, M. E., et al.: Capillaroscopy. Best. Pract. Res. Clin. Rheumatol., 2008, 22, 1093–1108.
Secchi M. E. , 'Capillaroscopy ' (2008 ) 22 Best. Pract. Res. Clin. Rheumatol. : 1093 -1108 .
Ngian, G. S., Sahhar, J., Wicks, I. P., et al.: Cardiovascular disease in systemic sclerosis – an emerging association? Arthritis Res. Ther., 2011, 13, 237.
Wicks I. P. , 'Cardiovascular disease in systemic sclerosis – an emerging association? ' (2011 ) 13 Arthritis Res. Ther. : 237 -.
Herrick, A. L.: Pathogenesis of Raynaud’s phenomenon. Rheumatology (Oxford), 2005, 44, 587–596.
Herrick A. L. , 'Pathogenesis of Raynaud’s phenomenon ' (2005 ) 44 Rheumatology (Oxford) : 587 -596 .
Chatterjee, S.: Management of Raynaud’s phenomenon in the patient with connective tissue disease. Curr. Treat. Options Cardiovasc. Med., 2010, 12, 185–204.
Chatterjee S. , 'Management of Raynaud’s phenomenon in the patient with connective tissue disease ' (2010 ) 12 Curr. Treat. Options Cardiovasc. Med. : 185 -204 .
Rosato, E., Molinaro, I., Rossi, C., et al.: The combination of laser Doppler perfusion imaging and photoplethysmography is useful in the characterization of scleroderma and primary Raynaud’s phenomenon. Scand. J. Rheumatol., 2011, 40, 292–298.
Rossi C. , 'The combination of laser Doppler perfusion imaging and photoplethysmography is useful in the characterization of scleroderma and primary Raynaud’s phenomenon ' (2011 ) 40 Scand. J. Rheumatol. : 292 -298 .
Salem, K. M., Baker, M., Hilliam, R. M., et al.: Analysis of rewarming curves in Raynaud’s phenomenon of various aetiologies. J. Hand Surg. Eur., 2009, 34, 621–626.
Hilliam R. M. , 'Analysis of rewarming curves in Raynaud’s phenomenon of various aetiologies ' (2009 ) 34 J. Hand Surg. Eur. : 621 -626 .
Bovenzi, M.: Finger systolic blood pressure indices for the diagnosis of vibration-induced white finger. Int. Arch. Occup. Environ. Health, 2002, 75, 20–28.
Bovenzi M. , 'Finger systolic blood pressure indices for the diagnosis of vibration-induced white finger ' (2002 ) 75 Int. Arch. Occup. Environ. Health : 20 -28 .
Lambova, S. N., Müller-Ladner, U.: The specificity of capillaroscopic pattern in connective autoimmune diseases. A comparison with microvascular changes in diseases of social importance: arterial hypertension and diabetes mellitus. Mod. Rheumatol., 2009, 19, 600–605.
Müller-Ladner U. , 'The specificity of capillaroscopic pattern in connective autoimmune diseases. A comparison with microvascular changes in diseases of social importance: arterial hypertension and diabetes mellitus ' (2009 ) 19 Mod. Rheumatol. : 600 -605 .
Kim, Y. H., Ng, S. W., Seo, H. S., et al.: Classification of Raynaud’s disease based on angiographic features. J. Plast. Reconstr. Aesthet. Surg., 2011, 64, 1503–1511.
Seo H. S. , 'Classification of Raynaud’s disease based on angiographic features ' (2011 ) 64 J. Plast. Reconstr. Aesthet. Surg. : 1503 -1511 .
Csiki, Z., Garai, I., Varga, J., et al.: Microcirculation of the fingers in Raynaud’s syndrome 99mTc-DTPA imaging. Nuklearmedizin, 2005, 44, 29–32.
Varga J. , 'Microcirculation of the fingers in Raynaud’s syndrome 99mTc-DTPA imaging ' (2005 ) 44 Nuklearmedizin : 29 -32 .
Csiki, Z., Garai, I., Shemirani, A. H., et al.: The effect of metoprolol alone and combined metoprolol-felodipin on the digital microcirculation of patients with primary Raynaud’s syndrome. Microvasc. Res., 2011, 82, 84–87.
Shemirani A. H. , 'The effect of metoprolol alone and combined metoprolol-felodipin on the digital microcirculation of patients with primary Raynaud’s syndrome ' (2011 ) 82 Microvasc. Res. : 84 -87 .
García-Carrasco, M., Jiménez-Hernández, M., Escárcega, R. O., et al.: Treatment of Raynaud’s phenomenon. Autoimmun. Rev., 2008, 8, 62–68.
Escárcega R. O. , 'Treatment of Raynaud’s phenomenon ' (2008 ) 8 Autoimmun. Rev. : 62 -68 .
Bakst, R., Merola, J. E., Franks, A. G. Jr., et al.: Raynaud’s phenomenon: pathogenesis and management. J. Am. Acad. Dermatol., 2008, 59, 633–653.
Franks A. G. , 'Raynaud’s phenomenon: pathogenesis and management ' (2008 ) 59 J. Am. Acad. Dermatol. : 633 -653 .
Schiopu, E., Hsu, V. M., Impens, A. J., et al.: Randomized placebo-controlled crossover trial of tadalafil in Raynaud’s phenomenon secondary to systemic sclerosis. J. Rheumatol., 2009, 36, 2264–2268.
Impens A. J. , 'Randomized placebo-controlled crossover trial of tadalafil in Raynaud’s phenomenon secondary to systemic sclerosis ' (2009 ) 36 J. Rheumatol. : 2264 -2268 .
Levien, T. L.: Advances in the treatment of Raynaud’s phenomenon. Vasc. Health Risk. Manag., 2010, 6, 167–177.
Levien T. L. , 'Advances in the treatment of Raynaud’s phenomenon ' (2010 ) 6 Vasc. Health Risk. Manag. : 167 -177 .
Herrick, A. L.: Contemporary management of Raynaud’s phenomenon and digital ischaemic complications. Curr. Opin. Rheumatol., 2011, 23, 555–561.
Herrick A. L. , 'Contemporary management of Raynaud’s phenomenon and digital ischaemic complications ' (2011 ) 23 Curr. Opin. Rheumatol. : 555 -561 .
Khan, M. I., Tariq, M., Rehman, A., et al.: Efficacy of cervicothoracic sympathectomy versus conservative management in patients suffering from incapacitating Raynaud’s syndrome after frost bite. J. Ayub Med. Coll. Abbottabad, 2008, 20, 21–24.
Rehman A. , 'Efficacy of cervicothoracic sympathectomy versus conservative management in patients suffering from incapacitating Raynaud’s syndrome after frost bite ' (2008 ) 20 J. Ayub Med. Coll. Abbottabad : 21 -24 .