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  • 1 Semmelweis University Szentkirályi u. 46 H-1088 Budapest Hungary
  • | 2 Péterfy Hospital Budapest Hungary
  • | 3 National Institute for Food Safety and Nutrition Budapest Hungary
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Research justified that natural antioxidants and bioactive agents related to antioxidant effects could act on signal transduction pathways and/or phase II enzyme activities directly and/or indirectly. These molecules can also influence the apoptotic genes. In the case of plant extracts, which contain several active compounds, one might consider it is impossible to discover the single mechanism of action. This problem becomes even more complicated, when we bring the obtained data of in vitro and in vivo experiments into consideration. Therefore the multifactorial actions must be analyzed in long-term in vivo studies on redox homeostasis. The questions are: can the absorbed compounds of natural extracts from the gastrointestinal tract influence the changed cellular redox states and how can these molecules act on the redox homeostasis of blood in IBD patients? Our aim was to present the protective effect of a natural product made from Raphanus sativus niger squeezed juice (0.2 g/die Raphacol bile granule) in a twelve-month clinical study in patients suffering from IBD. Raphacol treatment did not influence the activity of IBD. Beside beneficial subjective judgement, bile acid level was elevated continuously and the values of redox parameters were decreased in the plasma during treatment. The granule diminished the erythrocyte chemiluminescence significantly and the HbA 1c -level moderately until the beginning of the ninth month. After this, the trend has changed until the end. Data showed that antioxidant and isothiocyanate-rich granule could influence the redox homeostasis of IBD patients even at low dose.

Hungarian Medical Journal
Language English
Size  
Year of
Foundation
2007
Publication
Programme
ceased
Volumes
per Year
 
Issues
per Year
 
Publisher Akadémiai Kiadó
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 1788-6139 (Print)
ISSN 1789-0403 (Online)

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